STUDY OF PHYSICAL INTERACTION BETWEEN IBUPROFEN AND CAFFEINE AND ITS INFLUENCE ON SOLUBILITY AND HYGROSCOPICITY OF IBUPROFEN

Authors

  • Ilma Nugrahani School of Pharmacy Institute Technology Bandung, Lab Tech VII ITB, Ganesha 10, Bandung 40132, Indonesia
  • Kathelea Aulia Kartini School of Pharmacy Institute Technology Bandung, Lab Tech VII ITB

Keywords:

Ibuprofen, Caffeine, Eutectic, Solubility, Hygroscopicity

Abstract

Objective: Physical interaction between two or more pharmaceutical substance linkaged by hydrogen bonding can improve the physicochemical properties. This research investigated ibuprofen–caffeine physical interaction that never investigated. The research followed by observed the interaction influence towards ibuprofen solubility and hygroscopicity.

Methods: Ibuprofen, caffeine, and a series mixture of ibuprofen-caffeine; before and after neat grinding was characterized with Fourier-Transform Infrared Spectroscopy (FTIR), Differential Thermal Analysis (DTA), Powder X-ray Diffraction (PXRD). Solubility in water was examined by UV VIS Spectrophotometer. Hygroscopicity test was done by stored the physical interaction mixture in the extreme humidity (99% RH); next the water content was determined by Karl Fisher titration.

Results: FTIR spectra C=O stretching showed a little shifting after a neat grinding. DTA thermograms showed the lower melting point compared its components. Diagram phase of the binary system showed first the lowest temperature at 73.7 °C of ratio 1:9 and 145 °C of ratio 8:2. However, diffractogram of ground mixture didn't show any new spectrum, indicated no new crystal phase arranged. Last, solubility and hygroscopicity showed that the physical interaction had the higher value on both parameters compared to each compounds.

Conclusion: Ibuprofen–caffeine indicated to form the physical interaction, which has lower melting point without new crystal phase formation, that is cathegorized as an eutectics interaction. Nevertheless, this eutectic mixture causes the increasing of ibuprofen solubility and hygroscopicity.

 

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References

Carstensen JT. Pharmaceutical Principles of Solid Dosage Forms. Lancaster PA: Technomic Publishing; 1993.

Carstensen JT. Advanced Pharmaceutical Solids. New York: Taylor and Francis; 2001. p. 175–6.

Qiu Y, Chen Y, Zhang GGZ, Liu L, Porter W. Developing solid oral dosage forms: Pharmaceutical Theory and Practice. 1st ed. New York: Elsevier; 2009.

Bharate SS, Bharate BS, Bajaj AN. Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients: a comprehensive review. J Excipients Food Chem 2010;1:3–26.

Britainn HG. Polymorphism in pharmaceutical solids. New York: Marcel Decker Inc; 2009.

http://www.drugbank.ca/drugs/DB01050, Ibuprofen Structure. [Last accessed on 01 Jun 2014]

http://www.drugbank.ca/drugs/DB02701, Nicotinamide Structure. [Last accessed on 01 Jun 2014]

Matkovic SR, Valle GM, Briand LE. Quantitative analysis of ibuprofen in pharmaceutical formulation through FTIR spectroscopy. Lat Am Appl Res 2005;35:189–95.

Soares FLF, Carneiro RL. Green synthesis of ibuprofen−nicotinamide co-crystals and in-line evaluation by raman spectroscopy. Cryst Growth Des 2013;13:1510–7.

Chow SF, Chen M, Shi L, Chow AH, Sun CC. Simultaneously improving the mechanical properties, dissolution performance, and hygroscopicity of ibuprofen and flurbiprofen by co-crystallization with nicotinamide. Pharm Res 2012;29:1854–65.

Berry DJ. Applying hot-stage microscopy to co-crystal screening: a study of nicotinamide with seven active pharmaceutical ingredients. Cryst Growth Des 2008;8:1697–712.

Jayasankar A. Understanding The Mechanism, Thermodynamics, and Kinetics of Co-crystallization to control phase transformations. Dissertation. The University of Michigan; 2008.

Schultheiss N, Newman A. Pharmaceutical co-crystals and their physicochemical properties. Crys Growth Des 2009;9:2950–67.

Kumar GS, Seethalakshmi PG, Sumathi D, Bhuvanesh N, Kumaresan S. Syntheses, structural characterization, and DPPH radical scavenging activity of co-crystals of caffeine with 1-and 2-naphthoxyacetic acids. J Mol Struct 2013;1035:476–82.

Aitipamula S. Polymorphs, salts, and co-crystals: What’s in a name? Cryst Growth Des 2012;12:2147−52.

Sekhon BS. Pharmaceutical co-crystals-a review. Ars Pharm 2009;50:99–117.

Qiao N, Li M, Schlindwein W, Malek N, Davies A, Trappitt G. Pharmaceutical co-crystals: an overview. Int J Pharm 2011;419:1–11.

Hapse SA, Kadaskar PT, Shirsath AS. Difference spectrophotometric estimation and validation of ibuprofen from bulk and tablet dosage form. Der Pharm Lett 2011;3:18–23.

Liua D, Feib X, Wanga S, Tongying J, Sua D. Increasing solubility and dissolution rate of drugs via eutectic mixtures: itraconazole–poloxamer188 system. Asian J Pharm Sci 2006;1:213–21.

Cherukuvada S, Nangia A. Eutectics as improved pharmaceutical materials: design, properties and characterization. Chem Commun 2014;50:906–23.

Published

01-11-2015

How to Cite

Nugrahani, I., and K. A. Kartini. “STUDY OF PHYSICAL INTERACTION BETWEEN IBUPROFEN AND CAFFEINE AND ITS INFLUENCE ON SOLUBILITY AND HYGROSCOPICITY OF IBUPROFEN”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 11, Nov. 2015, pp. 223-7, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/4644.

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Original Article(s)