LAUQ KHAYAR SHAMBAR: A POLYHERBAL UNANI FORMULATION FOR THE MANAGEMENT OF COUGH
DOI:
https://doi.org/10.22159/ijpps.2022v14i5.43961Keywords:
Antitussive, Lauq, Munaffis-ī-balgham, Expectorant, Unani medicineAbstract
Cough is a physiological reflex, experienced by every human, is an important protective and defensive mechanism whose action secures the removal of foreign materials and secretions from the airways (larynx, trachea and bronchi). In various circumstances, such as respiratory tract inflammation, viral infections, allergic rhinitis, or inhalation of various irritants, it is unintentionally stimulated and a cough suppressant may be needed to relieve the cough. The currently available cough suppressants (opiates, dextromethorphan, etc.) limit their use in humans due to significant side effects such as constipation, respiratory depression, drowsiness. Lauq Khayar Shambar (LKS) is used as an antitussive in Unani medicine for centuries and is also used to treat various upper respiratory tract ailments such as asthma, dyspnoea, catarrh, productive and dry cough, pharyngitis and laryngitis. So, this review aims to explore the role of LKS in the management of cough.
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Chung KF. The Clinical and Pathophysiological Challenge of Cough. In: Cough: Causes, Mechanisms and Therapy [Internet]. Malden, Massachusetts, USA: Blackwell Publishing Ltd; 2008. p. 1–10. Available from: http://doi.wiley.com/10.1002/ 9780470755846.ch1. [Last accessed on 30 Mar 2022]
Kuang Y, Li B, Fan J, Qiao X, Ye M. Antitussive and expectorant activities of licorice and its major compounds. Bioorg Med Chem. 2018;26(1):278-84. doi: 10.1016/j.bmc.2017.11.046, PMID 29224994.
Saraswathy GR, Sathiya R, Anbu J, Maheswari E. Antitussive medicinal herbs-an update review. Int J Pharm Sci Drug Res. 2014;6(1):12-9.
Meher A. Antitussive evaluation of formulated polyherbal cough syrup. J Drug Delivery Ther. 2012;2(5):61-4. doi: 10.22270/jddt.v2i5.238.
Irwin RS, Rosen MJ, Braman SS. Cough. A comprehensive review. Arch Intern Med. 1977 Sep 1;137(9):1186-91. doi: 10.1001/archinte.137.9.1186, PMID 901087.
Ziment I. Herbal antitussives. Pulm Pharmacol Ther. 2002;15(3):327-33. doi: 10.1006/pupt.2002.0343, PMID 12099787.
Jahan Y, Mahmood T, Bagga P, Kumar A, Singh K, Mujahid M. Future prospects of cough treatment; Herbal medicines v/s modern drugs. Int J Pharm Sci Res. 2015;6(9):3689-97.
Gairola S, Gupta V, Bansal P, Singh R, Maithani M. Herbal antitussives and expectorants-a review. Int J Pharm Sci Rev Res. 2010;5(2):5-9.
Karegar Borzi H, Salehi M, Rahimi R. Lauq: a sustained-release dosage form for respiratory disorders in traditional persian medicine. J Evid Based Complementary Altern Med. 2016;21(1):63-70. doi: 10.1177/2156587215587417. PMID 26008751.
Anonymous. National Formulary of Una ni Medicine part 1. First. New Delhi (India): Central Council for research in Una ni Medicine. Ministry of Health and Family Welfare, Government of India; 2006. p. 1-337.
Anonymous. Physicochemical standards of Una ni formulation, Part 2. New Delhi (India): Central Council for research in Una ni Medicine. Ministry of Health and Family Welfare, Government of India; 1987.
Qarabadeen-e-Qadri AA. Urdu translation by CCRUM. New Delhi (India): Central council for research in Una ni Medicine. Ministry of Health and Family Welfare, Government of India; 2009.
Anonymous, Majeedi Q. New Delhi (India): (waqf Hamdard) all India Una ni Tibbi conference. 9th ed; 1986.
