FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF LAMOTRIGINEUSING DISCRETE SUPER DISINTEGRANTS AND COPROCESSED EXCIPIENTS

RAJASEKHAR POONURU; ROHINI CHERUKU; PAVAN JULURI; KHADEERA JABEEN; SWETHA SREERAMULA; SNEHA BANDARI; AKHILA MADUPU

doi:10.22159/ijpps.2020v12i6.37567

Authors

RAJASEKHAR POONURU Principal and Head, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
ROHINI CHERUKU Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
PAVAN JULURI Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
KHADEERA JABEEN Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
SWETHA SREERAMULA Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
SNEHA BANDARI Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
AKHILA MADUPU Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences

DOI:

https://doi.org/10.22159/ijpps.2020v12i6.37567

Keywords:

Tablets of lamotrigine using, Coprocessed excipients

Abstract

Objective: The present study was designed to formulate and evaluate the orodispersible tablets of lamotrigine after enhancing its solubility.

Methods: Lamotrigine was made into an inclusion complex with eudragit E 100 my kneading and mass extrusion method and later this mixture is compressed into orodispersible tablet using various super disintegrants and co-processed excipients to reduce the disintegration time for providing prompt action through rapid drug release.

Results: Lamotrigine ODTs containing F-melt (F1-3%, F2-5%) dispersed in lesser time of (9±0.11) and (21±0.58) compared to formulations with polyplasdone XL-10 and primellose as super disintegrants respectively with F1 showing short wetting time. The water absorption was also was found to be more for formulation with 3% F-Melt.

Conclusion: Lamotrigine orodispersible tablets were prepared by direct compression technique by using 3% and 5% of three super disintegrants (f-melt, primellose and polyplasdone XL-10). Disintegration time of F1 (3% f-melt) formulation was found to be least (7 sec).

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References

Abdelbary A, Elshafeey AH, Zidan G. Comparative effects of different cellulosic-based directly compressed orodispersible tablets on oral bioavailability of famotidine. Carbohydrate Polymers 2009;77:799-806.

Ashwini R, Mangesh R, Rahul R. Formulation design and optimization of novel taste masked mouth-dissolving tablets of tramadol having adequate mechanical strength. AAPS PharmSciTech 2009;10:574-81.

Battu SK, Michael AR, Soumyajit M, Madhusudan Y. Formulation and evaluation of rapidly disintegrating fenoverine tablets: effect of superdisintegrants. Drug Dev Ind Pharm 2007;33:1225-32.

Bhatu PB, Atish M. The technologies used for developing orally disintegrating tablets: a review. Acta Pharm 2011;61:117–39.

Poonuru RR, Gonugunta CSR. Spatio temporal release of lamotrigine by buoyant gastroretentive drug delivery: development and evaluation. Int J Pharm Pharm Sci 2014;6:604-10.

Poonuru RR, Gonugunta CSR. Bimodal gastroretentive drug delivery systems of lamotrigine: formulation and evaluation. Indian J Pharm Sci 2014;76:476-82.

Poonuru RR, Gonugunta CSR. Development of buoyant controlled release drug delivery systems of atazanavir sulphate: effect of various diluents and lubricants on drug release. Pharm Int J Adv Pharm Sci 2014;5:1947-57.

Poonuru RR, Ramya SA, Rohini Ch, Pavan J, Lasya RE, Sasya A, et al. Development of sublingual tablets of losartan potassium with enhanced permeation through mucosa. J Med Pharm Sci 2020;1:38-43.

Poonuru RR, Abdul RA, Rohini Ch, Pavan J, Swetha S, Akhila M. Formulation and in vivo evaluation of mucoadhesive buccal tablet of fluvastatin sodium. Asian J Hosp Pharm 2020;1:35-45.

Poonuru RR. The dark side of clinical trials and remedial strategies in India. Asian J Hosp Pharm 2020;1:30-4.

Saurabh A, Balaji O, Amita Priya D, Mohan A, Meena K. Lamotrigine induced dress syndrome. Asian J Pharm Clin Res 2017;10:3-4.

Francesco C, Elisa C, Paola M, Susanna B, Chiara G, Luisa M. Diclofenac fast-dissolving film: suppression of bitterness by a taste-sensing system. Drug Dev Ind Pharm 2011;37:252–9.

Goel H, Arora A, Tiwary AK, Rana V. Development and evaluation of mathematical model to predict disintegration time of fast disintegrating tablets using powder characteristics. Pharm Dev Technol 2011;16:57-64.

Guptha A, Mishra AK, Guptha V, Bansal P, Singh R, Singh AK. Recent trends of fast dissolving tablet–an overview of formulation technology. Int J Pharm Bio Arch 2010;1:1-10.

James K. Dissolution testing of orally disintegrating tablets. Diss Tech 2003;10:6-8.

Jianchen X, Li B, Kang Z. Taste masking microspheres for orally disintegrating tablets. Int J Pharm 2008;359:63-9.

Kuno Y, Kojima M, Ando S, Nakagami H. Evaluation of rapidly disintegrating tablets manufactured by phase transition of sugar alcohols. J Controlled Release 2005;105:16-22.

Morita Y, Tsuhima Y, Yasui M, Termoz R, Ajioka J, Takayam K. Evaluation of the disintegration time of rapidly disintegrating tablets via a novel method utilizing CCD camera. Chem Pharm Bull 2002;50:1181-6.

Nishant V, Vikas R. Preparation and optimization of mouth/orally dissolving tablets using a combination of glycine, carboxymethyl cellulose and sodium alginate: a comparison with superdisintegrants. Pharm Dev Technol 2008;13:233-43.

Okuda Y, Irisawa Y, Okimoto K, Osawa T, Yamashita S. A new formulation for orally disintegrating tablets using a suspension spray-coating method. Int J Pharm 2009;382:80-7.

Rajan K, Sanjay G. Current status of drug delivery technologies and future directions. Pharm Tech 20011;25:1-14.

Rakesh P, Mona P, Prabodh C, Sharma, Dhirender K, Sanju N. Orally disintegrating tablets–friendly to pediatrics and geriatrics. Arch Pharm Res 2010;2:35-48.

Rosie ML, Susan B, Kieran C. Orally disintegrating tablets: the effect of recent FDA guidance on ODT technologies and applications. Pharm Technol 2009;5:1-6.

Shirwaikar AA. Fast disintegrating tablets of atenolol by dry granulation method. Ind J Pharm Sci 2004;66:422-6.

Mishra DN, Bindal M, Singh SK, Kumar SKV. Spray dried excipient base: a novel technique for the formulation of orally disintegrating tablets. Chem Pharm Bull 2006;54:99–102.

Mistry M. Application-related properties of a new fast dispersible excipient. Pharm Tech Eur 2009;2:24–7.

Gohel MC. A review of co-processed directly compressible excipients. J Pharm Pharm Sci 2005;8:76–93.

Satyajith P, Nodagala H, Panchagnula US, Srinivasa RB. Formulation and evaluation of orodispersible tablets (odts) of diclofenac sodium by using superdisintegrant from natural origin. Int J Appl Pharm 2019;11:190-7.

Sireesha P, R Kiranjyothi. Formulation and evaluation of antidepressant orodispersible tablets. Int J Curr Pharm Res 2016;8:52-60.

Dobetti L. Fast-melting tablets: developments and technologies. Pharm Tech Eur 2000;12:32–42.