ENVIRONMENTALLY BENIGN SYNTHESIS OF N'-SUBSTITUTED NAPHTHALENE-1-SULFONOHYDRAZIDE UNDER MICROWAVE IRRADIATION AND THEIR BIOLOGICAL EVALUATION

Authors

  • Sunita Ghiya 207, Deptt. of Chemistry, University of Rajasthan, Jaipur. Pin no. 302004
  • Yogesh C Joshi 207, Deptt. of Chemistry, University of Rajasthan, Jaipur. Pin no. 302004

Keywords:

Hydrazones, Condensation, Microwave irradiation, Antimicrobial activity

Abstract

Objective: Microwave synthesis provides an alternative environmentally benign method with excellent yield and shorter reaction time. The aim of this study is to synthesize some new sulfonohydrazide derivatives by conventional/microwave method and their antimicrobial evaluation.

Methods: Condensation of naphthalene-1-sulfonohydrazide with aromatic carbonyls under Conventional refluxing/microwave irradiation.

Results: A facile, rapid and eco-friendly synthetic route for the synthesis of new sulfonohydrazide derivatives by microwave irradiation method was reported. Structures of the newly synthesized compounds were elucidated by elemental analysis and spectral studies viz. IR, NMR and MS. These compounds showed good to excellent antimicrobial activity against tested microbial strains.  The zone of inhibition and minimum inhibitory concentration values for tested microbial strains was in range of 10-14 mm and 6.25-25μg/ml.

Conclusion: A novel series of biologically active N′-substituted naphthalene-1-sulfonohydrazide derivatives were synthesized by green method. Most of the newly synthesized compounds showed good to excellent antimicrobial activity.

 

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Published

01-03-2015

How to Cite

Ghiya, S., and Y. C. Joshi. “ENVIRONMENTALLY BENIGN SYNTHESIS OF N’-SUBSTITUTED NAPHTHALENE-1-SULFONOHYDRAZIDE UNDER MICROWAVE IRRADIATION AND THEIR BIOLOGICAL EVALUATION”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 3, Mar. 2015, pp. 249-53, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/4474.

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