SYNTHESIS, ANTIMICROBIAL, ANTIOXIDANT AND DOCKING STUDIES OF (3-METHOXY-5-NITROBENZOFURAN-2-YL)(PHENYL)METHANONE DERIVATIVES.SYNTHESIS, ANTIMICROBIAL, ANTIOXIDANT AND DOCKING STUDY OF (3-ALKOXY-5-NITROBENZOFURAN-2-YL) (PHENYL) METHANONE DERIVATIVES

Authors

  • S. K. Rashmi Jain University
  • T. H. Suresha Kumara Jain University
  • C. Sandeep Post Graduate department Of Chemistry Acharya Institute Of Graduate Studies (Affiliated to Bangalore University) Soladevanahalli, Bangalore 560090.
  • G. Nagendrappa Jain University
  • H. B. V. Sowmya Jain University
  • P. S. Sujan Ganapathy Jain University

Keywords:

(3-Alkoxy-5-nitrobenzofuran-2-yl)(phenyl) methanone, (3-hydroxy-5-nitrobenzofuran-2-yl)(phenyl) methanones, Antimicrobial activity, Antioxidant activity, Molecular docking studies

Abstract

Objective: Synthesis, antimicrobial, antioxidant and docking studies of (3-methoxy-5-nitrobenzofuran-2-yl)(phenyl)methanone derivatives (2a-j).

Methods: The products 2a-j, were obtained from different (3-hydroxy-5-nitrobenzofuran-2-yl)(phenyl)methanonesrefand alkyl bromides in the presence of K2CO3 in DMF at room temperature. Afterwards, characterised through 1H-NMR, [13]C-NMR, ESI-LCMS and elemental analyses. Finally, subjected them for antimicrobial and antioxidant studies through agar well diffusion technique and docking interaction studies through automated docking technique.

Results: From the current procedure, the compound 2a has showed the highest antibacterial activity and 2j showed lowest antibacterial activity. None of these (2a-j) have showed antifungal activity. The compound 2d has shown highest free radical scavenging activity and 2e has shown least activity. The biological properties of the synthesised compounds (2a-j) were further supported by docking studies.

Conclusion: Successfully synthesised and characterized ten individually novel (3-alkoxy-5-nitrobenzofuran-2-yl)(phenyl)methanone derivatives (2a-j) in one pot procedure and studied antimicrobial, antioxidant and docking properties. Perhaps the present work provides an evidence for the preparation, antimicrobial and antioxidant properties of the novel benzofuran derivatives.

 

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Author Biography

C. Sandeep, Post Graduate department Of Chemistry Acharya Institute Of Graduate Studies (Affiliated to Bangalore University) Soladevanahalli, Bangalore 560090.

Post Graduate department of chemistry

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Published

01-02-2015

How to Cite

Rashmi, S. K., T. H. S. Kumara, C. Sandeep, G. Nagendrappa, H. B. V. Sowmya, and P. S. S. Ganapathy. “SYNTHESIS, ANTIMICROBIAL, ANTIOXIDANT AND DOCKING STUDIES OF (3-METHOXY-5-NITROBENZOFURAN-2-YL)(PHENYL)METHANONE DERIVATIVES.SYNTHESIS, ANTIMICROBIAL, ANTIOXIDANT AND DOCKING STUDY OF (3-ALKOXY-5-NITROBENZOFURAN-2-YL) (PHENYL) METHANONE DERIVATIVES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 2, Feb. 2015, pp. 493-7, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/4041.

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