GASTROPROTECTIVE POTENTIAL OF LASIA SPINOSA IN ALBINO RATS

Authors

  • Mohammed Atif SHADAN COLLEGE OF PHARMACY, DEPARTMENT OF PHARMACOLOGY
  • Mohammed Azharuddin Nizam Institute of Pharmacy
  • Syed Baquer Mahmood Shadan College of Pharmacy

Keywords:

Gastro protective, Lasia spinosa, Ranitidine, Stomach

Abstract

Objective: The intent of the present study was to assess the gastroprotective impact of Lasia spinosa leaf ethanolic concentrate (LSEE) by method of Indomethacin and Cold Restrain stress induced Ulcers in Albino rats. Lasia spinosa is a plant found in Assam on rough slope top of dry deciduous timberlands.

Methods: Indomethacin 5mg/kg body weight p. o; for five days and Cold restraint stress models, were utilized for actuating gastric ulcers in rats. Biochemical parameters such as Glutathione, Malondialdehyde, acidity, Gastric volume, gastric pH were determined in order to assess the gastro protective activity of LSEE in both the models.

Results: Treatment of rats with Indomethacin and subjecting them to Cold restraint stress (CRS) elevated the levels of Gastric volume, acidity, Glutathione, Malondialdehyde and gastric pH in negative control group in comparison with normal group. The elevated levels were significantly reversed when treated with standard drug Ranitidine 50 mg/kg body weight p. o; and Lasia spinosa leaf ethanolic extracts (LSEE).

Conclusion: All in all it can be expressed that Lasia spinosa leaf ethanolic concentrates demonstrated a critical inversion of ulcerative parameters. It could be imagined that it applies its action because of the vicinity of flavonoids which have been accounted for to secure the mucosa by development of a defensive layer.

 

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Author Biography

Mohammed Atif, SHADAN COLLEGE OF PHARMACY, DEPARTMENT OF PHARMACOLOGY

DEPARTMENT OF PHARMACOLOGY, STUDENT

References

Agyare C. An Ethnopharmacological survey and in vitro confirmation of Ethnopharmacological use of medicinal plants used for wound healing in Bosomtwi-Atwima-Kwanwoma area, Ghana. J Ethnopharmacol 2009;125(3):393-403.

Rivlin RS. Historical perspective on the use of garlic. J Nutr 2001;131(3s):951-4.

Bhattacharya A, Ghosal S, Bhattacharya SK. Anti-oxidant effect of Withania somnifera glycowithanolides in chronic foot shock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. J Ethnopharmacol 2001;74:1–6.

http://digestive.niddk.nih.gov/ddiseases/pubs/pepticulcers_ez/pepticulcers. pdf [Accessed on March 23rd 2013].

Shefana AG, Ekanayake S. Some Nutritional aspects of Lasia spinosa (Kohila). Vidyodaya J Sci 2009;14:1.

Medicinal Plant database of Bangladesh, Lasia spinosa Thw. Available from: (http://www.mpbd.info/plants/lasia-spinosa.php)

Goshwami Durajan, Abdul Muhit, Saiful Islam, Lasia spinosa. An Ethnopharmacological Investigation. Lambert Academic Publishing; 2012.

Nadkarni KM. Indian materia médica. 3rd Edition. Bombay, India: Popular Book Depot, Bombay & Dhootpapeshwar Prakashan Ltd: Plant number; 1955. p. 1038, 548.

Kulkarni SK. Handbook of experimental pharmacology. 2nd ed. Vallabh Prakashan, Mumbai; 1993.

Kokate CK. A textbook of pharmacognosy. 45th ed. Vallabh Prakashan, New Delhi; 2010.

Khandelwal KR. Practical pharmacognosy techniques and experiments. 2nd edition. Nirali Prakashan, Pune; 2000. p. 149-56.

Trease GE, Evans WC. A textbook of pharmacognosy. 13th edition. Bailliere Tindall Ltd: London; 1989.

Biswajit Majumdar. Effect of ethanol extract of Piper betle Linn leaf on healing of NSAID–induced experimental ulcer–A novel role of free radical scavenging action. Indian J Exp Biol 2003;41;311-5.

Vandana Panda, Madhav Sonkamble. Anti-ulcer activity of Ipomoea batatas tubers (sweet potato). Funct Foods Health Dis 2012;2(3):48-61.

http://en.wikipedia.org/wiki/Indometacin. [Accessed on March 25th 2013].

Takeuchi K, Ueki S, Tanaka H. Endogenous prostaglandins in gastric alkaline response in the rat stomach after damage. Am J Physiol 1986;250:G842–G849.

Lichtenberger LM, Romero JJ, Dial EJ. Surface phospholipids in gastric injury and protection when a selective cyclooxygenase-2 inhibitor (Coxib) is used in combination with aspirin. Br J Pharmacol 2007;150:913–9.

Deore A, Sapakal V, Dashputre N, Naikwade N. Antiulcer activity of Garcinia indica linn fruit rinds. J Appl Pharm Sci 2011;1(5):151-4.

Brodie DAQ, Hanson HM. A study of the factors involved in the production of gastric ulcer by the restraint technique. Gastroenterol 1960;38:353–60.

Published

01-03-2015

How to Cite

Atif, M., M. Azharuddin, and S. B. Mahmood. “GASTROPROTECTIVE POTENTIAL OF LASIA SPINOSA IN ALBINO RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 3, Mar. 2015, pp. 254-7, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/4365.

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