ANTI-INFLAMMATION EFFECTS OF BIOACTIVE FRACTION DLBS0533 CONTAINING PHALERIA MACROCARPA AND NIGELLA SATIVA ON ANIMAL MODEL

Authors

  • Raymond R. Tjandrawinata Dexa Laboratories of Biomolecular Sciences (DLBS)
  • Ipang Djunarko Faculty of Pharmacy, Sanata Dharma University, Jogjakarta, Indonesia
  • Fenty Faculty of Pharmacy, Sanata Dharma University, Jogjakarta, Indonesia
  • Phebe Hendra Faculty of Pharmacy, Sanata Dharma University, Jogjakarta, Indonesia

Keywords:

DLBS0533, Anti-inflammation, Mice, Edema, Carragenan

Abstract

Objective:  DLBS0533 extract is a bioactive fraction obtained from combination of Phaleria macrocarpa and Nigella sativa. This present study aims to observe its potentially anti-inflammatory activities using carragenaan-induced paw edema in mice as animal model.

Methods:  Mice were divided into control, positive control and dose groups. Diclofenac potassium was used as a positive control. Treatment DLBS0533 was given at dose 39, 78 and 156 mg/kg body weight (b. w.). Edema thickness was examined for 6 hours.

Results:  Reduction in edema is shown in 27.26%; 30.71% and 32.72% at dose of 39, 78 and 156 mg/kg b. w., respectively. Comparation between dose groups and positive control group show that dose 156 mg/kg b. w. did not give significantly different. Therefore, dose 39 and 78 mg/kg b. w. also gave anti-inflammatory activities proved by reduction in edema.

Conclusions:  Taken together, DLBS0533 potentially have anti-inflammatory activities.

 

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Published

01-01-2015

How to Cite

Tjandrawinata, R. R., I. Djunarko, Fenty, and P. Hendra. “ANTI-INFLAMMATION EFFECTS OF BIOACTIVE FRACTION DLBS0533 CONTAINING PHALERIA MACROCARPA AND NIGELLA SATIVA ON ANIMAL MODEL”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 1, Jan. 2015, pp. 408-11, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/2471.

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