ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM

Saruchi Sharma; VANEET KUMAR

doi:10.22159/ijpps.2019v11i4.31043

Authors

Saruchi Sharma Department of Biotechnology, CT Group of Institutions, Shahpur Campus, Punjab, India
VANEET KUMAR Department of Applied Sciences, CT Group of Institutions, Shahpur Campus, Punjab, India

DOI:

https://doi.org/10.22159/ijpps.2019v11i4.31043

Keywords:

Interpenetrating polymer network (IPN), drug delivery, methylmethacrylate and pantoprazole sodium

Abstract

Objective: This study involves the synthesis of Gum tragacanth (gt) based interpenetrating polymer network (ipn) and its utilization for sustained release of anti-ulcerative drug i.e. pantoprazole sodium.

Methods: IPN was synthesized from Gum tragacanth, polyacrylic acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in distilled water. Further, acryamide (aam) and methylmethacrylate (mma) was added and then kept for overnight. Later on, lipase and glutaraldehyde were added. Homopolymers and the unreacted monomers were removed using acetone. Synthesized IPN was dried at 50 °C for further study.

Synthesized ipn was swelled in water and the drug was added to it. The drug was entrapped in the pores of the synthesized ipn and then drug release behavior was studied using uv-vis spectrophotometer.

Results: Gt, paa and mma based crosslinked IPN were synthesized using lipase-glutaraldehyde as initiator-crosslinker system. The synthesized IPN was pH sensitive and possessed the desired swelling capacity required for the controlled and systematic liberation of pantoprazole sodium at 37 °C. The kinetic of drug release was studied and found that lateral diffusion (D_L) of drug was higher as compared to the initial diffusion (D_I). The prepared IPN can be used as prospective carrier for prolonged drug delivery.

Conclusion: A novel pH sensitive and colon targeted IPN was synthesized. It acts as an effective device for the controlled release of drug pantoprazole sodium.

Downloads

Download data is not yet available.

Author Biography

Saruchi Sharma, Department of Biotechnology, CT Group of Institutions, Shahpur Campus, Punjab, India

Associate Professor, Department of Biotechnology

References

Pawar SK, Pawar PS, Patel VA. Microbial polysaccharides in colon specific drug delivery. Int J Pharma Sci Rev Res 2011;6:188-96.

Kumar SNA, Pavanveena C, Kavitha K. Colonic drug delivery system of trimethazidine hydrochloride for angina pectoris. Int J Pharm Pharm Sci 2011;3:22-6.

Wang W, Wang A. Synthesis and swelling properties of pH-sensitive semi-IPN superabsorbent hydrogels based on sodium alginate-g-poly (sodium acrylate) and polyvinylpyrrolidone. Carbohydrate Polymers 2010;80:1028–36.

Hua SB, Wang AQ. Synthesis, characterization and swelling behaviors of sodium alginate-g-poly (acrylic acid)/sodium humate superabsorbent. Carbohydrate Polymers 2009;75:79–84.

Jin SP, Liu MZ, Zhang F, Chen SL, Niu AZ. Synthesis and characterization of pH-sensitivity semi-IPN hydrogel based on hydrogen bond between poly (N-vinylpyrrolidone) and poly (acrylic acid). Polymer 2006;47:1526–32.

Kabiri K, Omidian H, Hashemi SA, Zohuriaan-Mehr MJ. Synthesis of fast-swelling superabsorbent hydrogels: effect of crosslinker type and concentration on porosity and absorption rate. Eur Polymer J 2003;39:1341–8.

Wang W, Wang Q, Wang A. pH-responsive carboxymethylcellulose-g-poly(sodium acrylate)/polyvinylpyrrolidone semi-IPN hydrogels with enhanced responsive and swelling properties. Macromol Res 2011;19:57-65.

Gupta P, Vermani K, Garg S. Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discovery Today 2002;7:569-79.

Hennink WE, Nostrum CFV. Novel crosslinking method to design hydrogels. Adv Drug Delivery Rev 2002;54:13-26.

Gils PS, Ray D, Mohanta GP, Manavalan R, Sahoo P. Designing of new acrylic based macroporous superabsorbent polymer hydrogel and suitability for drug delivery. Int J Pharm Pharm Sci 2009;1:43-54.

Hekmat A, Barati EV, Frahani A, Afraj S. Synthesis and analysis of swelling and controlled release behavior of anionics IPN acrylamide based hydrogels. World Academy Sci Eng Technol 2009;56:96-100.