Al-Qarabadeen KM. New Delhi (India): Central Council for research in Una ni Medicine. Ministry of Health and Family Welfare, Government of India; 2006.
Muheet-e-Azam KA. New Delhi (India): Central Council for research in Una ni Medicine. Vol. 3. Ministry of Health and Family Welfare, Government of India; 2014.
Ghani N. Khazain al-Advia Vol. I and IV. Khazainul Advia. New Delhi: Idara Kitab al Shifa; 2011. p. 1–1260.
Makhzanul Mufradat KM. New Delhi: Aijaz Publication; 2014. p. 392.
Khan A. Muheet-i Azam. Vol 1. New Delhi (India): Central Council for research in Una ni Medicine. Ministry of Health and Family Welfare, Government of India; 2011.
Khazainul GM, Advia (Urdu). New Delhi, India: Idara Kitab al Shifa; 2011.
Al-Razi Z, Abdal KAl. Third edit. New Delhi (India): Central Council for research in Una ni Medicine. Ministry of Health and Family Welfare, Government of India; 2000.
Khan A. Muheet-e-Azam vol-2. New Delhi (India): Central Council for research in Una ni Medicine. Ministry of Health and Family Welfare, Government of India; 2013.
Mufradat Azizi HA. New Delhi (India): Central Council for research in Una ni Medicine. Ministry of Health and Family Welfare, Government of India; 2009.
Khan A, Muhit Azam. Vol 4. (Urdu Translation: CCRUM) [internet]. Ministry of Health and Family Welfare, Government of India; 2018. p. 1. Available from: http://ccrum.res.in. [Last accessed on 30 Mar 2022].
Maghrabi AS. Kitab al Fatah fi al tawdi (Urdu). 1st editio. New Delhi, India: Jamia Hamdard (Hamdard University); 2007.
Jasiem TM, Al-Mugdadi SFH, Aljubory IS, Latef QN. Phytochemical study and antibacterial activity of crude alkaloids and mucilage of cordia myxa in Iraq. Int J Pharm Sci Rev Res. 2016;39(1):232-6.
Al-Snafi PDAE. The pharmacological and therapeutic importance of Cordia myxa-a review. IOSR J Pharm. 2017;7(3):72-91.
Hojjati M, Beirami Serizkani F. Structural characterization, antioxidant and antibacterial activities of a novel water-soluble polysaccharide from Cordia myxa fruits. Food Measure. 2020 Dec 1;14(6):3417-25. doi: 10.1007/s11694-020-00586-y.
Salimimoghadam S, Ashrafi A, Kianidehkordi F, Najafzadehvarzi H. Hypoglycemic, antitussive and analgesic effects of nanoparticles of cordia myxa fruits extract. Int J Pharm Investig. 2019;9(4):205-9. doi: 10.5530/ijpi.2019.4.38.
AlBayaty MAA. Mechanism of the tracheal smooth muscle relaxant activity of the cordia myxa plant extract in sheep. Iraqi J Vet Med. 2008;32(2):214-26. doi: 10.30539/iraqijvm.v32i2.755.
Abdel-Aleem ER, Attia EZ, Farag FF, Samy MN, Desoukey SY. Total phenolic and flavonoid contents and antioxidant, anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Cordia myxa L. Leaves. Clin Phytosci. 2019 Dec 9;5(1):29. doi: 10.1186/s40816-019-0125-z.
Rashid Ali W, Al-Asady ZT, Ibrahim AJ. Immunomodulatory of cordia myxa (L.) aqueous extract fruit in immunized mice with hydatid cyst fluid. J Nat Sci Res. 2015;5(10).
Saki J, Khademvatan S, Pazyar N, Eskandari A, Tamoradi A, Nazari P. In vitro activity of cordia myxa mucilage extract against leishmania major and l. infantum promastigotes. Jundishapur J Microbiol. 2015 Mar 21;8(3):e19640. doi: 10.5812/jjm.19640, PMID 25861436
Fenwick GR, Lutomski J, Nieman C. Liquorice, glycyrrhiza glabra L.—composition, uses and analysis. Food Chem. 1990 Jan;38(2):119-43. doi: 10.1016/0308-8146(90)90159-2.
