THE EMERGENCE OF TIME PROGRAMMED DRUG DELIVERY SYSTEM: CHRONOTHERAPY OF CARDIO VASCULAR DISEASES
Keywords:
Pulsatile drug delivery system, Chronotherapy, Cardiovascular diseases, Pulsatile technologyAbstract
Time programmed drug delivery system is a system that promises to deliver a drug at a point of time when it is most required, as it is programmed beforehand. Though the delivery system is a boon to the pharmaceutical research due to its desired release profile feature and application to numerous disease areas like hypercholesterolemia, asthma, cardiovascular disease, peptic and duodenal ulcers and cancers of various categories, its special significance is due to its potential applications in chronotherapeutic drug delivery, where the pinnacle aim of devising this drug delivery system is to obtain a programmed release at desired time points, with a lag time where no drug is released. Lot of work is being carried out lately, to understand the relationship between the rhythmicity in disease symptoms and the biological clock, but a special mention is required in case of diseases associated with cardiovascular functions. Cardiovascular system works on a frequency cycle and it resonates hour to hour with the biological clock except in cases of disturbances from any external stimuli, which leads to CVSdisorders. Correcting the rhythmicity of the frequency cycles of heart, which are apparently in sync with the master clock, can be done or achieved by delivering the drug exactly at the point of time when it is needed the most. This will minimize the side effects and maximize the benefits of the administered dose. This review focuses on the importance of circadian rhythm and chronotherapy in the management of CVSand overall physiology, scientific evidences of their relationship, role and importance of PDDS in formulation management and finally the work done in this direction and the marketed chronotheraptics delivery systems available for CVS disorders.
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