ANTIHYPERLIPIDEMIC EFFECT OF ETHANOLIC SEED EXTRACT OF CANAVALIA ENSIFORMIS (L) IN HIGH FAT DIET-STREPTOZOTOCIN INDUCED RATS

Abstract

Objective: It was investigated to enlighten the phytochemical screening and antihyperlipidemic activity of seeds of Canavalia ensiformis (L.) in High fat diet Streptozotocin-induced diabetic rats.

Methods: The ethanolic seed extract of Canavalia ensiformis (EECE) at a dose of 400 mg/kg and 200 mg/kg was administered to diabetic rats. Simvastatin (4 mg/kg) is used as a standard drug.

Results: The statistics were assessed by using one way ANOVA followed by Dunnet’s multiple comparison tests. To unfold the mechanism we studied all the biochemical parameters like Total cholesterol (TC), Triglycerides (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL) and histopathological examination of Liver tissue section. The ethanolic extracts of seeds of Canavalia ensiformis showed significant reduce of the level of cholesterol, triglycerides, LDL, VLDL and a significant increase in the serum level of HDL at 400 mg/kg rather than 200 mg/kg.

Conclusion: Further the characterization and isolation of the constituents could be done to know the exact mechanism of hyperlipidemic activity. Statistical analysis of this screening method conforms that the proposed method is appropriate and it can be useful, gives the basic idea to the researcher who is working in an area like Antihyperlipidemic activity.