A REVIEW ON PHYTOPHARMACOLOGICAL ACTIVITY OF ALPINIA GALANGA

Authors

  • Shimaila Eram Faculty of Pharmacy, Integral University, Lucknow, (UP).
  • Md. Mujahid Faculty of Pharmacy, Integral University, Lucknow, (UP).
  • Paramdeep Bagga Faculty of Pharmacy, Integral University, Lucknow, (UP).
  • MUHAMMAD ARIF Faculty of Pharmacy, Integral University, Lucknow, (UP).
  • Md. Afroz Ahmad Faculty of Pharmacy, Integral University, Lucknow, (UP).
  • Arun Kumar Faculty of Pharmacy, Integral University, Lucknow, (UP).
  • Farogh Ahsan Faculty of Pharmacy, Integral University, Lucknow, (UP).
  • Md. Sohel Akhter Faculty of Pharmacy, Integral University, Lucknow, (UP).

DOI:

https://doi.org/10.22159/ijpps.2019v11i3.31352

Keywords:

Alpinia galanga, pharmacology, phytochemistry, traditional use, Chemical constituent

Abstract

Alpinia galanga plant which is associated with family Zingiberaceae is mainly scattered in tropical areas and widely known for ethno medicine. Against fungi and bacteria rhizome extract have a maximum inhibitory effect. Alpinia galanga plant is used in medicine and in food preparation. Rhizome extract of Alpinia galanga have high phenolic and flavonoid contents when compared to leaf extract. Because of elevated phenolic and flavonoid content in rhizome extract of Alpinia galanga there is noticeable antimicrobial as well as radical scavenging potential. It is a well-known official drug thought out the country as integrated contribution of nature. It is commonly used for the management of eczema, coryza, bronchitis, otitis interna, gastritis, ulcers, morbilli and cholera, pityriasis versicolor, to clear the mouth, emaciation. The different parts of the plant have various effects like antifungal, antiprotozoal, antiplatelet, antiviral, antidiabetic, immunomodulatory, antibacterial, anti-oxidant effects, hypolipidemic and many others. The essential oil of A. galanga identified 1, 8-cineol as a bioactive agent having antifeeding activity. An aqueous acetone extract of fruit of Alpinia galanga shows inhibitory effect on melanogenesis (formation of melanin). By using different methods, active constituent namely, 1'-acetochavicol acetate in hexane extract of Alpinia galanga rhizome was investigated for their corrosion inhibition properties. The current review add significant information about its, pharmacological activities, medicinal properties and phytochemical investigations as a traditional drug to cure for a number of diseases. Every fraction of the plant has valuable properties that can deliver humanity. The complete plant will be broadly investigated for further future prospective.

Downloads

Download data is not yet available.

References

Wyk B van, Wink M. Phytomedicines, herbal drugs, and poisons. Chicago: University of Chicago Press; 2015.

Vaidya ADB, Devasagayam TPA, Bhavan BV, Prakashananda S. Current status of herbal drugs in India: an overview. J Clin Biochem Nutr 2007;41:1–11.

Jantan I bin, Yassin MSM, Chin CB, Chen LL, Sim NL. Antifungal activity of the essential oils of nine zingiberaceae species. Pharm Biol 2003;41:392–7.

Verma RK, Mishra G, Singh P, Jha KK, Khosa RL. Alpinia galanga-an important medicinal plant: a review. Der Pharm Sin 2011;2:142–54.

Baldo DEB, Serrano JE, Diomerl C, Baldo EB. Screening for the intestinal anti-inflammatory activity of Alpinia galanga against acetic acid-induced colitis in mice (Mus musculus). J Med Plants Stud 2016;4:72–7.

Indrayan A, Agrawal P, Rathi A, Shatru A. Nutritive value of some indigenous plant rhizomes resembling ginger. Nat Prod Radiance 2009;8:507–13.

Chudiwal AK, Jain DP, Somani RS. Alpinia galanga Willd.-An overview on phytopharmacological properties. Ind J Nat Prod Res 2010;1:143-9.

Sharma PK, Singh V, Ali M, Kumar S. Evaluation of antinociceptive and anti-inflammatory activities of methanolic extract of alpinia galanga rhizomes in animal models. Int J Pharm Sci Res 2015;6:3103–8.

Jaju S, Indurwade N, Sakarkar D, Fuloria N, Al M. Isolation of galangogalloside from rhizomes of Alpinia galanga. Int J Green Pharm 2009;3:144–7.

Singh YR, Kalita JC. Effects of the methanolic extract of alpinia galanga from manipur (India) on the uterus of ovariectomised C3H albino mice. Int Res J Pharm 2012;3:423–7.

Srividya A, Dhanabal S, Satish kumar MN, Parth Kumar HB. Antioxidant and antidiabetic activity of alpinia galanga. Int J Pharmacogn Phytochem Res 2010;3:6–12.

Saha S, Banerjee S. Central nervous system stimulant actions of Alpinia galanga (L.) rhizome: a preliminary study. Indian J Exp Biol 2013;51:828–32.

Garg S, Gupta D, Sadhidhara K, Meha V. Alpinia galanga L.-composition of essential oil from flowers. Indian Perfum 2003;47:147–9.

