MALAYSIAN MEDICINAL PLANTS' POTENTIAL FOR BREAST CANCER THERAPY
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i6.24322Keywords:
Breast cancer, Medicinal plants, Bioactive components, Anticancer mechanismAbstract
Objective: This review focused on Malaysian medicinal plants that have been evaluated and pose potentials to treat breast cancer.
Methods: Google Scholar, Web of Science, PubMed, Scopus, Biomed, ResearchGate, academia.edu, IEEE Xplore, ScienceDirect, and Ingenta databases were searched for this review and studies reported between January 1st, 2010 and June 30th, 2016.
Results: A total of 105 plants species representing 54 different families and 79 genera were reviewed. 97% of the plants were tested using MCF-7 and MDA-231 breast cancer cell lines and exhibited most significant in vitro anticancer activity, and 3% were tested using another type of breast cancer cell lines. Most of the bioactive compounds of the medicinal plants that exhibited good activity (IC50 values <120 μg/mL) are a group of phenols, alkaloids, flavonoids, terpenoids, and saponins. Induction of apoptosis was found to be the significant cell death pathway.
Conclusion: This article reviews the available literature concerning research on anti-breast cancer plants. Furthermore, identification and characterization of active components and toxicology evaluation also need to be studied in details and also point out their clinical trials.
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References
Sawadogo WR, Schumacher M, Teiten MH, Dicato M, Diederich M. Traditional west african pharmacopeia, plants and DERIVED compounds for cancer therapy. Biochem Pharmacol 2012;84:1225-40.
Dawson SJ, Makretsov N, Blows FM, Driver KE, Provenzano E, Le Quesne J, et al. BCL2 in breast cancer: A favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received. Br J Cancer 2010;103:668-75.
Amin A, Mousa M. Merits of anti-cancer plants from the Arabian Gulf region. Cancer Ther 2007;5:55-66.
Kurman RJ. Cancer IAfRo, Organization WH: WHO Classification of Tumours of Female Reproductive Organs: International Agency for Research on Cancer; 2014.
Abu Bakar MF, Abdul Karim F, Suleiman M, Isha A, Rahmat A. Phytochemical constituents, antioxidant and antiproliferative properties of a liverwort, lepidozia borneensis stephani from mount kinabalu, sabah, malaysia. Evid Based Complement Alternat Med 2015;2015:936215.
Mohanlal S. Phytochemical Investigations on ‘Black Glumed’njavara (Oryza sativa l.), the Medicinal Rice, as Compared to Staple Varieties and Evaluation of their Antioxidant, Anti-inflammatory and Anticancer Effects. Pennsylvania State University: Citeseer; 2011.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015;65:5-29.
Hussein R, Anuar H. Report of the Second National Health and Morbidity Survey Conference. Hospital Kuala Lumpur; 1997. p. 22.
Norsa’adah B, Rusli BN, Imran AK, Naing I, Winn T. Risk factors of breast cancer in women in kelantan, malaysia. Singapore Med J 2005;46:698-705.
Khazir J, Mir BA, Pilcher L, Riley DL. Role of plants in anticancer drug discovery. Phytochem Lett 2014;7:173-81.
Bhoo-Pathy N, Yip CH, Hartman M, Uiterwaal CS, Devi BC, Peeters PH, et al. Breast cancer research in asia: Adopt or adapt western knowledge? Eur J Cancer 2013;49:703-9.
Lim GC. Overview of cancer in Malaysia. Jpn J Clin Oncol 2002;32Suppl 1:S37-S42.
von Minckwitz G, Untch M, Blohmer JU, Costa SD, Eidtmann H, Fasching PA, et al. Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. J Clin Oncol 2012;30:1796-804.
Cazzaniga M, Bonanni B. Breast cancer chemoprevention: Old and new approaches. BioMed Res Int 2012;2012:985620.
Sinha D, Biswas J, Sung B, Aggarwal BB, Bishayee A. Chemopreventive and chemotherapeutic potential of curcumin in breast cancer. Curr Drug Targets 2012;13:1799-819.
Davies C, Pan H, Godwin J, Gray R, Arriagada R, Raina V, et al. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at five years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet 2013;381:805-16.
Waters EA, McNeel TS, Stevens WM, Freedman AN. Use of tamoxifen and raloxifene for breast cancer chemoprevention in 2010. Breast Cancer Res Treat 2012;134:875-80.
Chumsri S, Howes T, Bao T, Sabnis G, Brodie A. Aromatase, aromatase inhibitors, and breast cancer. J Steroid Biochem Mol Biol 2011;125:13-22.
Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, et al. Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial. Lancet 2010;376:235-44.
Gianni L, Dafni U, Gelber RD, Azambuja E, Muehlbauer S, Goldhirsch A, et al. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: A 4-year follow-up of a randomised controlled trial. Lancet Oncol 2011;12:236-44.
