CURCUMIN ATTENUATES LEAD (Pb)–INDUCED NEUROBEHAVIORL AND NEUROBIOCHEMICAL DYSFUNCTION: A REVIEW
DOI:
https://doi.org/10.22159/ijpps.2018v10i8.27191Keywords:
Lead neurotoxity, Curcumin, Neurobehavior, AntioxidantAbstract
Lead is one of the common chemical elements that is assigned the symbol Pb which came from the Latin Plumbum. Pb is widely used in the field of coating, refine and glaze ceramics and pottery. It is still used in the production of products like water pipes, cooking utensils and cooking utensils. In addition it is also used in insulation of building ceilings, cable coverage and military industries. Lead enter the environment from those uses and from the environment it enter into the living organisms. Lead accumulates in many humanorgans, but the brain is the target organ of lead accumulation. Neurotoxicity of lead is, one of lead toxicity, caused many symptoms. There are many behavioral and biochemical modifications induced by lead toxicity like learning and memory deficits, anxiety disorders, social and sexual behavior modifications and neurotransmitter system deficits. Curcumin is a bioactive natural phytochemical phenolic compound (diferuloylmethane) extracted from the rhizome of Curcuma longa. Most studies indicated the role of curcumin in reducing the damage of lead toxicity. In the current review, emphasis was based on the toxicity of lead and its effect on behavior and some neurotransmitters related to behavior. The effect of curcumin is improving the neurotoxicity and behavioral toxicity of lead.
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Abu-Taweel G, Ajarem JS. Effect of perinatal lead exposure on the social behaviour of laboratory mice o ffspring at adolescent age. S J Biol Sci 2008;15:67-72.
Saad TM. Effect of curcumin on some heavy metals induced renal and testicular injuries in male rats. Egypt J Hosp Med 2013;53:770-81.
Jaishankar M, Tseten T, Anbalagan N, Blessy B. Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol 2014;7:60–72.
Wani AL, Ara A, Usmani JA. Lead toxicity: a review. Interdiscip Toxicol 2015;8:55–64.
Ahamed M, Siddiqui MKJ. Environmental lead toxicity and nutritional factors. Clin Nut 2007;26:400–8.
Ajarem J. Effect of prenatal lead exposure on motoric Reflexes of developing mice preweanlings and their locomotory behavior at adolescent age. J Egy German Soc Zool 1999;30:163-76.
Trebucobich MS, Hazelhoff MH, Chevalier AA. Protein expression of kidney and liver bilitranslocase in rats exposed to mercuric chloride—a potential tissular biomarker of toxicity. Toxicol Lett 2014;225:305–10.
Laamech J, El-Hilaly J, Fetoui H, Chtourou Y, Tahraoui A, Lyoussi B. Nephroprotective effects of Berberis vulgaris L. total extract on lead acetate-induced toxicity in mice. Int J Pharm Pharm Sci 2016;78:326-33.
Assi MA, Hezmee MNM, Haron AW, Sabri MYM, Rajion MAli. The detrimental effects of lead on human and animal health. Vet World 2016;9:660–71.
Geetha KA, Alummoottil NJ. Preparation and characterization of curcumin loaded cassava starch nanoparticles with improved cellular absorption. Int J Pharm Pharm Sci 2014;6:171-6.
Hiimani J, Uma B, Bibhu PP. TO assess the potential of curcumin against gut microbiota-induced alteration in choline metabolism in c57bl/6j mice. Int J Pharm Pharm Sci 2017;9:215-26.
Betharia S, Maher TJ. Neurobehavioral effects of lead and manganese individually and in combination in developmentally exposed rats. Neurotoxicology 2012;33:1117-27.
Ciftci O, Aydin M, Ozdemir I, Vardi N. Quercetin prevents 2, 3, 7, 8â€tetrachlorodibenzoâ€pâ€dioxinâ€induced testicular damage in rats. Andrologia 2012;3:164-73.
Cleveland LM, Minter ML, Cobb KA, Scott AA, German VF. Lead hazards for pregnant women and children: part 1: immigrants and the poor shoulder most of the burden of lead exposure in this country. Part 1 of a twoâ€part article details how exposure happens, whomit affects, and the harm it can do. AJN Am J Nurs 2008;108:40-9.
Devi C, Reddy G, Prasanthi R, Chetty C, Reddy G. Developmental lead exposure alters mitochondrial monoamine oxidase and synaptosomal catecholamine levels in rat brain. Int J Dev Neurosci 2005;23:375-81.
Donald J, Cutler M, Moore M. Effects of lead in the laboratory mouse. Development and social behaviour after lifelong exposure to 12 μM lead in drinking fluid. Neuropharmacology 1987;26:391-9.
Shawky SM, Ramadan SG, Orabi SH. Hemato-biochemical, Behavioral and Neurological effects of Vitamin C administration against lead exposure in mice. Int J 2014;2:418-29.
Shen B, Wang W, Ding L. Nuclear factor erythroid 2-related factor 2 rescues the oxidative stress induced by di-N-butylphthalate in testicular Leydig cells. Hum Exp Toxicol 2015;34:145–52.
Finkelstein Y, Markowitz ME, Rosen JF. Low-level lead-induced neurotoxicity in children: an update on central nervous system effects. Brain Res Rev 1998;27:168-76.