Arambewela L, Wijesinghe A. Srilankan medicinal plant monographs and analysis, alpinia galanga. 10th ed. Colombo: Industrial Technology Institute and National Science Foundation; 2006.

Ravindran P, Pillai G, Babu K, Divakaran M, Malhothra S, Ochatt S, et al. Minor and under-utilized spices and herbs. Breed Neglected Under-Utilized Crop Spices Herbs 2007;1:299–373.

Scheffer J. Monoterpenes in the essential rhizome oil of Alpinia galanga (L.) Willd. Sci Pharm 1981;49:337–46.

Rastogi RP, Mehrotra BN, Sinha S, Pant P, Seth R, (India) CDRI, et al. Compendium of Indian medicinal plants. New Delhi: Central Drug Research Institute and Publications and Information Directorate; 1990.

Lee CC, Houghton P. Cytotoxicity of plants from Malaysia and Thailand used traditionally to treat cancer. J Ethnopharmacol 2005;100:237–43.

Lo CY, Liu PL, Lin LC, Chen YT, Hseu YC, Wen ZH, et al. Antimelanoma and antityrosinase from Alpinia galanga constituents. Sci World J 2013;3:186505.

Ito K, Nakazato T, Murakami A, Yamato K, Miyakawa Y, Yamada T, et al. Induction of apoptosis in human myeloid leukemic cells by 1-acetoxychavicol acetate through a mitochondrial-and fas-mediated dual mechanism. Clin Cancer Res 2004;10:2120–30.

Matsuda H, Morikawa T, Managi H, Yoshikawa M. Antiallergic principles from Alpinia galanga: structural requirements of phenylpropanoids for inhibition of degranulation and release of TNF-alpha and IL-4 in RBL-2H3 cells. Bioorg Med Chem Lett 2003;13:3197–202.

Phitak T, Choocheep K, Pothacharoen P, Pompimon W, Premanode B, Kongtawelert P. The effects of p-hydroxycinnamaldehyde from Alpinia galanga extracts on human chondrocytes. Phytochemistry 2009;70:237–43.

Roy SK, Pahwa S, Nandanwar H, Jachak SM. Phenylpropanoids of Alpinia galanga as efflux pump inhibitors in mycobacterium smegmatis mc2 155. Fitoterapia 2012;83:1248–55.

In L LA, Arshad NM, Ibrahim H, Azmi MN, Awang K, Nagoor NH. 1’-Acetoxychavicol acetate inhibits the growth of human oral carcinoma xenograft in mice and potentiates cisplatin effect via proinflammatory microenvironment alterations. BMC Complement Altern Med 2012;12:1144.

Latha C, Shriram VD, Jahagirdar SS, Dhakephalkar PK, Rojatkar SR. Antiplasmid activity of 1′-acetoxychavicol acetate from Alpinia galanga against multi-drug resistant bacteria. J Ethnopharmacol 2009;123:522–5.

Turker A, Usta C. Biological activity of some medicinal plants sold in turkish health-food stores. Biotechnol Biotechnol Equip 2006;20:105–13.

Tachakittirungrod S, Chowwanapoonpohn S. Comparison of antioxidant and antimicrobial activities of essential oils from hyptis suaveolens and alpinia galanga growing in Northern Thailand. C J Nat Sci 2007;6:31–42.

Hsu WY, Simonne A, Weissman A, Kim JM. Antimicrobial activity of greater galanga [Alpinia galanga (Linn.) Swartz.] flowers. Food Sci Biotechnol 2010;19:873–80.

Oonmetta Aree J, Suzuki T, Gasaluck P, Eumkeb G. Antimicrobial properties and action of galanga (Alpinia galanga Linn.) on staphylococcus aureus. LWT-Food Sci Technol 2006;39:1214–20.

Ficker CE, Smith ML, Susiarti S, Leaman DJ, Irawati C, Arnason JT. Inhibition of human pathogenic fungi by members of Zingiberaceae used by the Kenyah (Indonesian Borneo). J Ethnopharmacol 2003;85:289–93.

Trakranrungsie N, Chatchawanchonteera A, Khunkitti W. Ethnoveterinary study for an antidermatophytic activity of Piper betle, alpinia galanga and allium ascalonicum extracts in vitro. Res Vet Sci 2008;84:80–4.

Khattak S, Saeed-Ur-Rehman, Ullah Shah H, Ahmad W, Ahmad M. Biological effects of indigenous medicinal plants curcuma longa and Alpinia galanga. Fitoterapia 2005;76:254–7.

Taechowisan T, Lumyong S. Activity of endophytic actinomycetes from roots of zingiber officinale and alpinia galanga against phytopathogenic fungi. Artic Ann Microbiol 2003;53:291–8.

Sawangjaroen N, Subhadhirasakul S, Phongpaichit S, Siripanth C, Jamjaroen K, Sawangjaroen K. The in vitro anti-giardial activity of extracts from plants that are used for self-medication by AIDS patients in southern Thailand. Parasitol Res 2005;95:17–21.