Rebucci M, Michiels C. Molecular aspects of cancer cell resistance to chemotherapy. Biochem Pharmacol 2013;85:1219-26.
Holohan C, Van Schaeybroeck S, Longley DB, Johnston PG. Cancer drug resistance: An evolving paradigm. Nat Rev Cancer 2013;13:714-26.
Safarzadeh E, Sandoghchian Shotorbani S, Baradaran B. Herbal medicine as inducers of apoptosis in cancer treatment. Adv Pharm Bull 2014;4:421-7.
Aliya S, Devi YP, Uma A. Plants as potential resources of anticancer drugs. Curr Trends Biotechnol Pharm 2016;10:92-107.
Nagaprashanthi CH, Kannan M, Karthikeyan M, Aleemuddin MA. Ethnomedicinal plants for prevention and treatment of breast cancer: A review. Int J Pharm Sci Res 2012;3:756.
Omogbadegun ZO. Medicinal plants-based foods for breast cancer treatment: An ethnobotanical survey and digitization. Int J Med Plants Alt Med 2013;1:137-63.
Sa L. Top 3 herbal drugs for breast cancer. Int J PharmTech Res 2013;5:1811-5.
Islam M, Aksharin L, Ahmed A, Moududee SA, Hossain M, Rahman M, et al. Herbal medicinal plant in the treatment of breast cancer-an overview. Int J Pharm Life Sci 2014;5:575-82.
Levitsky DO, Dembitsky VM. Anti-breast cancer agents derived from plants. Nat Prod Bioprospect 2014;5(1):1-16.
Elgadir MA, Salama M, Adam A. Anti-breast cancer from various natural sources-review. Int J Pharm Pharm Sci 2015;4:1142-53.
Jaikumar B, Jasmine R: A Review on a few medicinal plants possessing anticancer activity against human breast cancer. Int J PharmTech Res 2016;9:333-65.
Shareef M, Ashraf MA, Sarfraz M. Natural Cures for Breast Cancer Treatment. Mini Rev Med Chem 2016;16:596-604.
Nataru S, Pulicherla Y, Gaddala B. A review on medicinal plants as a potential source for cancer. Int J Pharm Sci Rev Res 2014;26:235-48.
Jordan VC. Molecular mechanisms of antiestrogen action in breast cancer. Breast Cancer Res Treat 1994;31:41-52.
Seery L, Gee J, Dewhurst O, Nicholson RI. Molecular mechanisms of antiestrogen action. In: Estrogens and Antiestrogens. Ist ed. New York: Springer; 1999. p. 201-20.
Osborne CK, Schiff R. Mechanisms of endocrine resistance in breast cancer. Annu Rev Med 2011;62:233-47.
Yue GG, Chan BC, Hon PM, Lee MY, Fung KP, Leung PC, et al. Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food Chem Toxicol 2010;48:2011-20.
Diantini A, Subarnas A, Lestari K, Halimah E, Susilawati Y, Supriyatna, et al. Kaempferol-3-O-rhamnoside isolated from the leaves of schima wallichii korth. Inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway. Oncol Lett 2012;3:1069-72.
Manoharan S, Kaur J. Anticancer, antiviral, antidiabetic, antifungal and phytochemical constituents of medicinal plants. Am J PharmTech Res 2013;3:149-69.
Cheah YH, Azimahtol HL, Abdullah NR. Xanthorrhizol exhibits antiproliferative activity on MCF-7 breast cancer cells via apoptosis induction. Anticancer Res 2006;26:4527-34.
Zan CH, Rahmat A, Abdah MDA, Akim M, Alitheen NB, Othman F, et al. Anti-proliferative effects of pandan leaves (Pandanus amarylfolius), kantan flower (Etlingera elatior) and turmeric leaves (Curcuma longa). Nutr Food Sci 2011;41:238-41.
Ghasemzadeh A, Jaafar HZ, Rahmat A, Ashkani S. Secondary metabolites constituents and antioxidant, anticancer and antibacterial activities of Etlingera elatior (Jack) RM Sm grown in different locations of Malaysia. BMC Complement Altern Med 2015;15:1.
Namvar F, Mohamed S, Fard SG, Behravan J, Mustapha NM, Alitheen NB, et al. Polyphenol-rich seaweed (Eucheuma cottonii) extract suppresses breast tumour via hormone modulation and apoptosis induction. Food Chem 2012;130:376-82.
Abdullah AS, Mohammed AS, Abdullah R, Mirghani ME, Al-Qubaisi M. Cytotoxic effects of Mangifera indica L. Kernel extract on human breast cancer (MCF-7 and MDA-MB-231 cell lines) and bioactive constituents in the crude extract. BMC Complement Altern Med 2014;14:199.
Hossain N, Mirghani M, Raus RB. Optimization of Moringa oleifera leaf extraction and investigation of anti breast cancer activity with the leaf extract. Eng Int 2015;3:97-103.
