CYTOTOXICITY STUDIES OF TETRAPRELYLTOLUQUINONE, A PRENILATED HYDROQUINONE FROM GARCINA COWA ROXB ON H-460, MCF-7 AND DU-145

Authors

  • Fatma Sri Wahyuni Faculty of Pharmacy, Andalas University, Kampus Limau Manis, Padang, West Sumatra, Indonesia, 25163
  • Johnson Stanslas Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 43400 UPM, Serdang, Selangor, Malaysia
  • Nordin Hj Lajis Laboratory of Natural Products, Institut of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.
  • Dachriyanus Hamidi Faculty of Pharmacy, Andalas University, Kampus Limau Manis, Padang, West Sumatra, Indonesia, 25163

Keywords:

Garcinia cowa, TPTQ, H-460, MCF-7, DU-145, Cell viability, Cytotoxicity

Abstract

Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines.

Methods: Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability.

Results: The results of this study showed that this compound has IC50 value 16.3 ± 3.0 µM in H-460 cancer cell lines without any activities towards another two type of cell lines.

Conclusion: TPTQ had selective activity against H-460 cancer cell lines.

 

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References

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Published

01-03-2015

How to Cite

Wahyuni, F. S., J. Stanslas, N. H. Lajis, and D. Hamidi. “CYTOTOXICITY STUDIES OF TETRAPRELYLTOLUQUINONE, A PRENILATED HYDROQUINONE FROM GARCINA COWA ROXB ON H-460, MCF-7 AND DU-145”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 3, Mar. 2015, pp. 60-63, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/3637.

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