GREEN SYNTHESIS AND EVALUATION OF BIOLOGICAL IMPACT OF Zn(II), Cd(II) AND Hg(II) COMPLEXES WITH PHENYLACETYLUREA AND BUTANOATE ION LIGANDS

Authors

  • A. ARUNACHALAM PG & Research Department of Chemistry, Bishop Heber College (Autonomous), Tiruchirappalli 620017
  • T. Ramachandramoorthy PG & Research Department of Chemistry, Bishop Heber College (Autonomous), Tiruchirappalli 620017
  • S. Padmavathy PG & Research Department of Chemistry, Bishop Heber College (Autonomous), Tiruchirappalli 620017
  • S. Amala Fathima Rani Department of Chemistry, Holy Cross College (Autonomous), Tiruchirappalli 620002, India.

Keywords:

Zn(II), Cd(II) and Hg(II) complexes, Phenylacetyl urea, Antibacterial, Anti fungal

Abstract

Objective: To prepare Zn(II), Cd(II) and Hg(II) complexes containing Phenylacetyl urea (PAU), and butanoate (but) ligands and to characterize physic-chemical, spectral and biological properties.

Methods: All the three metal complexes were prepared by the addition of required mole ratios of phenylacetylurea in methanol and sodium butanoate in ethanol to the methanolic metal nitrate solutions followed by microwave irradiation for ~10 seconds after each addition of ligands. The precipitated complexes were filtered, washed with ethanol and dried. The molecular formulae and probable geometry of the complexes were arrived at from the estimation of metals, electrical conductivities and electronic spectral data. The antimicrobial and anti fungal screening of the complexes against the bacteria, viz., Staphylococcus sp, Escherichia coli, Shigella flexneri, Raoultella planticola, Pseudomonas aeruginosa and fungi, viz., Candida albicans, Aspergillus oryzae, Aspergillus niger, Aspergillus flavus and Aspergillus sojae were carried out by well diffusion method. Antioxidantal activities were carried out by diphenylpicrylhydrazyl (DPPH) free radical scavenging method.

Results: The molecular formulae of the three complexes were arrived as [Zn(PAU)(but)2], [Cd(PAU)(but)2] and [Hg(PAU)(but)2]. The antibacterial and anti fungal activities (diameter inhibition) of the complexes were in the range of 25-36 mm at 100 µg/ml concentration and 11-30 mm at 400 µg/ml concentration respectively. The percentage inhibition of DPPH free radical scavenging of Zn(II), Cd(II) and Hg(II) complexes were 44.13, 36.25 and 24.68 respectively.

Conclusion: The results indicate that all the three complexes are biologically active and the biological activities are higher than pure PAU and but ligands.

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References

Shazia Rafique, Muhammad Idrees, Anwar Nasim, Haji Akbar and Amin Athar. Transition metal complexes as potential therapeutic agents. J Biotechnology and Molecular Biology Reviews 2010;5(2):38-45.

Jenny P Glusker, Amy K Katz and Charles W Bock. Metal ions in Biological Systems. The Rigaku J 1999;16(2):8-17.

Rosette M, Roat-Malone. Bioinorganic Chemistry-A short Course. 2nd ed. John Wiley & Sons Inc. New Jersey;2007. p.1-6.

Yogesh P Patil, Sachin H Pawar, Sharu Jadhav, and Jitendra S Kadu. Biochemistry of metal absorption in Human Body: Reference to check Impact of Nano Particles on Human Being. Int J of Scientific and Res Publications 2013;3(4):1-5.

Walaa H Mahmoud, Gegad G Mahamed, Maher M I El-dessouky. Synthesis, Characterization and in vitro Biological Activity of Mixed Transition Metal Complexes of Lornoxicam with 1,10-phenanthroline. Int J Electrochem Sci 2014;9:1415-38.

Warra A A. Transition metal complexes and their application in drugs and cosmetics – A Review. J Chem Pharm Res 2011;3(4):951-8.

Joshua A Obaleye, Adedibu C Tella and Mercy O Bamigboye. Metal Complexes as Prospective Antibacterial Agents. A Search for Antibacterial Agents. Varaprasad Bobbarala editor. InTech Janeza Trdine;2012. p.197-218.

Drug Bank: Phenacemide (DB01121). www. drugbank. ca/ drugs/DB01121.‎

Ravichandran S, Karthikeyan E.Microwave Synthesis-A Potential Tool for Green Chemistry. Int J of Chem Tech Res 2011;3:466-70.

Neha Yadav, Bhojak N. Microwave Assisted Synthesis Spectral and Antibacterial Investigations on Co (II) Complexes with Amide Ligands. Int J of Engineering and Sci 2013;2(2):166-8.

Oxana V Kharissova, Boris I Kharisov and Ubaldo Ortiz Méndez. Advances in Induction and Microwave Heating of Mineral and Organic Materials. InTech Europe;2011. p.346-7.

Gunasekaran P. Laboratory manual in Microbiology. New Age International Pub;2000. p.75-77.

Omar B. Ibrahim, Mahmoud A. Mohamed and Moamen S. Refat. Nano Sized Schiff Base Complexes with Cd(II), Co(II), Cu(II), Ni(II) and Zn(II) Metals. Synthesis, Spectroscopic and Medicinal Studies. J Canadian Chemical Transactions 2014;2(2):108-21.

Kaan Kucukoglu, Hayrunnisa Nadaroglu. Assessment of the antioxidant and antiradicalic capacities in vitro of different phenolic derivatives. J Free Radicals and Antioxidants 2014;4(1):24-31.

Mendham J, Denney R.C, Dbarners J, Thomas M and Shivsankar B. Vogels’ Text Book of Quantitative Chemical Analysis. 6th ed. J Longman Scientific & Technical;2009. p.329.

Akrawi BA and Ali AMJ. The Electrical Conductivity of Some Transition Metal Complexes with 2,2`-Bipyridyl in Different Solvents at 298.16K. National J of Chemistry 2008;(31):491-500.

John Coates. In:R.A. Meyers editor. Interpretation of Infrared Spectra, A Practical Approach in Encyclopedia of Analytical Chemistry. J Ó John Wiley and Sons Ltd Chichester;2000. p.10815-37.

Paulina L Páez, Claudia M Bazán, María E Bongiovanni, Judith Toneatto, Inés Albesa, María C Becerra, and Gerardo A. Argüello. Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli. J Bio Med Res Int 2013;1-7.

Dominika Hagel, Agata Paneth, Tomasz Pleach:Synthesis, Characterization and Antimicrobial Activity of 4-Benzoyl-1-(pyrazin-2-ylcarbonyl)-thiosemicarbazide. J of Single Molecule Res 2014;2(10):6-13.

Butu M, Rodino S, Butu A, Butnariu M:Screening of Bioflavonoid and Antioxidantal Activity of Lens Culinaris Medikus. Digest J of Nanomaterials and Biostructures 2014;9(2):519-29.

Published

31-08-2014

How to Cite

ARUNACHALAM, A., T. Ramachandramoorthy, S. Padmavathy, and S. A. Fathima Rani. “GREEN SYNTHESIS AND EVALUATION OF BIOLOGICAL IMPACT OF Zn(II), Cd(II) AND Hg(II) COMPLEXES WITH PHENYLACETYLUREA AND BUTANOATE ION LIGANDS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 91-94, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/1285.

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