Aziz MY, Omar AR, Subramani T, Yeap SK, Ho WY, Ismail NH, et al. Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells. Oncol Lett 2014;7:1479-84.
Hasan TN, B LG, Shafi G, Al-Hazzani AA, Alshatwi AA. Anti-proliferative effects of organic extracts from root bark of Juglans regia L. (RBJR) on MDA-MB-231 human breast cancer cells: Role of bcl-2/Bax, caspases and tp53. Asian Pac J Cancer Prev 2011;12:525-30.
Rahman S, Salehin F, Iqbal A. In vitro antioxidant and anticancer activity of young Zingiber officinale against human breast carcinoma cell lines. BMC complement Altern Med 2011;11:1.
Endrini S, Suherman S, Widowati W. Annona muricata leaves have strongest cytotoxic activity against breast cancer cells. Univ Med 2015;33:179-84.
Hashim NM, Rahmani M, Ee GC, Sukari MA, Yahayu M, Oktima W, et al. Antiproliferative activity of xanthones isolated from Artocarpus obtusus. J Biomed Biotechnol 2012;2012:130627.
Sani HA, Rahmat A, Ismail M, Rosli R, Endrini S. Potential anticancer effect of red spinach (Amaranthus gangeticus) extract. Asia Pac J Clin Nutr 2004;13:396-400.
Ooi KL, Tengku Muhammad TS, Lim CH, Sulaiman SF. Apoptotic effects of physalis minima L. Chloroform extract in human breast carcinoma T-47D cells mediated by c-myc-, p53-, and caspase-3-dependent pathways. Integr Cancer Ther 2010;9:73-83.
Park SY, Kim HJ, Kim KR, Lee SK, Lee CK, Park KK, et al. Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment. Toxicol Appl Pharmacol 2014;275:152-62.
Jagetia GC, Baliga MS. Modulation of antineoplastic activity of cyclophosphamide by Alstonia scholaris in the ehrlich ascites carcinoma-bearing mice. J Exp Ther Oncol 2003;3:272-82.
Jayanthi G, Smitha K. In vitro evaluation of the anticancer effect of methanolic extract of Alstonia scholaris leaves on mammary carcinoma. J Appl Pharm Sci 2012;2:142.
Ling LT, Radhakrishnan AK, Subramaniam T, Cheng HM, Palanisamy UD. Assessment of antioxidant capacity and cytotoxicity of selected malaysian plants. Molecules 2010;15:2139-51.
Syed Najmuddin SU, Romli MF, Hamid M, Alitheen NB, Nik Abd Rahman NM. Anti-cancer effect of Annona muricata linn leaves crude extract (AMCE) on breast cancer cell line. BMC Complement Altern Med 2016;16:311.
Lee HM, Moon A. Amygdalin regulates apoptosis and adhesion in hs578T triple-negative breast cancer cells. Biomol Ther (Seoul) 2016;24:62-6.
Bhutia SK, Behera B, Das DN, Mukhopadhyay S, Sinha N, Panda PK, et al. Abrus agglutinin is a potent anti-proliferative and anti-angiogenic agent in human breast cancer. Int J Cancer 2016;139:457-66.
Capasso A. Antioxidant action and therapeutic efficacy of Allium sativum L. Molecules 2013;18:690-700.
Chen LP, Zhao F, Wang Y, Zhao LL, Li QP, Liu HW, et al. Antitumor effect of resorcinol derivatives from the roots of ardisia brevicaulis by inducing apoptosis. J Asian Nat Prod Res 2011;13:734-43.
Aisha AF, Abu-Salah KM, Alrokayan SA, Siddiqui MJ, Ismail Z, Majid AM. Syzygium aromaticum extracts as good source of betulinic acid and potential anti-breast cancer. Rev Bras Farmacog 2012;22:335-43.
Devi JR, Thangam EB. Mechanisms of anticancer activity of sulforaphane from Brassica oleracea in HEp-2 human epithelial carcinoma cell line. Asian Pac J Cancer Prev 2012;13:2095-100.
Arisanty D. In vitro cytotoxic study and detection of apoptosis on breast cancer cell lines MDA-MB 231 after exposed to Azadirachta indica A. juss (neem) extract. J Kesehatan Andalas 2013;2:80-4.
Aslam J, Khan SH, Siddiqui ZH, Fatima Z, Maqsood M, Bhat MA, et al. Catharanthus roseus (L.) G. Don. An important drug: It’s applications and production. Pharm Glob (IJCP) 2010;4:1-16.
Ahmad NH, Rahim RA, Mat I. Catharanthus roseus aqueous extract is cytotoxic to Jurkat leukaemic T-cells but induces the proliferation of normal peripheral blood mononuclear cells. Trop Life Sci Res 2010;21:101.
