CYTOTOXICITY OF STRAWBERRY EXTRACT ON ORAL CANCER CELL LINE
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i9.25955Keywords:
Apoptosis, Berries, Cancer, Cytotoxic effect, (3-[4, 5-Dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide), Neutral redAbstract
Objective: Berries including strawberry may have beneficial effects against oxidative stress-mediated diseases such as cancer. The purpose of the present study was to investigate the cytotoxic effects of strawberry extract on oral cancer cell line.
Methods: Strawberry methanolic extract (SBE) was prepared, and cytotoxic activity of different concentration of SBE on KB cell lines was determined by (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay and neutral red dye incorporation test.
Results: Strawberry extract exhibits cytotoxic activity over the oral cancer cell lines. On administration of about 100 μg/ml of strawberry extract, about 50% of cell viability could be observed and assessed from the cell lines.
Conclusion: Strawberries have a cytotoxic effect on oral cancer cell line due to the presence of anticancer constituents in the berries. These berries can be used as a natural medicine for cancer sufferers.
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