Farag MA, Porzel A, Wessjohann LA. Comparative metabolite profiling and fingerprinting of medicinal licorice roots using a multiplex approach of GC–MS, LC–MS and 1D NMR techniques. Phytochemistry. 2012 Apr;76:60-72. doi: 10.1016/j.phytochem.2011.12.010, PMID 22336263.
Li G, Nikolic D, van Breemen RB. Identification and chemical standardization of licorice raw materials and dietary supplements using UHPLC-MS/MS. J Agric Food Chem. 2016 Oct 26;64(42):8062-70. doi: 10.1021/acs.jafc.6b02954, PMID 27696846.
Mitra Mazumder P, Pattnayak S, Parvani H, Sasmal D, Rathinavelusamy P. Evaluation of immunomodulatory activity of glycyrhiza glabra L roots in combination with zing. Asian Pac J Trop Biomed. 2012 Jan;2(1):S15-20. doi: 10.1016/S2221-1691(12)60122-1.
Saha S, NosAlova G, Ghosh D, Fleskova D, Capek P, Ray B. Structural features and in vivo antitussive activity of the water extracted polymer from glycyrrhiza glabra. Int J Biol Macromol. 2011;48(4):634-8. doi: 10.1016/j.ijbiomac.2011.02.003, PMID 21329720.
Siracusa L, Saija A, Cristani M, Cimino F, D’Arrigo M, Trombetta D. Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves — chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity. Fitoterapia. 2011 Jun;82(4):546-56. doi: 10.1016/j.fitote.2011.01.009, PMID 21281704.
Maione F, Minosi P, Di Giannuario A, Raucci F, Chini MG, De Vita S. Long-lasting anti-inflammatory and antinociceptive effects of acute ammonium Glycyrrhizinate administration: pharmacological, biochemical, and docking studies. Molecules. 2019 Jul 4;24(13):2453. doi: 10.3390/molecules24132453, PMID 31277398.
Jalilzadeh Amin G, Najarnezhad V, Anassori E, Mostafavi M, Keshipour H. Antiulcer properties of glycyrrhiza glabra L. extract on experimental models of gastric ulcer in mice. Iran J Pharm Res. 2015;14(4):1163-70. PMID 26664383.
Tohma HS, Gulçin I. Antioxidant and radical scavenging activity of aerial parts and roots of Turkish liquorice (Glycyrrhiza glabra L.). Int J Food Prop. 2010 Jun 30;13(4):657-71. doi: /full/10.1080/10942911003773916.
Ashfaq UA, Masoud MS, Nawaz Z, Riazuddin S. Glycyrrhizin as an antiviral agent against hepatitis C virus. J Transl Med. 2011 Dec 18;9(1):112. doi: 10.1186/1479-5876-9-112, PMID 21762538.
Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK. Antimicrobial potential of glycyrrhiza glabra roots. J Ethnopharmacol. 2008 Mar;116(2):377-80. doi: 10.1016/j.jep.2007.11.037, PMID 18182260.
Sharma A, Kumar A, Jaitak V. Pharmacological and chemical potential of Cassia fistula L-a critical review. J Herb Med. 2021 Apr 1;26. doi: 10.1016/j.hermed.2020.100407, PMID 100407.
Rahmani AH. Cassia fistula Linn: potential candidate in the health management. Pharmacogn Res. 2015;7(3):217-24. doi: 10.4103/0974-8490.157956, PMID 26130932.
Barthakur NN, Arnold NP, Alli I. The Indian laburnum (Cassia fistula L.) fruit: an analysis of its chemical constituents. Plant Foods Hum Nutr. 1995 Jan;47(1):55-62. doi: 10.1007/ BF01088167, PMID 7784398.
Kaur S, Kumar A, Thakur S, Kumar K, Sharma R, Sharma A. Antioxidant, antiproliferative and apoptosis-inducing efficacy of fractions from cassia fistula L. Leaves. Antioxidants (Basel). 2020 Feb 20;9(2):173. Available from: https://www.mdpi.com/2076-3921/9/2/173. doi: 10.3390/antiox9020173, PMID 32093300.