Rajalakshmi M, Anita R. In vitro and in silico evaluation of antioxidant activity of a sesquiterpene lactone, costunolide, isolated from costus speciosus rhizome on mcf-7 and mda-mb-231 human breast cancer cell lines. World J Pharm Pharm Sci 2014;3:1334-47.
El-Far AH, Badria FA, Shaheen HM. Possible anticancer mechanisms of some Costus speciosus active ingredients concerning drug discovery. Curr Drug Discovery Technol 2016;13:123-43.
Andrade S. Physical, chemical and biochemical changes of sweetsop (Annona squamosa L.) and golden apple (Spondias citherea sonner) fruits during ripening. J Agric Sci Technol B 2012;2:1148.
Bakar MF, Mohamed M, Rahmat A, Fry J. Phytochemicals and antioxidant activity of different parts of bambangan (Mangifera pajang) and tarap (Artocarpus odoratissimus). Food Chem 2009;113:479-83.
Alabsi AM, Ali R, Ali AM, Harun H, Al-Dubai SA, Ganasegeran K, et al. Induction of caspase-9, biochemical assessment and morphological changes caused by apoptosis in cancer cells treated with goniothalamin extracted from Goniothalamus macrophyllus. Asian Pac J Cancer Prev 2013;14:6273-80.
Seyed MA, Jantan I, Bukhari SN. Emerging anticancer potentials of Goniothalamin and its molecular mechanisms. BioMed Res Int 2014;2014:536508.
Hew CS, Khoo BY, Gam LH. The anti-cancer property of proteins extracted from Gynura procumbens (Lour.) Merr. PLoS One 2013;8:e68524.
Singh DK, Luqman S. Lawsonia inermis (L.): A perspective on anticancer potential of mehndi/henna. Biomed Res Ther 2014;1:112-20.
El-Babili F, Bouajila J, Valentin A, Chatelain C. Lawsonia inermis: Its anatomy and its antimalarial, antioxidant and human breast cancer cells MCF7 activities. Pharm Anal Acta 2013;4:1-6.
Reddy NS, Navanesan S, Sinniah SK, Wahab NA, Sim KS. Phenolic content, antioxidant effect and cytotoxic activity of Leea indica leaves. BMC Complement Altern Med 2012;12:128.
Nurhanan M, Asiah O, Ilham MM, Syarifah MS, Norhayati I, Sahira HL. Anti-proliferative activities of 32 Malaysian plant species in breast cancer cell lines. J Trop For Sci 2008;2008:77-81.
Fang EF, Ng TB. A trypsin inhibitor from rambutan seeds with antitumor, anti-HIV-1 reverse transcriptase, and nitric oxide-inducing properties. Appl Biochem Biotechnol 2015;175:3828-39.
Banerjee M, Chattopadhyay S, Choudhuri T, Bera R, Kumar S, Chakraborty B, et al. Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line. J Biomed Sci 2016;23:40.
Leong OK, Muhammad TS, Sulaiman SF. Cytotoxic activities of Physalis minima L. Chloroform extract on human lung adenocarcinoma NCI-H23 cell lines by induction of apoptosis. Evid Based Complement Alternat Med 2011;2011:185064.
Suhail MM, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, et al. Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells. BMC Complement Altern Med 2011;11:129.
Afsar V, Reddy M, Saritha K. In vitro antioxidant activity and anti inflammatory activity of methanolic leaf extract of Boswellia serrata. Int J Life Sci Biotech Pharm Res 2012;1:15-23.
Sofi MS, Sateesh M, Bashir M, Harish G, Lakshmeesha T, Vedashree S, et al. Cytotoxic and pro-apoptotic effects of Abrus precatorius L. on human metastatic breast cancer cell line, MDA-MB-231. Cytotechnology 2013;65:407-17.
Ibahim M, Wan-Nor I, Narimah A, Sar SN, Froemming G. Anti-proliperative and antioxidant effects of Tinospora crispa (Batawali). Biomed Res 2011;22:57-62.
Marvibaigi M, Amini N, Supriyanto E, Abdul Majid FA, Kumar Jaganathan S, Jamil S, et al. Antioxidant activity and ROS-dependent apoptotic effect of Scurrula ferruginea (Jack) danser methanol extract in human breast cancer cell MDA-MB-231. PLoS One 2016;11:e0158942.
Marvibaigi M, Amini N, Supriyanto E, Jamil S, Majid FA, Khangholi S. Total phenolic content, antioxidant and antibacterial properties of Scurrula ferruginea extracts. J Teknol 2014;70:65-72.
Jadhao D, Thorat B. Purification (crystallization) of bioactive ingredient andrographolide from Andrographis paniculata. World J Pharm Pharm Sci 2014;3:747-63.
Hossain MS, Urbi Z, Sule A, Rahman K: Andrographis paniculata (Burm. f.) Wall. ex Nees: A review of ethnobotany, phytochemistry, and pharmacology. Sci World J 2014;2014:1-28.
