FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE IBUPROFEN TABLETS WITH ACRYLIC POLYMERS (EUDRAGIT) AND HPMC
Keywords:
Ibuprofen, Eudragit, HPMC, Sustained releaseAbstract
Objective: An attempt was made to develop sustained release matrix tablets of ibuprofen using HPMC (K4M, K15M & K100M) and eudragit (RS 100 & RL 100) as release retardant polymers.
Methods: The ibuprofen matrix tablets were prepared by direct compression method using lactose as a diluent. Nineteen formulations of different polymer percentages were formulated, (F1-F19 with 7.5%, 10%, 15%, 20%, 25%, 30% w/w).
Results: The formulations were optimized on the basis of acceptable weight variation, thickness, hardness, % friability, % drug content and in vitro drug release. The in vitro release studies were performed using USP type II apparatus using 7.2 pH phosphate buffer as a dissolution medium, showed that optimized formulation F8 consisting of eudragit RL with 20% of the polymer was found to sustain the release of ibuprofen over a period of 12 h. The formulation exhibited highest correlation (R) value in case of Hixson-Crowell model and the release kinetic study proved that the formulation showed erosion process, and shown to follow zero order kinetics.
Conclusion: It was concluded that eudragit RL can be used for the preparation of sustained release tablet of ibuprofen.
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References
Tapan KG, Amit A, Hemanth B. A novel and alternative approach to controlled release drug delivery system are based on solid dispersion technique. Bull Fac Pharm 2012;50:147-59.
Girish B, Ismail P, Gowda D. Formulation and evaluation of sustained release matrix tablets of flurbiprofen using guar gum. Int J Pharm Pharm Sci 2012;4 Suppl 5:120-3.
Oluwatoyin A, Okunlola A, Lamprecht A. Formulation and in vitro evaluation of natural gum based micro beads for delivery of ibuprofen. Trop J Pharm Res 2014;13:1577-83.
Hind Z, Khalil S, Fars K. Designing an extended release waxy matrix tablet containing nicardipine-hydroxy propyl ß cyclodextrin complex. Saudi Pharm J 2011;19:245-53.
Tripathi KD. Essentials of medical pharmacology. 6th ed. Jaypee Publishers, New Delhi; 1985. p. 173-210.
Ofokansi KC, Kenechukwu FC. Formulation development and evaluation of drug release kinetics from colon–targeted ibuprofen tablets based on eudragit RL 100-chitosan inter polyelectrolyte complexes. ISRN Pharm 2013;10:1-10.
Chandran S, Laila F, Asghar A, Neelima M. Design and evaluation of ethyl cellulose based matrix tablets of ibuprofen with pH modulated release kinetics. Indian J Pharm Sci 2003;20:596-602.
Rohini D, Alexandar S, Sekar C. Preparation and in vitro evaluation of sustained release tablet formulations of metformin HCl. Asian J Pharm Clin Res 2012;5:45-8.
Rahman A, Gamal M, Mahmoud E. Preparation and comparative evaluation of sustained release metoclopramide hydrochloride matrix tablets. Saudi Pharm J 2009;17:283-8.
Shah RB, Tawakkul MA, Khan MS. Comparative evaluation of flow for pharmaceutical powders and granules. AAPS PharmSciTech 2008;9:251-60.
Arunachalam A, Mazumde A. The outcome of formulation and in vitro release studies of levothyroxine sodium tablets. Asian J Pharm Sci Tech 2011;1:33-9.
Sarker A, Pathan A, Shrestha D, Kibria G, Jalil R. Investigation of in vitro release kinetics of carbamazepine from eudragit ® RS PO and RL PO matrix tablets. Trop J Pharm Res 2009;8:145-52.
United state pharmacopeia. The council of experts. Asian ed. The board of trustees publications, US pharmacopeia national formulary; 2004. p. 305.
Indian pharmacopoeia. Ministry of health and family welfare. 4th ed. Controller of publications, Govt. of India. New Delhi; 1996. p. 735.
Aulton EM. Pharmaceutics: Controlled release systems. The science of dosage form design. 2nd ed. living stone, Elsevier; 2007. p. 101-25.
Martin physical pharmacy and pharmaceutical sciences. (Sinko PJ eds). Physical-chemical and biopharmaceutical principles in the pharmaceutical sciences. 6th ed. Wolter Publishers, New Delhi; 2011. p. 138-50.
Raghuram K, Srinivas M, Srinivas R. Once-daily sustained release matrix tablets of Nicorandil: formulation and in vitro evaluation. AAPS PharmSciTech 2003;4:1-9.
Vyas SP, Paliwal SR, Paliwal R. The theory and practice of industrial pharmacy. (Lachman HA, Lieberman L, eds). Targeted drug delivery systems. 4th ed. CBS Publishers, New Delhi; 2013. p. 936-8.
Sanjay D, Bhaskar M, Sankha C, Das MK, Samarendu S, Ganguly S, et al. Polymers derived from xanthomonas competencies and retardant materials for the formulation of sustained release floating matrix tablet of atenolol. Int J Biol Macromol 2014;651:345-56.
Chithirra A, Mohamed S, Pillai k, Abirami A, Aruna A. Formulation and evaluation of controlled release frusemide tablets by bilayer technology. J Drug Delivery Res 2013;3:37-44.
Chime SA, Onunkwo GC, Onyishi II. Kinetics and mechanisms of drug release from swellable and nonswellable matrices: a review. Res J Pharm Biol Chem Sci 2013;4:97-104.