HEPATOPROTECTIVE ACTIVITY FROM ETHANOL EXTRACT OF PUGUN TANO'S LEAVE (Curanga fel-terrae (Lour.) Merr.)

Urip Harahap; Marianne Bastian; Sri Yuliasmi; Dadang Irfan Husori; Popi Patilaya; Lia Laila

doi:10.22159/ajpcr.2017.v10i11.19127

Authors

Urip Harahap Department of Pharmacology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
Marianne Bastian Department of Pharmacology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
Sri Yuliasmi Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
Dadang Irfan Husori Department of Pharmacology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
Popi Patilaya Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
Lia Laila Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i11.19127

Keywords:

Curanga fel-terrae (Lour) Merr, Paracetamol, Liver, Hepatoprotective

Abstract

Objective: The aim of this study is to observe the activity of ethanol extract of Curanga fel-terrae leave in preventing the damaged of liver which is induced by high dose of paracetamol.

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Methods: This research was conducted by using Wistar rat divided into 6 groups. Group 1 was the normal group. Group 2, 3, 4, 5 and 6 received CMC-Na 0.5% (negative control), C. fel-terrae ethanolic extract (CFEE) at the doses of 125, 250 and 500 mg/kg, catechin 2 mg/kg (positive control),respectively during 7 days continued and followed by given paracetamol dose of 2.5g/kg 8 hours after that. Hepatoprotective activity was carried out toward parameter of AST, ALT as well as histopathology of the liver.

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Results: The results showed that high-dose paracetamol dose of 2.5g/kg bw can cause liver damaged which can be seen by the increasing of the level of AST and ALT compared to the normal group (p<0.05). The usage of three doses of CFEEfor 7 days showed the prevention of the increasing of the level of AST and ALT compared to negative control group (p<0.05). Furthermore, the histopathology study revealed that the three doses of extract could protect the liver.

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Conclusion: The C. fel-terrae ethanolic extract (CFEE) at the doses of 125, 250 and 500 mg/kg bw which was given for 7 days can prevent the liver from the damage caused by high-dose of paracetamol.

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Keyword: Curanga fel-terrae (Lour.) Merr., paracetamol, liver, hepatoprotectiveÂ Â

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