ASSESSMENT OF THE TABLETING CHARACTERISTICS OF A NOVEL SORBITOL AND CALCIUM DIPHOSPHATE COMPOSITES
Keywords:
Sorbitol, Calcium diphosphate, Composites, Tableting, Direct compressionAbstract
Objective: To improve the tableting properties of sorbitol (SOR) via particle engineering through agglomeration with anhydrous calcium diphosphate (ACD) employing a house-made agglomerator.
Methods: A novel SOR: ACD composites were produced by agglomeration at the 95:5; 80:20, 50:50, 20:80 and 6:94 SOR to ACD. The resulting tableting properties such as densification, compressibility, compactibility, ejection force, elastic recovery, sensitivity to lubricants, compression speed and disintegration time were then evaluated.
Results: The new agglomerated excipient had better flow, compressibility and compactibility than the physical mixture of SOR and ACD being the 95:5 SOR: ACD ratio the composite that exhibited the best tableting properties.
Conclusion: This novel excipient has a potential use as a pharmaceutical aid for direct compression applications.
Â
Downloads
References
Ramya K, Chowdary K. Preparation, characterization and evaluation of a new coprocessed excipient as directly compressible vehicle in tablet formulation. J Global Trends Pharm Sci 2013;4:1322-8.
Guyot-Herman A, Draguet-Brughmans M. Gama sorbitol as a diluent in tablets. Drug Dev Ind Pharm 1985;11:551-64.
Reiff F, Hartner H, Basedow A, Hugenbush HW, Schmidt PC, Bardonner H. Sorbitol, process for its preparation and use there of; 1986. p. 794.
Lachman L, Lieberman HA, Kanig J. The Theory and Practice of Industrial Pharmacy. (Febiger, L. ed). 3rd ed. Philadelphia; 1986. p. 1317-8.
Doldan C, Souto C, Concheiro A, Martinez-Pacheco R, Gomez-Amoza J. Dicalcium phosphate dihydrate and anhydrous dicalcium phosphate for direct compression: a comparative study. Int J Pharm 1995;124:69-74.
Saha S, Shahiwala AF. Multifuncional coprocessed excipients for improved tableltting performance. Expert Opin Drug Delivery 2009;6:197-208.
Bolhuis CK, Chowham ZT. Pharmaceutical Powder Compaction Technology (Alderborn G. Nystrom, C. eds.) New York, Marcel Dekker; 1996.
Echeverri E, Rojas J. Functionality enhancement of sorbitol and anhydrous calcium diphosphate composites for direct compression applications. Int J Res Pharm Sci 2014;5:299-303.
Rojas J, Ciro Y, Correa L. Functionality of chitin as a direct compression excipient: An acetaminophen comparative study. Carbohyd Polym 2014;103:134-9.
Paronem P, Ilkka J. Pharmaceutical Powder Compaction Technology. (Alderborn G, Nystrom C. eds.). Marcel Dekker, New York; 1996.
Heckel RW. Density-pressure relationships in powder compaction. Trans Metall Soc AIME 1961a;221:671-5.
Heckel RW. An analysis of powder compaction phenomena. Trans Metall Soc AIME 1961b;221:1001-8.
Jetzwer W, Leuenberger H, Sucker H. The compressibility and compactibility of pharmaceutical powders. Pharm Technol 1983;74:33-9.
Leuenberger H, Rohera BD. Fundamentals of powder compression 1. The compactibility and compressibility of Pharmaceutical powders. Pharm Res 1986;3:12-22.
Armstrong NA, Haines-Nutt RF. Elastic recovery and surface area changes in compacted powder systems. J Pharm Pharmacol 1972;24:135-6.
Nezzal A, Aerts Luc, Verspaille M, Henderickx G, Redl A. Polymorphism of sorbitol. J Cryst Growth 2009;311:3863-70.
Willard JF, Lefebvre J, Danede F, Comini S, Looten P, Descamps M. Polymorphic transformation of Γ-form of D-sorbitol upon milling: structural and nanostructural analyses. Solid State Commun 2005;135:519-24.