THE CONTRIBUTION OF CHOLINERGIC NEUROCIRCUITS OVER THE MODULATION OF DOPAMINE ACTIVITY IN THE STRIATUM
Keywords:
Dopaminergic system, Mesopontine cholinergic system, Striatum, Cholinergic interneuronsAbstract
The dopaminergic neurons and cholinergic interneurons of the striatum play key roles in motivational and sensorimotor processing by the basal ganglia. The striatal dopaminergic transmission in the forebrain is modulated by the excitatory cholinergic projections from the pedunculopontine and the laterodorsal tegmental nuclei of the hind brain by activating nicotinic and muscarinic acetylcholine receptors within the substantia nigra and ventral tegmental area. Furthermore, acetylcholine-containing interneurons in the striatum also constitute an important neural substrate for modulating dopamine activity. The striatal muscarinic acetylcholine receptors, by inhibiting acetylcholine release from cholinergic interneurons and thus modifying nicotinic acetylcholine receptor activity, offer variable control of dopamine release probability. In addition, it appears that the striatal influence of dopamine and acetylcholine cannot be fully appreciated without an understanding of their reciprocal interactions. Impairments or abnormality in these reciprocating interactions is often manifested in the form of various neuropsychiatric disorders and require extensive research to establish the optimized drug therapy. Hence the present review will serve as an aid to study the anatomical and physiological aspects of dopamine modulation as influenced by acetylcholine in striatum.
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