EVALUATION OF SKELETAL MUSCLE RELAXANT ACTIVITY OF AQUEOUS EXTRACT OF CINNAMOMUM VERUM BARK ON SWISS ALBINO MOUSE

ANAMIKA HAZARIKA; PALLAVI BORDOLOI; GEETAMONI DUTTA; DIPJYOTI DEKA

doi:10.22159/ijpps.2024v16i8.51408

Authors

ANAMIKA HAZARIKA Department of Pharmacology, Jorhat Medical College and Hospital, Assam, India https://orcid.org/0009-0002-0377-4127
PALLAVI BORDOLOI Department of Pharmacology, Tinsukia Medical College and Hospital, Assam, India https://orcid.org/0009-0009-4534-5487
GEETAMONI DUTTA Department of Pharmacology, Jorhat Medical College and Hospital, Assam, India https://orcid.org/0000-0001-7155-3241
DIPJYOTI DEKA Department of Pharmacology, Jorhat Medical College and Hospital, Assam, India

DOI:

https://doi.org/10.22159/ijpps.2024v16i8.51408

Keywords:

Cinnamomum verum, Cinnamomum zeylanicum, Ceylon cinnamon, Rota rod, Actophotometer, Muscle relaxant

Abstract

Objective: To evaluate the muscle relaxant activity of aqueous extract of bark of Cinnamomum verum (synonyms: Cinnamomum zeylanicum, Ceylon cinnamon) [AEBCV] on swiss albino mouse.

Methods: Twenty-two albino mice (25-30g) were taken and divided into four groups. The first group was kept as a control (Distilled water), second as the standard (Diazepam) and remaining two groups as test 1 and 2 were given different doses of AEBCV (50 and 100 mg/kg). Skeletal muscle relaxant activity on rotarod and actophotometer were performed. Statistical analysis was carried out by using ANOVA, followed by Tukey’s multiple comparison tests, using GraphPad Prism software. P-value<0.05 was considered significant.

Results: In rotarod test, AEBCV (50 mg/kg, 100 mg/kg) significantly reduced motor coordination of tested animals when compared to control (P<0.05). Maximum muscle relaxation was observed with 100 mg/kg. In actophotometer, AEBCV showed highly significant reduction (P<0.05) in the locomotor activity when compared to control that, is 74% and 81%. AEBCV also showed a significant reduction when compared to standard.

Conclusions: Our data indicates that AEBCV possesses skeletal muscle relaxant activities.

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