Kuppusamy P, Ichwan SJ, Parine NR, Yusoff MM, Maniam GP, Govindan N. Intracellular biosynthesis of Au and Ag nanoparticles using ethanolic extract of Brassica oleracea L. and studies on their physicochemical and biological properties. J Environ Sci 2015;29:151-7.
Singh J, Upadhyay A, Bahadur A, Singh B, Singh K, Rai M. Antioxidant phytochemicals in cabbage (Brassica oleracea L. var. capitata). Sci Hortic 2006;108:233-7.
Tor YS, Yazan LS, Foo JB, Armania N, Cheah YK, Abdullah R, et al. Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa. BMC Complement Altern Med 2014;14:55.
Karimi E, Jaafar HZ, Ahmad S. Antifungal, anti-inflammatory and cytotoxicity activities of three varieties of labisia pumila benth: From microwave obtained extracts. BMC Complement Altern Med 2013;13:1.
Rasool M, Malik A, Manan A, Arooj M, Qazi MH, Kamal MA, et al. Roles of natural compounds from medicinal plants in cancer treatment: Structure and mode of action at molecular level. Med Chem 2015;11:618-28.
Sathishkumar P, Preethi J, Vijayan R, Mohd Yusoff AR, Ameen F, Suresh S, et al. Anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised silver nanoparticles using Coriandrum sativum leaf extract. J Photochem Photobiol B 2016;163:69-76.
Narrima P, Paydar M, Looi CY, Wong YL, Taha H, Wong WF, et al. Persea declinata (Bl.) kosterm bark crude extract induces apoptosis in MCF-7 cells via G0/G1 cell cycle arrest, bcl-2/Bax/Bcl-xl signaling pathways, and ROS generation. Evid Based Complement Alternat Med 2014;2014:248103.
Nassar ZD, Aisha AA, Majid AM. The Pharmacological Properties of Terpenoids from Sandoricum koetjape; 2010.
Tang EL, Rajarajeswaran J, Fung SY, Kanthimathi MS. Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migration. BMC Complement Altern Med 2013;13:347.
Hasanzadeh G, Latiffah AL, Hanachi P, Lajis NH. Effect of linoleic acid of Nigella sativa on MDA-MB-231 human breast cancer cells. Iran J Cancer Prev 2011;4:65-70.
Paydar M, Wong YL, Moharam BA, Wong WF, Looi CY. In vitro anti-oxidant and anti-cancer activity of methanolic extract from Sanchezia speciosa leaves. Pak J Biol Sci 2013;16:1212-5.
Ho KL, Chung WE, Choong KE, Cheah YL, Phua EY, Srinivasan R. Anti-proliferative activity and preliminary phytochemical screening of Ipomoea quamoclit leaf extracts. Res J Med Plant 2015;9:127-34.
Teoh PL, Ali R, Cheong B. Potential anticancer effect of Phyla nodiflora extracts in breast cancer cell line, MCF7. World J Pharm Pharm Sci 2013;2:6053-61.
Abdullah H, Pihie AH, Hohmann J, Molnár J. A natural compound from Hydnophytum formicarium induces apoptosis of MCF-7 cells via up-regulation of Bax. Cancer Cell Int 2010;10:14.
Muhamad S, Pihie AH, Latif J, Rha C, Sambandan T. Induction of apoptosis in MCF-7 via the Caspase pathway by longilactone from Eurycoma longifolia Jack. Res Pharm Biotechnol 2011;3:1-10.
Looi CY, Arya A, Cheah FK, Muharram B, Leong KH, Mohamad K, et al. Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds. PLoS One 2013;8:e56643.
Abu Bakar MF, Mohamad M, Rahmat A, Burr SA, Fry JR. Cytotoxicity, cell cycle arrest, and apoptosis in breast cancer cell lines exposed to an extract of the seed kernel of Mangifera pajang (bambangan). Food Chem Toxicol 2010;48:1688-97.
Ahmad S, Sukari MA, Ismail N, Ismail IS, Abdul AB, Bakar MF, et al. Phytochemicals from Mangifera pajang kosterm and their biological activities. BMC Complement Altern Med 2015;15:1.
Ghil S. Antiproliferative activity of Alpinia officinarum extract in the human breast cancer cell line MCF-7. Mol Med Reports 2013;7:1288-92.
Wong FC, Woo CC, Hsu A, Tan BK. The anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways. PLoS One 2013;8:e78021.
Awang K, Azmi MN, Aun LI, Aziz AN, Ibrahim H, Nagoor NH, et al. The apoptotic effect of 1’s-1’-acetoxychavicol acetate from Alpinia conchigera on human cancer cells. Molecules 2010;15:8048-59.
