ANTIDIABETIC ACTIVITY OF CLERODENDRUM PHILIPPINUM SCHAUER LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Keywords:
Clerodendrum philippinum Schauer, Antidiabetic activity, StreptozotocinAbstract
Objective: The present study has been undertaken to evaluate the antidiabetic activity of Clerodendrum philippinum Schauer leaves.
Methods: The fresh leaves were collected from Kuruan village of Jajpur district in the state of Odisha, India and extracted successively with n-hexane, methanol and water. The effect of extracts at the dose level of 400 mg/kg body weight was studied in normal, glucose loaded and streptozotocin-induced diabetic rats.
Results: The test extracts showed significant reduction of blood glucose level in normal, glucose loaded and streptozotocin-induced diabetic rats. Methanol extract demonstrated maximum blood glucose lowering potential as compared to other extracts.
Conclusion: The leaf of Clerodendrum philippinum Schauer is endowed with blood sugar lowering potential in both normal and diabetic rats.
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