Sawangjaroen N, Phongpaichit S, Subhadhirasakul S, Visutthi M, Srisuwan N, Thammapalerd N. The anti-amoebic activity of some medicinal plants used by AIDS patients in southern Thailand. Parasitol Res 2006;98:588–92.

Kaur A, Singh R, Dey CS, Sharma SS, Bhutani KK, Singh IP. Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) willd. Indian J Exp Biol 2010;48:314–7.

Qureshi S, Shah AH, Ahmed MM, Rafatullah S, Bibi F, Al-Bekairi AM. Effect of alpinia galanga treatment on cytological and biochemical changes induced by cyclophosphamide in mice. Int J Pharmacogn 1994;32:171–7.

Satish R, Dhananjayan R. Evaluation of anti-inflammatory potential of the rhizome of alpinia galanga linn. Biomedicine 2003;23:91–6.

Nagashekhar M, Shivprasad H. Anti-inflammatory and analgesic activity of the topical preparation of alpinia galanga willd. Biomed Contents 2005;1:63–9.

Jaju S, Indurwade N, Sakarkar D, Fuloria N, Ali M, Das S, et al. Galangoflavonoid isolated from the rhizome of alpinia galanga (L) Sw (Zingiberaceae). Trop J Pharm Res 2010;8:545–50.

Pompimon W, Jomduang J, Prawat U, Mankhetkorn S. Anti-phytopthora capsici activities and potential use as an antifungal in agriculture of alpinia galanga swartz, curcuma longa linn, boesenbergia pandurata schut and chromolaena odorata: bioactivities guided isolation of active ingredients. Am J Agric Biol Sci 2009;4:83–91.

Mahae N, Chaiseri S. Antioxidant activities and antioxidative components in extracts of alpinia galanga (L.) Nat Sci 2009;43:358-69.

Wong LF, Lim YY, Omar M. Antioxidant and antimicrobial activities of some alpina species. J Food Biochem 2009;33:835–51.

Melanathuru V, Rengarajan S, Thangavel N. Comparative study of the antioxidant and anticancer activity of alpinia calcarata and alpinia galanga. Int J Pharm Pharm Sci 2017;9:186–93.

Jantan I, Rafi IAA, Jalil J. Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. Phytomed 2005;12:88–92.

Akhtar RA, Reddy AB, Maywood ES, Clayton JD, King VM, Smith AG, et al. Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr Biol 2002;12:540–50.

Ye Y, Li B. 1’S-1’-acetoxychavicol acetate isolated from alpinia galanga inhibits human immunodeficiency virus type 1 replication by blocking rev transport. J Gen Virol 2006;87:2047–53.

Bendjeddou D, Lalaoui K, Satta D. Immunostimulating activity of the hot water-soluble polysaccharide extracts of anacyclus pyrethrum, alpinia galanga, and citrullus colocynthis. J Ethnopharmacol 2003;88:155–60.

Itokawa H, Morita H, Midorikawa I, Aiyama R, Morita M. Diarylheptanoids from the rhizome of Alpinia officinarum hance. Chem Pharm Bull 1985;33:4889–93.

Ravichandra V, Hanumantharayappa B, Papasani MRV. Evaluation of the cardioprotective activity of galangin against doxorubicin-induced cardiomyopathy. Int J Pharm Pharm Sci 2014;6:86–90.

Jain AP, Pawar RS, Lodhi S, Singhai AK. An immunomodulatory and anti-oxidant potential of alpinia galanga linn. rhizomes. Pharmacogn Commun 2012;2:30–7.

Arambewela LSR, Arawwawala LDAM, Ratnasooriya WD. Antinociceptive activities of aqueous and ethanolic extracts of Alpinia calcarata rhizomes in rats. J Ethnopharmacol 2004;95:311–6.

Patil NP, Bhapkar PH, Maheshwari KM, Jagtap PN, Shewale AP, Patil RY. Anthelmintic activity of aqueous extracts of the alpinia galanga willd Rh. Int J Pharm Sci Rev Res 2014;25:72–5.

Qureshi S, Shah A, Ageel A. Toxicity studies on alpinia galanga and curcuma longa. Planta Med 1992;58:124–7.

Unnisa A, Parveen TD. Anti-inflammatory and acute toxicity studies of the extracts from the rhizomes of alpinia galanga willd. Der Pharm Sin 2012;2:361–7.

Subash K, Bhaarathi MG, Rao JN, Vargheese Cheriyan B. Phytochemical screening and acute toxicity study of an ethanolic extract of alpinia galanga in rodents. Int J Med Res Heal Sci 2012;2:93–100.

Peter KV. Handbook of herbs and spices. Vol. 3. Newyork: Woodhead; 2006.

Published

01-03-2019

How to Cite

Eram, S., M. Mujahid, P. Bagga, M. ARIF, M. A. Ahmad, A. Kumar, F. Ahsan, and M. S. Akhter. “A REVIEW ON PHYTOPHARMACOLOGICAL ACTIVITY OF ALPINIA GALANGA”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 11, no. 3, Mar. 2019, pp. 6-11, doi:10.22159/ijpps.2019v11i3.31352.

Issue

Section

Review Article(s)

Most read articles by the same author(s)