HYPOGLYCEMIC ACTIVITY OF COPERNICIACERIFERA MART.L.EAF POWDER EXTRACT IN THE TREATMENT OF ALLOXAN-INDUCED DIABETIC MICE

Authors

  • Paula Alves Salmito Rodrigues Laboratory of Human Biochemistry of the State University of Ceará (1700 Silas Munguba Avenue, Block D, Itaperi Campus, 60740-000)
  • Izabel Florindo Guedes Laboratory of Human Biochemistry of the State University of Ceará (1700 Silas Munguba Avenue, Block D, Itaperi Campus, 60740-000)
  • MARCIA MARIA MENDES MARQUES Laboratory of Human Biochemistry of the State University of Ceará (1700 Silas Munguba Avenue, Block D, Itaperi Campus, 60740-000)
  • Isaac Neto Goes Da Silva Laboratory of Veterinary Clinical Pathology of the State University of Ceará (1700 Silas Munguba Avenue, Itaperi Campus, 60740-000)
  • ICARO GUSMAO PINTO VIEIRA Laboratory of Natural Products (1700 Silas Munguba Avenue, Itaperi Campus, 60740-000)

Keywords:

Carnauba wax, Cinnamic acid esters, Diabetes Mellitus

Abstract

Objective: This study characterizeesters from carnauba crude powder and evaluates its hypoglycemic effect on the treatment of diabetic animals.

Methods: Groups of diabetic micewere induced by alloxan and treated with carnauba crude powder. Blood samples were collected to determine the glucose serum level.

Results: The compound was identified and characterized as diester of the 4-methoxycinnamic acid (PCO-C) and presented hypoglycemic effect in the concentrations of 100 and 150 mg/kgbody weight (b.w. )The concentration 150 mg/kg b.w..o.f PCO-C presented the best effect on controlling glucose levels (p<0.05),when compared to the reference drug.

Conclusion: The results indicate that the PCO-C is a promising therapeutic compound with hypoglycemic effect. This action can be justified by the presence of the diester of 4- methoxycinnamic acid.

Downloads

Download data is not yet available.

References

Shrivastava RBL, Shrivastava PS, Ramasamy J. Role of self-care in management of diabetes mellitus. J Diabetes Metabolic Disorders 2013;12(14):1-5.

Tabish SA. Is diabetes becoming the biggest epidemic of the twenty-first century? Int J Health Sci 2007;1(2):5-8.

Wild S, Roglic G, Green A. Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27(5):1047-53.

Harley E, Mirsky N, Ofir R. Antidiabeticatributes of desert and steppicplantts: a review. Planta Med 2013;79(6):425-36.

OkpuzorJ, Adebesin O, Ogbunugafor H, Amadi I. The potential of medicinal plants in sickle cell disease control: a review. Int J Biom Health Sci 2008;4(2):47-55.

Leila Z, Eliandra DS, Luisa HC, Anildo CJ. Effect of crude extract and fractions from Vitexmegapotamica leaves on hyperglycemia in alloxan diabetic rats. J Ethnopharmacol 2007;109(1):151-55.

Katiyar D, Singh B, Lall AM, Haldar C. Efï¬cacy of chitooligosaccharides for the management of diabetes in alloxan induced mice: a correlative study with antihyperlipidemic and antioxidative activity. Eur J Pharm Sci 2011;44(4):534-43.

Negri G. Diabetes melito: plantas e princípios ativos naturais hipoglicemiantes. Rev Bras Ciênc Farm 2005;41(2):121-42.

Dang KH, Singh Z, Swinny EE. Edible coatings Influence fruit ripening, Quality, and aroma biosynthesis in mango fruit. J Agric Food Chem 2008;56(4):1361-70.

Arias MA, Loxley A, Eatmon C, Roey GV, Fairhurst D, Mitchnick M, et al. Carnauba wax nanoparticles enhance strong systemic and mucosal cellular and humoral immune responses to HIV-gp140 antigen. Vaccine 2011;29(6):1258-69.

Barman K, Asrey R, Pal RK. Putrescine and carnauba wax pretreatments alleviate chilling injury, enhance shelf life and preserve pomegranate fruit quality during cold storage. Sci Hortic 2011;130:795-800.

