ANTIASTHMATIC ACTIVITY OF THE ETHANOL EXTRACT OF LEAVES OF WRIGHTIA TINCTORIA

Authors

  • Zaseem Khan Department of Pharmacology, Oriental College of Pharmacy, Sanpada, Navi Mumbai - 400 705, Maharashtra, India.
  • Imtiyaz Ansari Department of Pharmacology, Oriental College of Pharmacy, Sanpada, Navi Mumbai - 400 705, Maharashtra, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i9.26151

Keywords:

Antiasthmatic, Milk, Ovalbumin, Wrightia tinctoria, Leukocytosis

Abstract

Objective: The objective of this study was to evaluate the antiasthmatic activity of ethanolic extract of Wrightia tinctoria leaves in albino wistar rats.

Methods: The plant extract was taken by soxhlet apparatus with 90% ethanol. Two methods are carried out such as milk-induced leukocytosis and ovalbumin-induced leukocytosis; (4 ml/kg) milk induced as intoxicant given by subcutaneous, (4 ml/kg) ovalbumin given by intraperitoneal injection, and standard drug as dexamethasone (50 mg/kg) given for both activity and drug extract for all three test groups (low, medium, and high) blood collected from the retro-orbital plexus and count the leukocytes before and after 24 h after drug administration.

Result: Test 1, Test 2, and Test 3 groups were found to significantly (**p<0.01) decrease ambulation counts as compared to milk and ovalbumin control group. The treatment group was founded to significantly (**P<0.01) milk and ovalbumin control group increases ambulation count as compared to all test groups and standard groups.

Conclusion: In this study, we conclude that an ethanolic extract of the leaves of W. tinctoria possesses a significant antiasthmatic property, which is probably mediated through inhibition of histamine. The activity shown by ethanolic extract of W. tinctoria was found to be dose dependent.

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Published

07-09-2018

How to Cite

Khan, Z., and I. Ansari. “ANTIASTHMATIC ACTIVITY OF THE ETHANOL EXTRACT OF LEAVES OF WRIGHTIA TINCTORIA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 9, Sept. 2018, pp. 136-9, doi:10.22159/ajpcr.2018.v11i9.26151.

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Original Article(s)