Flora G, Gupta D, Tiwari A. Toxicity of lead: a review with recent updates. Interdis Toxi 2012;5:47-58.
Flora SJS. Nutritional components modify metal absorption, toxic response and chelation therapy. J Nut Environ Med 2002;12:53–67.
Ashafaq M, Tabassum H, Vishnoi S, Salman M, Raisuddin S, Parvez S. Tannic acid alleviates lead acetate-induced neurochemical perturbations in rat brain. Neurosci Lett 2016;617:94-100.
Flora SJS. Arsenic induced oxidative stress and its reversibility. Free Radical Biol Med 2011;51:257–81.
Liu CM, Zheng GH, Ming QL, Sun JM, Cheng C. Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase. Environ Toxi Pharma 2013;35:502-10.
Garcia MTA, Gonzalez ELM. Toxic eff ects of perinatal lead exposure on the brain of rats: Involvement of oxidative stress and the benefi cial role of antioxidants. Food Chem Toxicol 2008;46:2089–95.
Ghoniem MH, El-Sharkawy NI, Hussein MM, Moustafa GG. Efficacy of curcumin on lead induced nephrotoxicity in female albino rats. J Am Sci 2012;8:502-10.
Gupta VK, Singh S, Agrawal A, Siddiqi NJ, Sharma B. Phytochemicals mediated remediation of neurotoxicity induced by heavy metals. Biochem Res Int 2015;534769:9.
Graham DL, Grace CE, Braun AA, Schaefer TL, Skelton MR, Tang PH, et al. Effects of developmental stress and lead (Pb) on corticosterone after chronic and acutestress, brain monoamines, and blood Pb levels in rats. Int J Dev Neurosci 2011;29:45-55.
Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, et al. Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int 2014. http://dx.doi.org/10.1155/2014/761264
Guidotti TL, Ragain L. Protecting children from toxic exposure: three strategies. Pediatr Clin North Am 2007;54:227–35.
Gurer H, Ercal N. Can antioxidants be beneficial in the treatment of lead poisoning? Free Radical Biol Med 2000;29:927–45.
Altintas O, Ozgen AM, Kumas M, Asil T. Neuroprotective effect of ischemic preconditioning via modulating the expression of cerebral miRNAs against transient cerebral ischemia in diabetic rats. Neurol Res 2016;38:1003.
Abu Taweel, GM Ajarem, JS Ahmad M. Protective effect of curcumin on anxiety, learning behavior, neuromuscular activities, brain neurotransmitters and oxidative stress enzymes in cadmium intoxicated mice. J Beh Brain Sci 2013;3:74.
Lidsky TI, Schneider JS. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 2003;126:5-19.
Zhai Q, Narbad A, Chen W. Dietary strategies for the treatment of cadmium and lead toxicity. Nutrients 2015;7:552-71.
Youdim KA, Spencer JP, Schroeter H, Rice-Evans C. Dietary flavonoids as potential neuroprotectants. Biol Chem 2002;383:503–19.
Willcox JK, Ash SL, Catignani GL. Antioxidants and prevention of chronic disease. Crit Rev Food Sci Nutr 2004;44:275–95.
Weston HI, Weston DD, Allen JL, Cory-Slechta DA. Sex-dependent impacts of low-level lead exposure and prenatal stress on impulsive choice behavior and associated biochemical and neurochemical manifestations. Neurotoxicology 2014;44:183.
Vaya J, Aviram M. Nutritional antioxidants mechanisms of action, analyses of activities and medical applications. Curr Med Chem Immunol Endo Metabo Agent 2000;1:99–117.
Vallone D, Picetti R, Borrelli E. Structure and function of dopamine receptors. Neurosci Biobehavioral Rev 2000;24:125-32.
Terao J. Dietary fl avonoids as antioxidants. Forum Nutr 2009;61:87–94.
Saleh HA, El-Aziz GA, El-Fark MM, El-Gohary M. Effect of maternal lead exposure on craniofacial ossification in rat fetuses and the role of antioxidant therapy. Anal Histol Embryol 2009;38:392–9.
Soeiro AC, Gouvea TS, Moreira EG. Behavioral effects induced by subchronic exposure to Pb and their reversion are concentration and gender dependent. Human Exp Toxi 2007;26:733-9.
Sanders T, Liu Y, Buchner V, Tchounwou PB. Neurotoxic effects and biomarkers of lead exposure: a review. Rev Eniron Health 2009;24:15-46.
Rastogi SK. Renal effects of environmental and occupational lead exposure. Indian J Occup Environ Med 2008;12:103–6.
Pietta PG. Flavonoids as antioxidants. J Nat Prod 2000;63:1035–42.
Phyu MP, Tangpong J. Neuroprotective effects of xanthone derivative of Garcinia mangostana against lead-induced acetylcholinesterase dysfunction and cognitive impairment. Food Chem Toxicol 2014;70:151-6.
Pearce J. Burton’s line in lead poisoning. Eur Neur 2007;57:118-9.
Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci 2006;78:2081-7.
Perez Arriaga L, Mendoza Magana M, Cortes Zarate R, Corona Rivera A, Bobadi la Morales L, Troyo-Sanromán R, et al. Cytotoxic effect of curcumin on Giardia lamblia trophozoites. Acta Tropica 2006;98:152-61.
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