PHARMACOLOGICAL EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC POTENTIAL OF LITCHI CHINENSIS GAERTN.(SONN.)
Keywords:
Litchi chinensis Gaertn leaves, Anti-inflammatory, Analgesic activityAbstract
Objective: Litchi chinensis Gaertn. is a tropical fruit tree used traditionally for several ailments including inflammatory and painful disorders. This study was designed to investigate the potential of hydroalcohol extract of Litchi chinensis Gaertn. leaves (HLCL) for anti-inflammatory and analgesic activity in laboratory animals.
Methods: Hydro-alcoholic extract of leaves were sequentially prepared by Soxhlet apparatus and subjected to preliminary phytochemical screening. The anti-inflammatory activity was evaluated by employing carrageenan induced paw edema in rats and analgesic activity was evaluated using acetic acid induced writhing test and hot plate method in mice.
Results: The preliminary phytochemical analysis of extracts indicated the presence of terpenoids, flavonoids, phenols, tannins, saponins. Oral administration of 100, 200 and 400 mg/kg of HLCL exhibited a significant anti-inflammatory activity and maximum effect was observed after 4 hour of carrageenan administration. The percentage inhibition of glacial acetic acid induced writhing was found to be 11%, 26.3%, 45% at 100, 200 and 400 mg/kg dose respectively. Similar results were observed in hot plate model indicating the analgesic activity.
Conclusion: The results showed that HA extract of Litchi chinensis Gaertn. produced significant anti-inflammatory and analgesic activity in rats and mice respectively.
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