Singh I, Gupta S, Gautam HK, Dhawan G, Kumar P. Antimicrobial, radical scavenging, and dye degradation potential of nontoxic biogenic silver nanoparticles using cassia fistula pods. Chem Pap. 2021 Mar 22;75(3):979-91. doi: 10.1007/s11696-020-01355-3.
Jyoti K, Arora D, Fekete G, Lendvai L, Dogossy G, Singh T. Antibacterial and anti-inflammatory activities of cassia fistula fungal broth-capped silver nanoparticles. Materials Technology. 2021;36(14):883-93. doi: 10.1080/10667857.2020.1802841.
Farooq H, Piracha MI, Usman M, Tariq R, Alam SS. Radiological analysis of hind paw joint in murine rheumatoid arthritis model treated prophylactically or therapeutically with cassia fistula versus naproxen. Proceedings. Proceedings of the Shaikh Zayed Med Complex Lahore. 2020 Nov 11;34(4):58-63. doi: 10.47489/p000s344z772mc.org.pk/index.php/szmc/article/view/11/11.
Laxmi V. Investigating the immunomodulatory effect of cassia fistula on albino rats. Adv Pharm Ethnomedicines. 2015;3(1):1-5. doi: 10.14737/journal.ape/2015/3.1.1.5.
AS, M LR, NS. Quantification of primary and secondary metabolites from leaves and stem bark of cochlospermum religiosum (l) alston. Int Res J Pharm. 2013 Sep 9;4(8):228-31. Available from: doi: 10.7897/2230-8407.04845/php/uploads/1969_pdf.
Ojha AK, Maiti D, Chandra K, Mondal S, Das Sadhan K, Roy DDSK, Ghosh K. Structural assignment of a heteropolysaccharide isolated from the gum of Cochlospermum religiosum (Katira gum). Carbohydr Res. 2008 May;343(7):1222-31. doi: 10.1016/j.carres.2008.03.010, PMID 18374321.
Bernela M, Ahuja M, Thakur R. Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles. Carbohydr Polym. 2016 Jun;143:18-24. doi: 10.1016/j.carbpol.2016.01.055, PMID 27083339.
Maity S, Kumar Sen I, Sirajul Islam SS. Green synthesis of gold nanoparticles using gum polysaccharide of cochlospermum religiosum (katira gum) and study of catalytic activity. Physica E: Low-dimensional Systems and Nanostructures. 2012 Aug;45:130-4. doi: 10.1016/j.physe.2012.07.020.
Mahendra C, Murali M, Manasa G, Ponnamma P, Abhilash MR, Lakshmeesha TR. Antibacterial and antimitotic potential of bio-fabricated zinc oxide nanoparticles of cochlospermum religiosum (L.). Microb Pathog. 2017 Sep;110:620-9. doi: 10.1016/j.micpath.2017.07.051, PMID 28778822.
Ponnamma P, Manasa G, Sudarshana MS, Murali M, Mahendra C. In vitro antioxidant, antibacterial and phytochemical screening of cochlospermum religiosum (L.) alston- A potent medicinal plant. Trop Plant Res. 2017 Jan 31;4(1):13-9. Available from: doi: 10.22271/tpr.2017.v4.i1.003/archives/2017/vol4issue1/3.pdf.
Al-Jawad F, Al-Razzuqi R, Hashim H, Al-Bayati N. Glycyrrhiza glabra versus Boswellia carterii in chronic bronchial asthma: A comparative study of efficacy. Indian J Allergy Asthma Immunol. 2012;26(1):6. doi: 10.4103/0972-6691.104437.
Jahan Y, Siddiqui HH. Study of antitussive potential of glycyrrhiza glabra and adhatoda vasica using a cough model induced by sulphur dioxide gas in mice. Int J Pharm Sci Res. 2012;3(6):1668-74.
