SOLUBILITY ENHANCEMENT OF LURASIDONE HYDROCHLORIDE BY PREPARING SMEDDS

Authors

  • Foram Jangipuria Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, NMIMS, Vile Parle-W, Mumbai 400056, Maharashtra, India
  • Vaishali Londhe Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, NMIMS

Keywords:

Lurasidone Hydrochloride, Solubility enhancement, SMEDDS, In-vitro dissolution, Ex-vivo diffusion

Abstract

Objective: The objective of the study was to enhance solubility of Lurasidone HCl, an atypical antipsychotic drug, by formulating self-micro emulsifying drug delivery system (SMEDDS) and its characterization.

Methods: Solubility study of Lurasidone hydrochloride (LH) was carried out in various surfactants, co surfactants and oils. Pseudo ternary phase diagrams were constructed to identify the self-micro emulsification region. Screening was done so as to determine the proper combination of components. Based on this, LH SMEDDS were prepared using Cremophor RH40 (surfactant), Soluphor P (co-surfactant) and Capmul MCM (oil). The preconcentrate SMEDDS were evaluated for clarity(visual), precipitation, % transmittance, robustness to dilution, freeze thawing, particle size distribution and zeta potential and adsorbed SMEDDS were evaluated for drug content, flow properties, in-vitro dissolution and ex-vivo diffusion studies.

Results: The optimized LH SMEDDS composed of 14% Cremophor RH40, 68% Soluphor P, 18% Capmul MCM with a particle size of 3.95 µm and zeta potential of more than 50 mV showing 80% dissolution in 60 min.

Conclusion: The results of this study prove that SMEDDS help in improving the solubility, dissolution and bioavailability of lurasidone hydrochloride.

 

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Published

01-11-2015

How to Cite

Jangipuria, F., and V. Londhe. “SOLUBILITY ENHANCEMENT OF LURASIDONE HYDROCHLORIDE BY PREPARING SMEDDS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 11, Nov. 2015, pp. 283-8, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/6501.

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