Zakaria ZA, Mohamed AM, Jamil NS, Rofiee MS, Hussain MK, Sulaiman MR, et al. In vitro antiproliferative and antioxidant activities of the extracts of Muntingia calabura leaves. Am J Chin Med 2011;39:183-200.
Appiah-opong R, Asante IK, Safo DO, Tuffour I, Ofori-attah E, Uto T, et al. Cytotoxic effects of Albizia zygia (dc) of macabre, a ghanaian medicinal plant, against human t-lymphoblast-like leukaemia, prostate and breast cancer cell lines. Int J Pharm Pharm Sci 2016;8:392-6.
Kokila K, Priyadharshini SD, Sujatha V. Phytopharmacological properties of Albizia species: A review. Int J Pharm Pharm Sci 2013;5:70-3.
Ong H, Norzalina J. Malay herbal medicine in Gemencheh, Negri Sembilan, Malaysia. Fitoterapia 1999;70:10-4.
Sathishkumar P, Vennila K, Jayakumar R, Yusoff AR, Hadibarata T, Palvannan T. Phyto-synthesis of silver nanoparticles using Alternanthera tenella leaf extract: An effective inhibitor for the migration of human breast adenocarcinoma (MCF-7) cells. Bioprocess Biosyst Eng 2016;39:651-9.
Ozsoy N, Yilmaz T, Kurt O, Can A, Yanardag R. In vitro antioxidant activity of Amaranthus lividus L. Food Chem 2009;116:867-72.
Roslida A, Fezah O, Yeong L. Suppression of DMBA/croton oil-induced mouse skin tumour promotion by Ardisia crispa root hexane extract. Asian Pac J Cancer Prev 2011;12:665-9.
Hamsin DE, Hamid RA, Yazan LS, Taib CN, Yeong LT. Ardisia crispa roots inhibit cyclooxygenase and suppress angiogenesis. BMC Complement Altern Med 2014;14:1.
Veerakumar S, Amanulla SS, Ramanathan K. Anti-cancer efficacy of ethanolic extracts from various parts of Annona squamosa on MCF-7 cell line. J Pharm Phytother 2016;8:147-54.
Mariod AA, Abdelwahab SI, Elkheir S, Ahmed YM, Fauzi PN, Chuen CS. Antioxidant activity of different parts from Annona squamosa, and Catunaregam nilotica methanolic extract. Acta Sci Pol Technol Aliment 2012;11:249-58.
Nguyen MT, Nguyen NT, Awale S. Chapter four-prenylated dihydrochalcones from Artocarpus altilis as antiausterity agents. Enzymes 2015;37:95-110.
Sikarwar MS, Hui BJ, Subramaniam K, Valeisamy BD, Yean LK, Kaveti B. A review on Artocarpus altilis (Parkinson) Fosberg (breadfruit). J Appl Pharm 2014;4:91-7.
Zakaria Z, Rofiee M, Teh L, Salleh M, Sulaiman M, Somchit M. Bauhinia purpurea leaves’ extracts exhibited in vitro antiproliferative and antioxidant activities. Afr J Biotechnol 2011;10:65.
Balijepalli M, Rou C, Pichika M. Antiproliferative activity of Bauhinia blakeana on estrogen receptor negative human breast cancer (MDA-MB-231) cells. Planta Med 2010;76:P95.
Arbab IA, Abdul AB, Sukari MA, Abdullah R, Syam S, Kamalidehghan B, et al. Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with the involvement of NF-κB signalling and G0/G1 cell cycle arrest: A bioassay-guided approach. J Ethnopharmacol 2013;145:343-54.
Wong SK, Lim YY, Abdullah NR, Nordin FJ. Assessment of antiproliferative and antiplasmodial activities of five selected Apocynaceae species. BMC Complement Altern Med 2011;11:1.
Thoennissen N, O’kelly J, Lu D, Iwanski G, La D, Abbassi S, et al. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and-negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene 2010;29:285-96.
Jayakumar J, Nirmala P, Kumar BP, Kumar AP. Evaluation of protective effect of myricetin, a bioflavonoid in dimethyl benzanthracene-induced breast cancer in female Wistar rats. South Asian J Cancer 2014;3:107.
Maisarah A, Asmah R, Fauziah O. Proximate analysis, antioxidant and antiproliferative activities of different parts of Carica papaya. J Nutr Food Sci 2014;4:1-7.
Ismail M, Bagalkotkar G, Iqbal S, Adamu HA. Anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to Malaysia. Molecules 2012;17:5745-56.
Bidinotto LT, Costa CA, Salvadori DM, Costa M, Rodrigues MA, Barbisan LF. Protective effects of lemongrass (Cymbopogon citratus STAPF) essential oil on DNA damage and carcinogenesis in female Balb/C mice. J Appl Toxicol 2011;31:536-44.
