ETHANOL ROOT EXTRACT OF THE AFRICAN APHRODISIAC, MONDIA WHITIE (PERIPLOCACEAE), POSSESES ESTROGENIC ACTIVITY
Keywords:
Mondia whittie, Estrous cycle, Uterotrophic, Female reproductionAbstract
Objective: To determine the effects of ethanol extract of the dried root Mondia whitie (mondia) on female reproductive system using the chick uterotrophic assay and the rodent estrous cycle studies.
Methods: Phytochemical screening was done to detect the presence of secondary metabolites. Using the Chick Oviduct Uterotrophic assay, estrous cyclicity assay in Sprague Dawley rats and serum biochemical analysis, the effects of ethanol root extract of mondia on female reproduction was assessed.
Results: Mondia (30-300) mg/kg or estradiol benzoate (0.1-0.8 ug/kg) caused dose dependent increases in chick oviduct of white leghorns. Treatment of rats with Mondia (30-300) mg/kg increased duration of estrous and altered the repeatability of the next cycles. The estrus index ranged between 41.67-49.21 at the doses of mondia used compared with 25 for controls. There were alterations in the lipid profile with reductions in HDL, but increases in VLDL, LDL and triglycerides.
Conclusion: Ethanol extract of the dried root Mondia whitie possess estrogen-like activity on the female reproductive system
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