Bhakta T, Mukherjee PK, Saha K, Pal M, Saha BP. Studies on the antitussive activity of Cassia fistula (Leguminosae) leaf extract. Pharm Biol. 1998;36(2):140-3. doi: 10.1076/ phbi.36.2.140.4598.
Abdallah IZA, Khattaba HAH, Heebab GH. Gastroprotective effect of cordia Myxa L. Fruit extracts against indomethacin-induced gastric ulceration in rats. Life Sci J. 2011;8(3):433-45.
Gupta GK, Tejas Joshi, Keshu Madhudiya, Arijit Chaudhuri. Therapeutic properties and nutritive values of some fruit bearing medicinal plants of rajasthan State in India. Pharmaceutical and Biosciences Journal. 2017;5(5):18. doi: 10.20510/ukjpb/5/i5/166552.
Ma C, Ma Z, Liao XL, Liu J, Fu Q, Ma S. Immunoregulatory effects of glycyrrhizic acid exerts anti-asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4(+)CD25(+)Foxp3+ regulatory T cells in ovalbumin-sensitized mice. J Ethnopharmacol. 2013;148(3):755-62. doi: 10.1016/j.jep.2013.04.021, PMID 23632310.
Ram A, Mabalirajan U, Das M, Bhattacharya I, Dinda AK, Gangal SV, Ghosh B. Glycyrrhizin alleviates experimental allergic asthma in mice. Int Immunopharmacol. 2006;6(9):1468-77. doi: 10.1016/j.intimp.2006.04.020, PMID 16846841.
Hocaoglu AB, Karaman O, Erge DO, Erbil G, Yilmaz O, Bagriyanik A, Uzuner N. Glycyrrhizin and long-term histopathologic changes in a murine model of asthma. Curr Ther Res Clin Exp. 2011 Dec 1;72(6):250-61. doi: 10.1016/j.curtheres.2011.11.002, PMID 24648593.
Shin YW, Bae EA, Lee B, Lee SH, Kim JA, Kim YS. In vitro and in vivo antiallergic effects of glycyrrhiza glabra and its components. Planta Med. 2007 Mar;73(3):257-61. doi: 10.1055/s-2007-967126, PMID 17327992.
Ikseer Azam KA. Urdu translation by Kabeeruddin. New Delhi, India: Idara Kitabus Shifa; 2011.
Sina I. Al-Qanun Fit-Tibb. Vol. I-V (Urdu translation by Ghulam husain Kantoori). New Delhi, India: Idara Kitabu-us-Shifa; 2007. p. 1-960.
Kulliyat-e-Nafeesi NB (Urdu translation by Kabeeruddin). 1st ed. New Delhi, India: Idara Kitabus Shifa; 1954. p. 1-528.
Kulliyat-e-Qanoon SI (Urdu translation by Kabiruddin). 2nd ed. New Delhi, India: Idara Kitabus Shifa; 2015. p. 1-383.
Kitab Al-Kulliyat RI (Urdu). Lahore: Maktaba Daniyal; 1987. p. 1-456.
Majoosi A bin A. Kamil-us-sana (Urdu translation by Hkm. Ghulam Hussain Kantoori. New Delhi, India: Idara Kitab-us-Shifa; 2010. p. 1-820.
Firdous Al-Hikmat TA. (Urdu translation by Hakeem Muhammad Shah). 2nd ed. New Delhi, India: Idara Kitabus Shifa; 2017. p. 1-484.
Kitab al Hawi Razi Z. New Delhi, India: CCRUM; 2004.
Khan MS, Khas BE. Urdu translation. New Delhi, India: Ejaz publishing house; 2006.
Bayaz-e-Kabeer KM. New Delhi: Idara Kitabu-us-Shifa-Part II; 2010.
Sherazi MMBK. Qarabadeen-e-masoomi. New Delhi (India): national mission for manuscripts; 2017.
Qarabadeen-e-Qadri AA. New Delhi: (Urdu translation) CCRUM, Govt. of India. Ministry of Health and F.W. Department of AYUSH; 2009. p. 26-7.
Ghani HN. Qarabadeen-e-najmul ghani. New Delhi, India: CCRUM; 2010.
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