Piaru SP, Perumal S, Cai LW, Mahmud R, Majid AM, Ismail S, et al. Chemical composition, anti-angiogenic and cytotoxicity activities of the essential oils of Cymbopogan citratus (lemon grass) against colorectal and breast carcinoma cell lines. J Essential Oil Res 2012;24:453-9.
Halabi MF, Sheikh BY. Anti-proliferative effect and phytochemical analysis of Cymbopogon citratus extract. BioMed Res Int 2014;2014:906239.
Syed Abdul Rahman SN, Abdul Wahab N, Abd Malek SN. In vitro morphological assessment of apoptosis induced by antiproliferative constituents from the rhizomes of Curcuma zedoaria. Evid Based Complement Alternat Med 2013;2013:257108.
Dashora N, ay Sodde V, Prabhu KS, Lobo R. In vitro cytotoxic activity of Dendrophthoe falcata on human breast aclenocarcinoma cells-MCF-7. Int J Cancer Res 2011;7:47-54.
Zainuddin NA, Sul’ain MD. Phytochemical analysis, toxicity and cytotoxicity evaluation of Dendropthoe pentandra leaves extracts. Int J Appl Biol Pharm Tech 2015;6:108-16.
Widowati W, Mozef T, Risdian C, Yellianty Y. Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines. Oxid Antioxid Med Sci 2013;2:137-42.
Ting K, Othman M, Telford G, Clarke G, Bradshaw T, Khoo T, et al. Antioxidant, cytoprotective, growth inhibitory and immunomodulatory activities of extracts of Dysoxylum cauliflorum Hiern., a malaysian meliaceae. J Med Plants Res 2011;5:5867-72.
Chicca A, Adinolfi B, Pellati F, Orlandini G, Benvenuti S, Nieri P. Cytotoxic activity and G1 cell cycle arrest of a dienynone from Echinacea pallida. Planta Med 2010;76:444-6.
Hotel I, Lumpur K. 33rd Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology. Kuala Lumpur: Istana Hotel; 2008.
Ho WY, Yeap SK, Ho CL, Raha AR, Suraini AA, Alitheen NB. Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. J Med Plants Res 2011;5:5741-9.
Harun FB, Jamalullail SM, Yin KB, Othman Z, Tilwari A, Balaram P. Autophagic cell death is induced by acetone and ethyl acetate extracts from Eupatorium odoratumin vitro: Effects on MCF-7 and vero cell lines. Sci World J 2012;20:1-9.
Rosnah J, Khandaker M, Boyce A. Ficus deltoidea: Review on Background and recent pharmacological potential. J Agronomy 2015;14:310.
Artanti N, Hanafi M, Andriyani R, Saraswaty V, Udin LZ, Lotulung PD, et al. Isolation of an anti-cancer asperuloside from Hedyotis corymbosa L. J Trop Life Sci 2015;5:88-91.
Lee YK, Lay LK, Mahsufi MS, Guan TS, Elumalai S, Thong OM. Anti-proliferation effect of Hevea brasiliensis latex B-serum on human breast epithelial cells. Pak J Pharm Sci 2012;25:645-50.
Kumkum A, Ranjana V. Inhibition of calcium oxalate crystallization in vitro by various extracts of Hyptis suaveolens (L.) Poit. Int Res J Pharm 2012;3:261-4.
Pihie AH, Zakaria ZA, Othman F. Antiproliferative and proapoptotic effects of Labisia pumila ethanol extract and its active fraction in human melanoma HM3KO cells. Evid Based Complement Altern Med 2012;2012:123470.
Al-Mekhlafi NA, Shaari K, Abas F, Kneer R, Jeyaraj EJ, Stanslas J, et al. Alkenylresorcinols and cytotoxic activity of the constituents isolated from Labisia pumila. Phytochemistry 2012;80:42-9.
Kutoi CJ, Yen KH, Seruji NM. Pharmacology evaluation of Litsea garciae (Lauraceae). In: Business Engineering and Industrial Applications Colloquium (BEIAC): IEEE; 2012. p. 31-33.
GarcÃa-Rivera D, Delgado R, Bougarne N, Haegeman G, Berghe WV. Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. Bark in MDA-MB231 breast cancer cells. Cancer Lett 2011;305:21-31.
Roslen NA, Alewi NA, Ahamada H, Rasad MS. Cytotoxicity screening of Melastoma malabathricum extracts on human breast cancer cell lines in vitro. Asian Pac J Trop Biomed 2014;4:545-8.
Khalafalla MM, Abdellatef E, Dafalla HM, Nassrallah AA, Aboul-Enein KM, Lightfoot DA. Active principle from Moringa oleifera Lam leaves effective against two leukemias and a hepatocarcinoma. Afr J Biotechnol 2010;9:8467.
Ghasemzadeh A, Jaafar HZ, Rahmat A, Devarajan T. Evaluation of bioactive compounds, pharmaceutical quality, and anticancer activity of curry leaf (Murraya koenigii L.). Evid Based Complement Altern Med 2014;2014. Article ID 873803.