Jo WS, Song HY, Song NB, Lee JH, Min SC, Song KB. Quality and microbial safety of ‘Fuji’ apples coated with carnauba-shellac wax containing lemongrass oil. LWT-Food Sci Technol 2014;55(2):490-97.

Ullmann F, Gerhartz W, Yamamoto YS, Campbell FT, Pfefferkorn R, Rounsaville JF. Ullmann´s Encyclopedia of Industrial Chemistry. Frankfurt, Germany: VCH-Verlagsgesellschaft;1996.

Hwanga KT, Cuppett SL, Wellerc LC, Hannad AM. HPLC of grain sorghumwax classes highlighting separation of aldehydes fromwax esters and steryl esters. J Sep Sci 2002;25(9):619-23.

Weitzel G, Fretzdorff AM, Stock W. Syntheses and hypoglycemic activities of ethyl esters and various amides of omega-guanidino fatty acids with medium chain length. H Oppe Seylers Z Physiol Chem 1980;361(1):41-50.

Malaisse W, Lebrun P. Mechanisms of sulfonylurea-lnduced insulin release. Diabetes Care 1990;13(3):9-17.

Vandenburg LE, Wilder EA. Aromatic acids of carnauba wax. J Am Oil Chem Soc 1967;44(11):659-62.

Vandenburg LE, Wilder EA. The structural constituents of carnauba wax. J Am Oil Chem Soc 1970;47(12):514-18.

Organization for Economic Cooperation and Development (OECD) guidelines for acute toxicity of chemicals. No. 425 (Adopted: 3 October 2008).

Jain DK, Arya RK. Anomalies in alloxan-induced diabetic model: it is better to standardize it first. Indian J Pharmacol 2011;43(1):91.

Misra M, Aiman U. Alloxan: an unpredictable drug for diabetes induction? Indian J Pharmacol 2012;44(4):538-39.

Pareek H, Sharma S, Khajja BS, Jain K, Jain GC. Evaluation of hypoglycemic and anti-hyperglycemic potential of Tridaxprocumbens (Linn.). BMC Complement Altern Med 2009;9(48):1-7.

Kim JS, Godber JS, King J, Priyawiwatkul W. Inhibition of cholesterol autoxidation by the nonsaponifiable fraction in rice bran in an aqueous model system. J Am Oil Chem Soc 2001;78(7):685-9.

Fang N, Yu S, Badger TM. Characterization of triterpene alcohol and sterol ferulates in rice bran using LC-MS/MS. J Agric Food Chem 2003;51(11):3260-67.

Berthold HK, Unverdorben S, Degenhardt R, Bulitta M, Gouni-Berthold I. Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: a randomized controlled trial. Jama 2006;295(19):2262-9.

Castaño G, Mas R, Fernandéz R, Ilinait J, Gámez R, Alvarez E. Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind study. Int J Clin Pharmacol Res 2001;21(1):43-57.

Son MJ, Rico CW, Nam SH, Kang MY. Effect of oryzanol and ferulic acid on the glucose metabolism of mice fed with a high-fat diet. J Food Sci 2011;76(1):7-10.

Justo ML, Rodriguez-Rodriguez R, Claro CM, Alvarez de Sotomayor M, Parrado J, Herrera MD. Water-soluble rice bran enzymatic extract attenuates dyslipidemia, hypertension and insulin resistance in obese Zucker rats. Eur J Nutr 2013;52(2):789-97.

Spiazzi CC, Manfredini V, Barcellos da Silva FE, Flores EM, Izaguirry AP, Vargas LM, Soares MB, Santos FW. γ-Oryzanol protects against acute cadmium-induced oxidative damage in mice testes. Food Chem Toxicol 2013;55:526-32.

Marongiu B, Piras A, Porcedda S. Comparative analysis of the oil and supercritical CO2 extract of Elettariacardamomum (L.) Maton. J Agric Food Chem 2004;52(20):6278-82.

Published

01-10-2014

How to Cite

Rodrigues, P. A. S., I. F. Guedes, M. M. MENDES MARQUES, I. N. G. D. Silva, and I. G. PINTO VIEIRA. “HYPOGLYCEMIC ACTIVITY OF COPERNICIACERIFERA MART.L.EAF POWDER EXTRACT IN THE TREATMENT OF ALLOXAN-INDUCED DIABETIC MICE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 10, Oct. 2014, pp. 115-8, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/2256.

Issue

Section

Original Article(s)

Most read articles by the same author(s)