SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDY OF SOME NOVEL FLUORINE BASED 2-AMINOTHIAZOLES
Keywords:
Fluorine, 2-Aminothiazoles, Hypervalent iodine, Nil, Anti-microbialAbstract
Objectives: To synthesize, characterize and evaluate antimicrobial properties of some novel fluorine based 2-aminothiazoles.
Methods: The syntheses of some novel fluorine based 2-aminothiazoles have been described by using hypervalent iodine [I(III)] mediated approach. It was observed that this is the more general and promising method for the synthesis of any thiazole, but, when other methods work, the hypervalent iodine [I(III)] mediated approach generally gives better yields. The structures of these compounds have been characterized from the rigorous analysis of their IR, 1H NMR, MS and elemental analysis. These compounds were screened for their anti-microbial activity.
Results: The results revealed that compounds 7d, 7f, 10a, 10b, 10c, 14e and 14f showed moderate to good antibacterial activity as compared with the standard drug Chloramphenicol.
Conclusion: The two thiazole synthetic methods described herein use readily available reagents and both of them are easily feasible, the hypervalent iodine mediated approach for the synthesis of title compounds is more significant because, in spite of the better yields, it avoids the use of highly toxic and lachrymatory α-halogenoketone, thereby being more eco-friendlier.
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