UMBELLIFERONE EXTENUATES THE ABNORMALITIES IN LIPID METABOLISM DURING D-GALACTOSAMINE AND LIPOPOLYSACCHARIDE INDUCED FULMINANT HEPATIC FAILURE IN RATS.
Abstract
Objective: Coumarins and coumarin-related compounds are a plentiful source of potential drugs candidate in relation to its safety and efficacy. Hence, the present study was designed to evaluate the protective nature of Umbelliferone (UMB), a coumarin derivative on alterations in lipid metabolism during D-Galactosamine (D-GalN) and Lipopolysaccharides (LPS) induced Fulminant hepatic failure (FHF).
Methods: Male wistar rats were challenged with a single intraperitoneal injection of D-GalN/LPS, and the protective nature of UMB was examined with reference to Total Cholesterol, Phospholipids, Triglycerides, free fatty acids(plasma, liver, and kidney), lipid metabolizing enzymes and lipoprotein fraction.
Results: Anomalies in lipid status, lipid metabolizing enzymes and lipoprotein fractions induced by D-GalN/LPS was restored to near normal levels upon pretreatment with UMB which was further confirmed by Transmission electron microscopic observations.
Conclusion: The outcome of the above findings evidenced the protective nature of UMB on alterations in lipid metabolism during D-GalN/LPS induced FHF in rats.
Keywords: Umbelliferone, D-Galactosamine, Lipopolysaccharides (LPS), Lipid metabolism, Liver failure, Lipid metabolizing enzymes, Lipoproteins, Transmission electron microscope.
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