FORMULATION AND DEVELOPMENT OF PRONIOSOMAL GEL FOR TOPICAL DELIVERY OF AMPHOTERICIN B

REESHA PARVEZ BAIG; MOHAMMAD WAIS

doi:10.22159/ijpps.2022v14i1.43237

Authors

REESHA PARVEZ BAIG Department of Pharmaceutics, H. K. College of Pharmacy, Relief Road, Pratiksha Nagar, Oshiwara, Jogeshwari West, Mumbai 400102, India https://orcid.org/0000-0001-6749-8665
MOHAMMAD WAIS Department of Pharmaceutics, H. K. College of Pharmacy, Relief Road, Pratiksha Nagar, Oshiwara, Jogeshwari West, Mumbai 400102, India

DOI:

https://doi.org/10.22159/ijpps.2022v14i1.43237

Keywords:

Amphotericin B, Proniosomal gel, Cholesterol, Carbopol, Topical, Fungal infection

Abstract

Objective: The present research work of Amphotericin B Proniosomal gel focuses on improving patient compliance by reducing the side effects of conventional intravenous injections and minimizing the problem of physical stability and to localize drug at site of action.

Methods: Proniosomal gels are prepared by coacervation phase separation technique using different concentration of non-ionic surfactants (Span and Tween) for uniform vesicle formation, lecithin as permeation enhancer/membrane stabilizer and cholesterol as a vesicle cement providing prolonged release. Prepared gels were evaluated for their viscosity, pH, spreadability, entrapment efficiency, drug content uniformity, extrudability, in vitro drug release, permeability and stability studies.

Results: Among the nine formulations, F2 (containing 10 mg drug, 250 mg Span 60, 50 mg Soya lecithin) was found to be promising. Fourier Transform infra-red (FT-IR) spectra studies represented no interaction and physicochemical characteristics were found within the limits. The percentages of drug content and entrapment efficiency were determined to be 95.16%±0.40 and 94.20%±0.20, respectively. In vitro drug release was about 95.72%±0.30.

Conclusion: Proniosomal gel could constitute a promising approach for topical delivery of Amphotericin B by encapsulating it in non-ionic surfactant to provide patient compliance with cutaneous fungal infection, which was found to be safe, tolerable and efficacious.

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