SOME BENZOXAZINE AND AMINOMETHYL DERIVATIVES OF EUGENOL: CYTOTOXICITY ON MCF-7 CELL LINE

Authors

  • Marcellino Rudyanto Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya 60286, Indonesia Institute of Tropical Disease, Airlangga University, Jalan Mulyorejo, Surabaya 60115, Indonesia
  • Tri Widiandani Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya 60286, Indonesia
  • Achmad Syahrani Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya 60286, Indonesia

Keywords:

Eugenol, Benzoxazines, Aminomethyl, Cytotoxicity, MCF-7

Abstract

Objective: The objective of this research is to examine in vitro cytotoxicity of some benzoxazine and aminomethyl derivatives of eugenol against the MCF-7 cancer cell line.

Methods: 6-Allyl-8-methoxy-3-phenyl-3,4-dihydro-2H-benzo[e][1,3]oxazine, 6-allyl-3-benzyl-8-methoxy-3,4-dihydro-2H-benzo[e][1,3]oxazine, 6-allyl-3-(furan-2-ylmethyl)-8-methoxy-3,4-dihydro-2H-benzo[e][1,3]oxazine, 4-allyl-2-methoxy-6-(phenylaminomethyl)phenol, 4-allyl-2-(benzylaminomethyl)-6-methoxyphenol, and 4-allyl-2-{[(furan-2-ylmethyl)amino]methyl}-6-methoxyphenol were subjected to cytotoxicity study using MTT assay and calculate the percent of cell viability.

Results: The obtained LC50 values of the tested compounds on MCF-7 cancer cell line are respectively 96.9±6.84, 26.4±2.68, 21.7±2.90, 58.4±4.42, 29.2±2.39, and 45.7±4.62 mg/ml.

Conclusion: All the tested compounds have cytotoxicity against the MCF-7 cell line.


  

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Author Biographies

Marcellino Rudyanto, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya 60286, Indonesia Institute of Tropical Disease, Airlangga University, Jalan Mulyorejo, Surabaya 60115, Indonesia

Head of Department of Pharmaceutical Chemistry  

Tri Widiandani, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya 60286, Indonesia

Lecturer, Department of Pharmaceutical Chemistry  

Achmad Syahrani, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya 60286, Indonesia

Professor, Department of Pharmaceutical Chemistry  

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Published

01-05-2015

How to Cite

Rudyanto, M., T. Widiandani, and A. Syahrani. “SOME BENZOXAZINE AND AMINOMETHYL DERIVATIVES OF EUGENOL: CYTOTOXICITY ON MCF-7 CELL LINE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 5, May 2015, pp. 229-32, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/4109.

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Original Article(s)