EFFECT OF TAMSULOSIN A SELECTIVE α1-ANTAGONIST ON GLUCOSE HOMEOSTASIS IN RATS

Authors

  • Gurudatta Moharir BLDEU's Shri BM Patil Medical College
  • Shivaprasad K BLDEU's Shri BM Patil Medical College
  • Ambadasu Bharatha BLDEU's Shri BM Patil Medical College
  • A A Naikawadi BLDEU's Shri BM Patil Medical College
  • Wali R. S. BLDEU's Shri BM Patil Medical College

Keywords:

Nil, Wistar rats, Streptozotocin

Abstract

Objective:  To assess the effect of tamsulosin (α1-antagonist) on blood sugar and adrenaline levels in rats.

Methods: Wistar rats were divided in to four groups (n=6), Group-I (Normal control) administered normal saline, Group-II, Group-III &Group-IV induced diabetes by administering Streptozotocin IV 50 mg/kg. Group III and Group-IV were administered Tamsulosin 1mg/kg and Glimepiride 10µg/kg respectively for twenty one days. Serum insulin, adrenaline and blood glucose were estimated at before and after drug treatment.

Results: Adrenaline and insulin levels were increased significantly (p<0.005) in Diabetic control and Tamsulosin treated diabetic rats compared to Normal control rats. Blood glucose levelsincreased significantly (p<0.005) in Tamsulosin treated diabetic rats compared to Diabetic control rats. All the three parameters are compared at the end of drug treatment.

Conclusion: Several studies interpreted a potential role of the α-receptor in glucose metabolism. Inhibition of the α1-receptor pathway can lead to a decreased glucose uptake, and hence an increased plasma glucose concentration. Several studies in one or the other way indicating the correlation between diabetes and BPH and probably in such condition tamsulosin a α1 antagonist is the drug of choice along with oral hypoglycemic agents. Literature survey also shows that there is increase in the blood glucose levels during the use of tamsulosin which impacts blood sugar levels especially in diabetic state. T.h.is study shows increase in blood glucose levels with the use of tamsulosin is making further complications in diabetic patients. This adverse drug reaction and the proposed mechanism need to be proven further.

 

Downloads

Download data is not yet available.

Author Biographies

Gurudatta Moharir, BLDEU's Shri BM Patil Medical College

Lecturer

Dept of Pharmacology

Shivaprasad K, BLDEU's Shri BM Patil Medical College

Asst Professor

Dept of Pharmacology

Ambadasu Bharatha, BLDEU's Shri BM Patil Medical College

Lecturer

Dept of Pharmacology

A A Naikawadi, BLDEU's Shri BM Patil Medical College

Professor

Dept of Pharmacology

Wali R. S., BLDEU's Shri BM Patil Medical College

Professor & Head

Dept of pharmacology

References

Joshi SR, Parikh RM. India-diabetes capital of the world: now heading towards hypertension. J Assoc Physicians India 2007;55:323-4.

Kumar A, Goel MK, Jain RB, Khanna P, Chaudhary V. India towards diabetes control: Key issues. Australas Med J 2013;6(10):524-31.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27(5):1047-53.

Lee C, Kozlowski JM, Grayhack JT. Etiology of benign prostatic hyperplasia. Urologic Clin North Am 1995;22(2):237-46.

Partin W, Oesterling JE, Epstein JI, Horton R, Walsh PC. Influence of age and endocrine factors on the volume of benign prostatic hyperplasia. J Urol 1991;145(2):405-9.

Farese RV. Insulin-sensitive phospholipid signaling systems and glucose transport. Update II Exp Biol Med 2001;226(4):283-95.

Hutchinson DS, Bengtsson T. Alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C, phosphati-dylinositol-3 kinase, and atypical protein kinase C-dependent pathway. Endocrinol 2005;146(2):901-2.

Cheng JT, Liu IM, Yen ST, Chen PC. Role of alpha1A-adrenoceptor in the regulation of glucose uptake into white adipocyte of rats in vitro. Auton Neurosci 2000;84(3):140-6.

Faintrenie G, Geloen A. Alpha-1 adrenergic stimulation of glucose uptake in rat white adipocytes. J Pharmacol Exp Ther 1998;286(2):607-10.

Zhong H, Minneman KP. Alpha1-adrenoceptor subtypes. Eur J Pharmacol 1999;375(1-3):261-76.

Boschmann M, Krupp G, Luft FC, Klaus S, Jordan J. In vivo response to alpha1-adrenoreceptor stimulation in human white adipose tissue. Obes Res 2002;10(6):555-8.

Flechtner-Mors M, Jenkinson CP, Alt A, Biesalski HK, Adler G, Ditschuneit HH. Sympathetic regulation of glucose uptake by the alpha1-adrenoceptor in human obesity. Obes Res 2004;12(4):612-20.

Bourke JB, Griffin JP. Hypertension, diabetes mellitus, and blood groups in benign prostatic hypertrophy. Br J Urol 1966;38(1):18-23.

Hammarsten J, Högstedt B, Holthuis N, Mellstrom D. Components of the metabolic syndrome-risk factors for the development of benign prostatic hyperplasia. Prostate Cancer Prostatic Dis 1998;1(3);157-62.

Safarinejad MR. Prevalence of benign prostatic hyperplasia in a population-based study in Iranian men 40 years old or older. Int Urol Nephrol 2008;40(4):921-31.

Sarma AV, Burke JP, Jacobson DJ, McGree ME, St Sauver J, Girman, et al. Associations between diabetes and clinical markers of benign prostatic hyperplasia among community-dwelling black and white men. Diabetes Care 2008;31(3):476–82.

Adeghate E, Ponery AS, Sheen R. Streptozotocin-Induced diabetes mellitus is associated with increased pancreatic tissue levels of noradrenaline and adrenaline in the rat. Pancreas 2001;22(3):311-6.

Published

01-03-2015

How to Cite

Moharir, G., S. K, A. Bharatha, A. A. Naikawadi, and W. R. S. “EFFECT OF TAMSULOSIN A SELECTIVE α1-ANTAGONIST ON GLUCOSE HOMEOSTASIS IN RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 3, Mar. 2015, pp. 232-4, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/4268.

Issue

Section

Original Article(s)