EFFECT OF FUCITHALMIC AND SOFINOX EYE DROPS ON EXPERIMENTAL ALLERGIC CONJUNCTIVITIS IN RATS

Authors

  • Shakta Mani Satyam Department of Pharmacology, Melaka Manipal Medical College, Manipal University, Manipal-576104, Karnataka (India)
  • Shalini Adiga Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka (India)
  • Bharti Chogtu Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka (India)
  • LAXMINARAYANA BAIRY K. Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka (India)
  • Rajadurai Pirasanthan Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka (India)
  • Rajdip Lalith Vaishnav Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka (India)

Keywords:

Allergic conjunctivitis, Sofinox, Fucithalmic, IgE

Abstract

Objective: To investigate the therapeutic effect of Fucithalmic 1%, Sofinox 0.5% and 1% eye drops against an IgE-mediated allergic conjunctivitis model in Wistar rats.

Methods: IgE-mediated allergic conjunctivitis was induced by ovalbumin antigen challenge. Allergic conjunctivitis induced control rats (Group I) received normal saline (0.9% NaCl; 10 µl/eye) whereas Fucithalmic 1% (Group II), Sofinox 0.5% (Group III) and 1% (Group IV) were administered as 10, 20 and 10 µl/eye respectively to the treatment group animals (n=6) for 15 days. Eye scratching behavior, hypothermia and edema was evaluated after topical antigen challenge.

Results: Sofinox 1% eye drops (10 µl/eye) significantly attenuated eye scratching behavior, hyperemia and edema in comparison with allergic conjunctivitis induced control (p < 0.001) and Fucithalmic 1% treated rats (p < 0.05). Eye scratching behavior and edema was also significantly decreased in Sofinox 0.5% eye drops (20 µl/eye) treatment group as compared to allergic conjunctivitis induced control rats (p < 0.05).

Conclusion: The present study revealed that the Sofinox eye drop is the potential agent that could offer a novel therapeutic opportunity against IgE-mediated allergic conjunctivitis in Wistar rats.

Downloads

Download data is not yet available.

References

Minami K, Chiaki K. A chronic model for evaluating the itching associated with allergic conjunctivitis in rats. Int Pharmacol 2004;4:101-8.

Groneberg DA, Bielory L. Animal models of allergic and inflammatory conjunctivitis. Allergy 2003;58:1101-13.

MihaI B. Current therapy of allergic conjunctivitis. Curr Ther Res 1997;58(11):1-11.

Christiansen K. Fusidic acid non-antibacterial activity. Int J Antimicrob Agents 1999;12(Suppl 2):S73-8.

Genovese F, Mancuso G, Cuzzola M, Cusumano V, Nicoletti F, Bendtzen K, et al. Improved survival and antagonistic effect of sodium fusidate on tumor necrosis factor alpha in a neonatal mouse model of endotoxin shock. Antimicrob Agents Chemother 1996;40:1733–5.

Osman MO, Elsefi T, Lausten SB, Jacobsen NO, Larsen CG, Jensen SL. Sodium fusidate and the cytokine response in an experimental model of acute pancreatitis. Br J Surg 1998;85(11):1487–92.

Katelaris CH. Allergic rhinoconjunctivitis: an overview. Acta Ophthalmol Scand 2000;230:66−8.

Proud D, Sweet J, Stein P, Settipane RA, Kagey SA, Friedlaender MH, et al. Inflammatory mediator release on conjunctival provocation of allergic subjects with allergen. J Allergy Clin Immunol 1990;85:896−05.

Published

01-11-2014

How to Cite

Satyam, S. M., S. Adiga, B. Chogtu, L. B. K., R. Pirasanthan, and R. L. Vaishnav. “EFFECT OF FUCITHALMIC AND SOFINOX EYE DROPS ON EXPERIMENTAL ALLERGIC CONJUNCTIVITIS IN RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 11, Nov. 2014, pp. 458-60, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/3324.

Issue

Section

Original Article(s)