REVIEW ON ENHANCEMENT OF GLUCOSE UPTAKE AND UP-REGULATION OF GLUCOSE TRANSPORTERS BY ANTIDIABETIC MEDICINAL PLANTS
Abstract
ABSTRACT
Glucose is a key fuel in mammalian cells that import by a process of facilitative diffusion mediated by glucose transporters (GLUT). A defect in GLUT
expression for prolong time leads to diabetes mellitus. Medicinal plants used in traditional treatments confirm a possibility of tackling diabetes by
regulating the GLUT activity in the body, with lesser side effects. Resistant of tissues to insulin is a major manifestation in type 2, and the cause can be
localized in defect of glucose that can be reverse by medicinal plants. In vitro, in vivo, and in silico studies of plant extracts and its active compounds
support for their multiple target mechanisms. Many medicinal plants used in the traditional medicine enhancing the translocation of GLUT and this
could lead to a new approach for treating type 2 diabetes.
Keywords: Diabetes, Glucose transporters, Mechanism of glucose transporter, Glucose transporters 4, Medicinal plants.
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References
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Table 1: (Contd...)
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Tamarindus indica Aqueous seed extract Quantitative reverse transcription-PCR results showed increase in muscle GLUT4
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Pterocarpus marsupium Isoflvone Isoflavone of this plant exert the same glucose transport activity in an alternate
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Cornus kousa Results showed that increases the GLUT4 translocation through increased insulin
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Persea americana Hydroalcoholic extract The extract regulates glucose uptake in liver and muscles by the activation of
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Fermented tea extract It activates both PI3K/Akt- and MPK-dependent signaling pathways to induce
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Pine bark extract In vitro the results proved that the extract acts by activating p38 mitogen-activated
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Cecropia obtusifolia Aqueous extract Activates the insulin signaling pathway and translocate GLUTs [42]
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