POTENTIAL CYTOTOXIC DRUG EFFECTS OF SECONDARY METABOLITES DERIVED FROM SELECTED MEDICINAL PLANTS OF SAVANADURGA FOREST IN KARNATAKA

Authors

  • Ashwatha Reddy Ravikumar Dept. of P. G. Studies & Research in Biotechnology & Bioinformatics, Kuvempu University, Shankaraghatta 577451, Karnataka, India. Nitya Genome Technologies Pvt. Ltd., Bangalore 560003, Karnataka, India
  • Varun Madgaonkar Dept of Biotechnology, PES Institute of Technology, Bangalore 560085, Karnataka, India
  • R. T. VENKATESHA Department of Biotechnology, Dayananda Sagar College of Biological Sciences, Bangalore 560078, Karnataka, India
  • BHARATHI R. Department of Computer Science Engineering, BMS Institute of Technology, Bangalore 560064
  • V. Krishna Murthy Dept of Biotechnology, PES Institute of Technology, Bangalore 560085, Karnataka, India

Keywords:

Brine Shrimp Lethality Assay, Potato Crown Gall Tumor Inhibition Assay, Kirganelia reticulata, Camptothecin, Catharanthus roseus, Withania somnifera, cytotoxicity

Abstract

Objective: To evaluate the potential cytotoxic and antitumor activities of secondary metabolites of selected medicinal plants of Savanadurga forest, Karnataka.

Methods: The soxhlet extracted crude methanolic leaf extracts of nineteen medicinal plants were assessed for their potential cytotoxic and antitumor activities by brine shrimp lethality assay and potato tumor inhibition assay at 100μg/ml respectively.

Results: Kirganelia reticulata and Cissus quadrangularis showed highest cytotoxicity while Flacourtia indica failed to show any inhibitory activity in brine shrimp lethality assay. Kirganelia reticulata exhibited 100% antitumor activity while Albizzia amara failed to show any antitumor activity as tested by crown gall tumor inhibition assay.

Conclusion: Both brine shrimp lethality assay and potato tumor inhibition assay indicated that Kirganelia reticulata seems to be the best anticancer plant.

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Published

01-10-2014

How to Cite

Ravikumar, A. R., V. Madgaonkar, R. T. VENKATESHA, B. R., and V. K. Murthy. “POTENTIAL CYTOTOXIC DRUG EFFECTS OF SECONDARY METABOLITES DERIVED FROM SELECTED MEDICINAL PLANTS OF SAVANADURGA FOREST IN KARNATAKA”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 10, Oct. 2014, pp. 238-41, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/2607.

Issue

Vol 6, Issue 10, 2014

Section

Original Article(s)