ANTI-INFLAMMATORY ACTIVITY OF HMG CO A REDUCTASE INHIBITORS: A COMPARATIVE STUDY

Authors

  • Rajitha Panonnummal Professor of pharmacology, College of pharmaceutical sciences, Govt Medical College, Trivandrum, Kearala.
  • Joyamma Varkey Professor of pharmacology, College of pharmaceutical sciences, Govt Medical College, Trivandrum, Kearala.

Keywords:

Atorvastatin, Rosuvastatin, Membrane stabilizing, Anti-inflammatory

Abstract

Objective: The purpose of the present study was to reveal the potential pleotropic anti-inflammatory activity of two hmg-co Reductase inhibitors, Rosuvastatin and atorvastatin in comparison with standard drug diclofenac.

Methods: The method used for screening anti-inflammatry activity was In vitro human red blood cell membrane stabilization method.

Results: The results of our study revealed that atorvastatin and rosuvastatin showed effective in vitro(500mcg/ml) anti-inflammatory activity when compared with the standard drug diclofenac.

Conclusion: The rosuvastatin was more potent anti-inflamatory drug when compared with atorvastatin.

 

Downloads

Download data is not yet available.

References

Rajendran Vadivu, KS Lakshmi. In vitro and in vivo anti-inflammatory activity of leaves of symplocos cochinchnensis (Lour) Moore ssp laurina. J Pharmacol 2008;3:121-4.

NS Parmar, Shiv Prakash. Screening methods in pharmacology: Evaluation of analgesics, anti-inflammtory and antipyretic activity. Narosa Publishing House; 2006. p. 211-39.

MR Bhurat, HS Sapakale, KG Salunkhe, RS Sanghavi, PS Kawatikwar. Preliminary chemical evaluation and in vitro anti-Inflammatory activity of leaves of Remusatia Vivipara. AJBPR 2011;2:2231-60.

Gavin J Blake, Paul M Ridker. Are statins anti-inflammatory? Curr Controlled Trials Cardiovasc Med 2000;1:161–5.

Scott S Zamvil, Lawrence Steinma. Cholesterol-lowering statins possess anti-inflammatory activity that might be useful for treatment of MI. Neurol 2002;59:970–71.

Robert Kleemann. Evidence for anti-inflammatory activity of statins and PPARa activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro. Blood J 2012;103(11):4188-94.

Todorka Savic, Boris Dindic, Vladmila Bojanic, Ruzica Jankovic, Goran Damnjanovic. Anti-inflammatory effect of statins therapy in patients with coronary disease and diabetes mellitus type 2. Med Biol 2005;13:140–5.

V Tnden, G Bano, S Gupta Aarihar. Pleiotropic effects of statins. IJP 2005;7:277-85.

Wahid A Mulla, Suyog D More, Suraj B Jamge, Ajinkya M Pawar, Mukhtar S Kazi, Madhukar R Varde. Evaluation of antiinflammatory and analgesic activities of ethanolic extract of roots Adhatoda vasica Linn. Int J Pharm Tech Res 2010;2:1364-8.

Arun Shirwaikar, Sarala Devi, EN Siju. Anti-Inflammatory activity of Thespesia populnea fruits by membrane stabilization. Int J Pharm Tech Res 2011;4:2060-3.

G Prakash Yoganandam, K Ilango, Sucharita De. Evaluation of Anti-inflammatory and membrane stabilizing properties of various extracts of Punica granatum L (Lythraceae). Int J Pharm Tech Res 2010;2:1260-3.

Armita Banani, Nasrin Maleki-Dizaji, Alireza Garjani, Hamid Soraya, Sara Mostafalou, Mojtaba Ziaee. Clavulanic acid exhibits anti-inflammatory effects on carrageenan-induced paw edema model of inflammation in rats. Ann Biol Res 2012;3:3312-20.

R Paramaguru1, K Jagadeeshwar1, CB Mahendra kumar, N Armstrong Vinod Raj. Evaluation of anti-inflammatory activity on the leaves of Filicium decipiens in experimental animal models. J Chem Pharm Res 2011;3:243-7.

M Binny K, Sunil Kumar G, Dennis Thomas. Anti-inflammatory and antipyretic properties of the rhizome of Costus speciosus (koen). JBCP 2010;14:156-7.

AC Ranar, K Nemam, L Kori, CS Sharma. Anti-inflammatory and analgesic activity of hydro-alcoholic leaves extract of Euphorbia neriifolia linn. AJPCR 2009;14:160-4.

Published

01-03-2015

How to Cite

Panonnummal, R., and J. Varkey. “ANTI-INFLAMMATORY ACTIVITY OF HMG CO A REDUCTASE INHIBITORS: A COMPARATIVE STUDY”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 3, Mar. 2015, pp. 468-9, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/3020.

Issue

Section

Short Communication(s)