CORRELATION STUDY OF SERUM CALCIUM LEVELS AND SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN LEVELS IN RHEUMATOID ARTHRITIS PATIENTS IN BANDUNG, INDONESIA

Authors

  • Nyi Mekar Saptarini Department of Pharmacochemistry, School of Pharmacy, Institut Teknologi Bandung, Jl Ganesha 10, West Java 40132, Indonesia.
  • Marlia Singgih Wibowo Department of Pharmacochemistry, School of Pharmacy, Institut Teknologi Bandung, Jl Ganesha 10, West Java 40132, Indonesia.
  • Tutus Gusdinar Department of Pharmacochemistry, School of Pharmacy, Institut Teknologi Bandung, Jl Ganesha 10, West Java 40132, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i11.18493

Keywords:

Autoimmune disease, Rheumatoid arthritis monitoring, Complexometric, Enzyme-linked immunosorbent assay, Indonesia

Abstract

 

 Objective: This study was designed is to determine the correlation between serum calcium level and serum cartilage oligomeric matrix protein (COMP) level in Indonesian patients with rheumatoid arthritis (RA).

Subjects and Methods: The subjects are patients who visit the rheumatology clinic at a government hospital in Bandung, Indonesia. Serum calcium level was determined by a complexometric method, and the serum COMP level was determined by enzyme-linked immunosorbent assay. Statistical analysis was performed with R software.

Results: The serum calcium level was 82.24±44.82 mg/mL in RA patients and 99.04±60.56 mg/mL in normal controls. The serum COMP level was 843.80±35.79 ng/ml in RA patients and 830.00±48.92 ng/ml in normal controls.

Conclusion: There is no correlation between serum calcium level and serum COMP levels in RA patients (p=0.967 and rho=0.006).

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Author Biographies

Nyi Mekar Saptarini, Department of Pharmacochemistry, School of Pharmacy, Institut Teknologi Bandung, Jl Ganesha 10, West Java 40132, Indonesia.

Department of Pharmacutical Analysis and Medicinal Chemistry, Faculty of Pharmacy

Marlia Singgih Wibowo, Department of Pharmacochemistry, School of Pharmacy, Institut Teknologi Bandung, Jl Ganesha 10, West Java 40132, Indonesia.

Department of Pharmacochemistry, Faculty of Pharmacy

Tutus Gusdinar, Department of Pharmacochemistry, School of Pharmacy, Institut Teknologi Bandung, Jl Ganesha 10, West Java 40132, Indonesia.

Department of Pharmacochemistry, Faculty of Pharmacy

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Published

01-11-2017

How to Cite

Saptarini, N. M., M. S. Wibowo, and T. Gusdinar. “CORRELATION STUDY OF SERUM CALCIUM LEVELS AND SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN LEVELS IN RHEUMATOID ARTHRITIS PATIENTS IN BANDUNG, INDONESIA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 11, Nov. 2017, pp. 401-3, doi:10.22159/ajpcr.2017.v10i11.18493.

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