EFFECTS OF METFORMIN AND GLIBENCLAIMIDE COMBINATION IN IRAQI OBESE PATIENTS WITH METABOLIC SYNDROME
Keywords:
Type 2 DM, Obesity, Inflammation, Interleukin-6 (IL-6)Abstract
Objective: The prevalence of diabetes mellitus and obesity was increased world-wide as well as in Iraq. Inflammation plays important role in pathogenesis of obesity and type 2 DM. The aim of this study was to investigate the serum levels of the inflammatory markers, insulin resistance, and BMI and lipid profile in obese type 2 diabetic Iraqi patients treated with metformin and glibenclamide.
Methods: This cross sectional study was conducted at Baquba Teaching Hospital, Diyala, Iraq; from January - April 2014. Fasting blood of glucose and insuline levels, lipid profile (S. cholesterol, S. triglyceride, and S. HDL), S. Interleukin 6 (IL-6) and C-reactive protein were determined in 30 subjects; 15 healthy control and 15 diabetic obese patients.
Results: There was statistically significant difference in BMI, fasting blood sugar, insulin resistance and lipid profile between obese diabetic and control group; inflammatory markers were also significantly elevated in diabetic obese patients compared to healthy control.
Conclusion: There is augmented inflammatory response in Iraqi diabetic obese patients which plays role in higher insuÂlin resistance in these patients. Levels of inflammatory markers are increased and related to BMI and dyslipidemia in these patients.
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