Sayar K, Paydar M, Pingguan-Murphy B. Pharmacological properties and chemical constituents of Murraya paniculata (L.) Jack. Med Aromat Plants 2014;3:173.
Basheer MK, Majid AM. Medicinal Potentials of Orthosiphon stamineus Benth. WebmedCentral Cancer 2010;1:WMC0013612010.
Ooi DJ, Iqbal S, Ismail M. Proximate composition, nutritional attributes and mineral composition of Peperomia pellucida L.(Ketumpangan Air) grown in Malaysia. Molecules 2012;17:11139-45.
Wei LS, Wee W, Siong JY, Syamsumir DF. Characterization of anticancer, antimicrobial, antioxidant properties and chemical compositions of Peperomia pellucida leaf extract. Acta Med Iran 2011;49:670.
Hendra R, Ahmad S, Oskoueian E, Sukari A, Shukor MY. Antioxidant, anti-inflammatory and cytotoxicity of Phaleria macrocarpa (Boerl.) scheff fruit. BMC Complement Altern Med 2011;11:1.
Ee GC, Lim CM, Rahmani M, Shaari K, Bong CF. Pellitorine, a potential anti-cancer lead compound against HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum. Molecules 2010;15:2398-404.
Sul’ain MD, Zazali KE, Ahmad N. Screening on anti-proliferative activity of Psidium guajava leaves extract towards selected cancer cell lines. J US China Med Sci 2012;9:30-7.
Masaud IA, Baig AA, Rohin MA, Mohamad N. Potential of therapeutic antioxidant compounds from pomegranate as anti-cancer agent. J Chem Pharm Res 2014;6:427-33.
Kim KH, Kim CS, Park YJ, Moon E, Choi SU, Lee JH, et al. Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus. Bioorg Med Chem Lett 2015;25:96-9.
Hu X, Zhang X, Qiu S, Yu D, Lin S. Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. Biochem Biophys Res Comm 2010;398:62-7.
Rahmat A, Edrini S, Ismail P, Yap T, Hin Y, Bakar MA. Chemical constituents, antioxidant activity and cytotoxic effects of essential oil from Strobilanthes crispus and Lawsonia inermis. J Biol Sci 2006;6:1005-10.
Ibahim M, I’zzah WN, Narimah A, Asyikin NZ, Shafinas SN, Froemming G. Anti-proliperative and antioxidant effects of Tinospora crispa (Batawali). Biomed Res India 2011;22:57-62.
Bhagat N, Chaturvedi A. Spices as an alternative therapy for cancer treatment. Syst Rev Pharm 2016;7:46-56.
Ayob Z, Samad AA, Bohari SP. Cytotoxicity activities in local Justicia gendarussa crude extracts against human cancer cell lines. J Teknol 2013;64:45-52.
Ling AL, Yasir S, Matanjun P, Bakar MF. Effect of different drying techniques on the phytochemical content and antioxidant activity of Kappaphycus alvarezii. J Appl Phycol 2015;27:1717-23.
Baharum Z, Akim AM, Taufiq-Yap YH, Hamid RA, Kasran R. In vitro antioxidant and antiproliferative activities of methanolic plant part extracts of Theobroma cacao. Molecules 2014;19:18317-31.
Nurrochmad A, Lukitaningsih E, Meiyanto E. Anti cancer activity of rodent tuber (Thyphonium flagelliforme (lodd.) Blume on human breast cancer t47d cells. Int J Phytomed 2011;3:138.
Mohan S, Abdul AB, Abdelwahab SI, Al-Zubairi AS, Sukari MA, Abdullah R, et al. Typhonium flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP cleavage and cytochrome c release: Its activation coupled with G0/G1 phase cell cycle arrest. J Ethnopharmacol 2010;131:592-600.
Srisawat T, Chumkaew P, Heed-Chim W, Sukpondma Y, Kanokwiroon K. Phytochemical screening and cytotoxicity of crude extracts of Vatica diospyroides symington type LS. Trop J Pharm Res 2013;12:71-6.
Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther 2013;12:312-22.
Ghasemzadeh A, Jaafar HZ. Antioxidant potential and anticancer activity of young ginger (Zingiber officinale Roscoe) grown under different CO2 concentration. J Med Plants Res 2011;5:3247-55.
Raghavendra L, PrashithKekuda R. Ethnobotanical uses, phytochemistry and pharmacological activities of Peperomia pellucida (L.) Kunth (piperaceae)-a review. Int J Pharm Pharm Sci 2018;10:1-8.
Shamsi T, Parveen R, Sajida A, Ahmad A, Fatima S. Assessing the therapeutic role of joshanda: Phytochemical, antioxidant, anti-inflammatory and antimicrobial activities. Int J Pharm Pharm Sci 2018;10:122-8.
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