PHENYTOIN-INDUCED ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS

Abstract

ABSTRACT
Phenytoin is the first line antiepileptic for generalized tonic-clonic seizures. It is still the go to†drug despite the availability of newer antiepileptics,
chiefly
because of its low
cost and high
efficacy.
Phenytoin
is associated
with toxicities
involving
multiple organ
systems
such as

brain,
blood, and skin. One of the most common adverse
effects
is the development
of skin rashes.
It can range
from
mild to
life-threatening
skin

eruptions.
This is a case report
of a young
girl
who
developed
acute
generalized
exanthematous
pustulosis following
phenytoin
therapy
for
posttraumatic
seizures.
Keywords: Drug-induced rash, Anti-epileptic, Type-4 hypersensitivity, Hydantoin