INVESTIGATION OF THE ANTIBIOTIC RESISTANCE: THE CASE OF BUU DIEN GENERAL HOSPITAL IN HO CHI MINH CITY

Tran-Thi Ngoc-Van; Tran Quang-Thinh; Cu Thanh-Tuyen; Hoang-Thy Nhac-Vu

doi:10.22159/ijpps.2019v11i7.32913

Authors

Tran-Thi Ngoc-Van Medical College of Quang Nam http://orcid.org/0000-0002-4956-6166
Tran Quang-Thinh Buu Dien General Hospital in Ho Chi Minh City, Vietnam
Cu Thanh-Tuyen University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
Hoang-Thy Nhac-Vu University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam

DOI:

https://doi.org/10.22159/ijpps.2019v11i7.32913

Keywords:

Antibiotics, Resistance pattern, Buu Dien, General Hospital in HCM city

Abstract

Objective: In Vietnam, antibiotic resistance has been gained the attention of medical professionals in antibiotic use management. This study aimed to investigate the antibiotic resistance among hospital-acquired infections at Buu Dien General Hospital in Ho Chi Minh City in the period of 01-12/2017.

Methods: This cross-sectional descriptive study was conducted on the retrospective data of all antibiograms of bacteria isolated from hospital-acquired infections at Buu Dien General Hospital in Ho Chi Minh City in the period of 01-12/2017 to investigate the antibiotic resistance. Characteristics of antibiotic resistance were described by frequency and percentage of types of bacteria isolated and antibiotics being resistant.

Results: A total of 179 isolates were collected during the period 01-12/2017, of which E. coli was the most commonly isolated pathogen (41.3%). The highest prevalent infections were in the skin and mucosa; respiratory tract; and urinary tract (34.6%; 32.4%; and 27.9%). The antibiotic susceptibility testing used 21 types of antibiotics. Among them, S. aureus was 82% resistant to clindamycin and 75% resistant to cefuroxime; the Proteus resistance percentages to amoxicillin/clavulanic, second-generation cephalosporins, ciprofloxacin and fosfomycin varied from 50 to 93%; Pseudomonas was 92% resistant to fosfomycin and 62% resistant to ceftazidime; A. baumannii was resistant to most classes of agents used (50-75%). Both E. coli and Klebsiella were highly resistant to gentamicin, amoxicillin, ciprofloxacin, 2^nd and 3^rd generation cephalosporin’s. Polymyxin B-resistant Proteus cultures were detected at 67%.

Conclusion: The study described the antibiotic resistance situation of hospital-acquired bacteria at the Buu Dien General Hospital from 01-12/2017. This information will aid physicians to select proper antibiotics for their patients in the next period.

Downloads

Download data is not yet available.

References

World Health Organization. Regional Office for South-East Asia (2016). Situation analysis on antimicrobial resistance in the South-East Asia Region: Report; 2016.

Nhac Vu HT, Bao Tran TD. Surveying the tendency of combining antibiotics for inpatients: an analysis of combinations of injectable antibiotics in 11 district hospitals in an-giang province. Y hoc Tp. Ho Chi Minh 2017; Suppl 21:42-6.

Vietnamese Ministry of Health (MOH). Report on the use of antibiotics and antibiotic resistance in 15 hospitals in Vietnam 2008-2009. Ha Noi; 2010.

Truong TA, Rahman M, Coffin S, Harun-Or-Rashid, Sakamoto J, Nguyen VH. Antibiotic use in vietnamese hospitals: a multicenter point-prevalence study. Am J Infect Control 2012;40:840-4.

GARP-Vietnam National Working Group. Situation analysis: Antibiotic Use and Resistance in Vietnam. Ha Noi; 2010.

Vietnamese Ministry of Health (MOH). Ratification of the national action plan to combat antimicrobial resistance from 2013 to 2020. Ha Noi; 2013.

Vietnamese Ministry of Health (MOH). Technical guidelines for specialized microbiology. Ha Noi; 2013.

Tran TTT, Tran VN, Tran TTN. Relationship between vancomycin MIC and effective treatment among patients with methicillin‐resistant Staphylococcus aureus. Y hoc Tp. Ho CHi Minh 2014;18:268-72.

Pham HV, The MIDAS. The multicenter study on the resistance to imipenem and meropenem of the the non-fastidious gram (-) rods–the results from 16 hospitals in Vietnam. Y hoc Tp. Ho CHi Minh 2010;14:280-6.

Divyashanthi CM, Adithiyakumar S, Bharathi N. Study of prevalence and antimicrobial susceptibility pattern of bacterial isolates in a tertiary care hospital. Int J Pharm Pharm Sci 2014;7:185-90.

Wikaningtyas P, Joseph S, Elin S, Indahwaty G. Profile of antibiotic resistance and usage pattern in ICU of private hospital in Bandung, Indonesia. Iin J Pharm Pharm Sci 2015;7:160-2.

Pham THA, Vu LNL, Uong NDN, Phan NT, Cao HN. Surveying the antibiotic resistance of Klebsiella pneumoniae in isolated specimens in pasteur institute-ho chi minh city. J Sci Ho Chi Minh City University Education 2014;61:146-55.

Tran HH, Heiman W, Tran ND, Nguyen BM, Tran VP, Trinh HS, et al. Gram negative bacteria carrying New Delhi-Metallo-Beta-Lactamase (NDM-1) gene isolated in the hospital environment. J Med Res 2013;85:1-8.

Tran HH, Nguyen HT, Nguyen BM, Tran ND, Tran VP, Pham DT, et al. First report on Citrobacter freundii carrying New Delhi-Metallo-beta-lactamase (NDM-1) gene resitant to carbapenem isolated in hospital from 2010-2011. J Preventive Med 2012;VI:23-30.