Wang W, Wang A. Preparation, swelling and water-retention properties of crosslinked superabsorbent hydrogel based on guar gum. Adv Mater Res 2010;96:177-82.

Peppas NA, Bures P, Lepbandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 2000;50:27-46.

Lin CC, Metters AT. Hydrogels in controlled release formulations; Network design and mathematical modeling. Adv Drug Delivery Rev 2006;58:1379-408.

Kowshik K, Vishal GN, Gowda DV, Praveen S. Formulation of immediate release (IR) atorvastatin calcium pellets and sustained release (SR) glibenclamide for fixed-dose combination dosage form. Asian J Pharma Clin Res 2018;11:159-65.

Insan SK, Iyan S, Nasrul W, Dasty LF, Rahadianti UP. Application and characterization of in situ gel. Int J Appl Pharm 2018;10:34-7.

Ruchi SS, Gowda DV, Vishal GN, Praveen S, Manjunath M. Formulation development and evaluation of almond gum based sustained release matrix tablet of indomethacin. Asian J Pharma Clin Res 2018;11:166-9.

Anas TA, Ali KA. Formulation and in vitro evaluation of amlodipine gastroretentive floating tablets using a combination of hydrophilic and hydrophobic polymers. Int J Appl Pharm 2018;10:119-25.

Tamar T, Yachin C, Joseph K. Characterization of glucose-sensitive insulin release systems in simulated in vivo conditions. Biomaterials 2000;21:1679-87.

Saruchi, Kaith BS, Jindal R, Kapur GS, Kumar V. Synthesis, characterization and evaluation of gum tragacanth and acrylic acid hydrogel for sustained calcium chloride release-enhancement of water holding capacity of soil. J Chin Adv Materials Soc 2014;2:40-52.

Anderson DMW, Weiping W. The tree exudates gum permitted in foodstuffs as emulsifiers, stabilizers and thickeners. Biol Agric Horticulture 1985;2:329-34.

Saruchi, Kaith BS, Jindal R, Kumar V. Adsorption of crude oil from aqueous solution using gum tragacanth polyacrylic acid based hydrogel. Pet Sci Technol 2015;33:278-86.

Prashar D, Kaith BS, Kalia S, Sharma S. Synthesis, characterization and evaluation of electrical stimulus sensitive behavior of Gt-cl-poly (AA) superabsorbent hydrogel. Int J Pharm Pharm Sci 2012;4:419-23.

Weiping W, Branwell A, Essex CL. Tragacanth and karaya, Woodhead Publishing Limited and CRC Press LLC; 2000.

Saruchi, Kaith BS, Jindal R, Kapoor GS. Enzyme-based green approach for the synthesis of gum tragacanth and arylic acid crosslinked superabsorbent-its utilization in controlled fertilizer release and enhancement of water holding capacity of soil. Iranian Polymer J 2013;22:561-70.

Kaith BS, Saruchi, Rajeev J, Bhatti MS. Screening and RSM optimization for synthesis of a gum tragacanth–acrylic acid based device for in situ controlled cetirizine dihydrochloride release. Soft Matter 2012;8:2286-93.

Saruchi, Kaith BS, Jindal R, Kumar V, Bhatti MS. Optimal response surface design of Gum tragacanth based poly[(acrylic acid)-co-acrylamide] IPN hydrogel for controlled release of antihypertensive drug losartan potassium. RSC Adv 2014;4:39822–9.

Khare AR, Peppas NA. Release behaviour of bioactive agents from pH-sensitive hydrogels. J Biomater Sci Polym Ed 1993;4:275-89.

Saruchi, Kaith BS, Kumar V, Jindal R. Biodegradation study of enzymatically synthesized interpenetrating polymer network: evaluation of agrochemical release and impact on soil fertility. Biotechnol Reports 2016;9:74-81.

Mohamadnia Z, Zohuriaan Mehr MJ, Kabiri K, Razavi Nouri M. Tragacanth gum-graft-polyacrylonitrile: synthesis, characterization and hydrolysis. J Polym Res 2008;15:73-180.

Saruchi, Kaith BS, Jindal R, Kumar V. Biodegradation of gum tragacanth acrylic acid based hydrogel and its impact on soil fertility. Polym Degrad Stab 2015;115:24-31.

Singh B, Sharma DK, Gupta A. In vitro release dynamics of thiram fungicide from starch and poly(methacrylic acid) based hydrogels. J Hazard Mater 2008;154:1-3.