PHENYTOIN-INDUCED ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS

Authors

  • Navin Patil Dept of Pharmacology, Kasturba Medical College, Manipal
  • Sushil Kiran Kunder Dept of Pharmacology, Kasturba Medical College, Manipal
  • Avinash A Dept of Pharmacology, Kasturba Medical College, Manipal
  • Anurag Pathak Dept of Pharmacology, Kasturba Medical College, Manipal
  • Sharath Madhyastha Dept of Medicine, Kasturba Medical College, Manipal
  • Karthik Rao N Dept of Medicine, Kasturba Medical College, Manipal
  • Raghavendra Rao Dept of Medicine, Kasturba Medical College, Manipal

Abstract

ABSTRACT
Phenytoin is the first line antiepileptic for generalized tonic-clonic seizures. It is still the go to†drug despite the availability of newer antiepileptics,
chiefly
because of its low
cost and high
efficacy.
Phenytoin
is associated
with toxicities
involving
multiple organ
systems
such as

brain,
blood, and skin. One of the most common adverse
effects
is the development
of skin rashes.
It can range
from
mild to
life-threatening
skin

eruptions.
This is a case report
of a young
girl
who
developed
acute
generalized
exanthematous
pustulosis following
phenytoin
therapy
for
posttraumatic
seizures.
Keywords: Drug-induced rash, Anti-epileptic, Type-4 hypersensitivity, Hydantoin

Downloads

Download data is not yet available.

References

REFERENCES

Misra UK, Kalita J, Rathore C. Phenytoin and carbamazepine cross

reactivity: Report of a case and review of literature. Postgrad Med J

;79(938):703-4.

Leclair MA, Maynard B, St-Pierre C. Acute generalized exanthematous

pustulosis with severe organ dysfunction. CMAJ 2009;181(6-7):393-6.

Peermohamed S, Haber RM. Acute generalized exanthematous

pustulosis simulating toxic epidermal necrolysis: A case report and

review of the literature. Arch Dermatol 2011;147(6):697-701.

Criton S, Sofia B. Acute generalised exanthematous pustulosis. Indian

J Dermatol Venereol Leprol 2001;67(2):93-5.

Sidoroff A, Halevy S, Bavinck JN, Vaillant L, Roujeau JC. Acute

generalized exanthematous pustulosis (AGEP) - a clinical reaction

pattern. J Cutan Pathol 2001;28(3):113-9.

Published

01-03-2016

How to Cite

Patil, N., S. K. Kunder, A. A, A. Pathak, S. Madhyastha, K. Rao N, and R. Rao. “PHENYTOIN-INDUCED ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 2, Mar. 2016, pp. 10-11, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/10298.

Issue

Section

Case Study(s)

Most read articles by the same author(s)

<< < 1 2 3 4 > >>