A PHARMACOGNOSTICAL AND PHARMACOLOGICAL REVIEW ON BRYOPHYLLUM PINNATUM (PANPHUTI)
DOI:
https://doi.org/10.22159/ajpcr.2019.v12i1.28988Keywords:
Alkaloids, Bryophyllum pinnatum, Bufadienolides, Flavonoids, Hepatoprotective, Immunosuppressive, PhytoconstituentsAbstract
Bryophyllum pinnatum is usually known as Panphuti which belong to family Crassulaceae growing widely in tropical Africa, tropical America, India, China, and Australia. It is a perennial herb grows 3–5 feet tall, fleshy dark green leaves that are distinctively scalloped and trimmed in red, and bell-like pendulous flowers. The plant contains various active compounds such as alkaloids, triterpenes, glycosides, flavonoids, steroids, bufadienolides, lipids, and organic acids. The pharmacological studies are reviewed and discussed, focusing on that different extracts from this plant have anti-inflammatory, antiallergic, antianaphylactic, antileishmanial, antitumorous, antiulcerous, antibacterial, gastroprotective, immunosuppressive, insecticidal, muscle relaxant, sedative, central nervous system depressant, and analgesic. Conventionally, it is used for the treatment of fever, constipation, nourishment of the hair and treating grey hair, intestinal disorder, and leucorrhea. The current review is created with an intended to focus on the numerous ethnobotanical and traditional use as well as the phytochemical and pharmacological report on B. pinnatum.
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References
Sharma A, Shanker C, Tyagi LK, Singh M, Rao CV. Herbal medicine for market potential in India: An overview. Acad J Plant Sci 2008;1:26 36.
Kane SG. Extracts from Plant and Non-plant Biomass and Uses Thereof. US Application Publication, Publication No. US2004/0156920 A1; 2004. Available from: http://www.ip.com/patapp/US20040156920.
Simões-Wüst AP, Grãos M, Duarte CB, Brenneisen R, Hamburger M, Mennet M, et al. Juice of Bryophyllum pinnatum (Lam.) inhibits oxytocin-induced increase of the intracellular calcium concentration in human myometrial cells. Phytomedicine 2010;17:980-6.
Biswas SK. Assesment of cytotoxicity and antibacterial activities of ethanolic extracts of Kalanchoe pinnata Linn. (Family: Crassulaceae) leaves and stem. Int J Pharm Sci Res 2011;2:2605-9.
Nayak BS, Marshall JR, Isitor G. Wound healing potential of ethanolic extract of Kalanchoe pinnata Lam. Leaf-A preliminary study. Indian J Exp Biol 2010;48:572-6.
Pathak D, Alam K, Rohilla H, Rai AR, Agrawal A. Phytochemical investigation of Boerhavia diffusa and Rograph paniculata: A comparative study. Int J Pharm Pharm Sci 2012;4:975-1491.
Mohanty S, Parida R, Sandeep IS, Sahoo S, Nayak S. Evaluation of drug yielding potential of micropropagated Curcuma aromatica. Int J Pharm Pharm Sci 2015;7:975-1491.
Available from: http://keyserver.lucidcentral.org/weeds/data/03030800-0b07-490a. [Last accessed on 2014 Sep 17].
Available from: http://www.keyserver.lucidcentral.org/weeds/data/03030800-0b07-490a8d040605030c0f01/media/Html/Bryophyllum_pinnatum.htm. [Last accessed on 2014 Sep 17].
Gurudeva MR. Botanical and Vernacular Names of South Indian Plants. Bangalore: Divya Chandra Prakashana; 2001. p. 245-246.
Chunekar KC, Pandey GS. In: Nighantu B, editor. Bhavamishra. Varanasi: Chaukhambha Bharathi Academy; 2010. p. 107.
Available from: http://www.somemagneticislandplants.com.au/index.php/plants/396-Bryophyllum-pinnatum. [Last accessed on 2014 Sep 17].
Kirthikar KR, Basu B. Indian Medicinal Plants Bryophyllum pinnatum (Lam.) Kurz (Crassulaceae). Allhebad: Lelitmohan Basu; 2002. p. 999 1000.
Khare CP. Encyclopedia of Indian Medicinal Plants. New York: Springer; 2004. p. 276.
Kanika P. Pharmacognostic and phytochemical evaluation of Bryophyllum pinnatum leaves. J Adv Sci Res 2011;2;42-9.
Nguelefack TB, Nana P, Atsamo AD, Dimo T, Watcho P, Dongmo AB, et al. Analgesic and anticonvulsant effects of extracts from the leaves of Kalanchoe crenata (Andrews) haworth (Crassulaceae). J Ethnopharmacol 2006;106:70-5.
Okwu DE, Josiah C. Evaluation of the chemical composition of two Nigerian medicinal plants. Afr J Biotechnol 2006;5:357-61.
Nielsen AH, Olsen CE, Moller BL. Flavonoids inflowers of 16 Kalanchoe blossfeldiana varieties. Phytochemistry 2005;66:2829-35.
Pal S, Sen T, Chaudhari AK. Neuropsychopharmacological profile of the methanolic fraction of Bryophyllum Pinnatum leaf extract. J Pharm Pharm 1999;51:313-8.
Adinike K, Eretan OB. Purification and partial characterization of lectin from the fresh leaves of Kalanchoe crenata (And.) Haw. J Biochem Mol Biol2004;37:229-33.
Nguelefack TB, Nana P, Atsamo AD, Dimo T, Watcho P, Dongmo AB, et al. Analgesic and anticonvulsant effects of extracts from the leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae). J Ethnopharmacol 2006;106:70-5.
Liu KC, Yang SL, Roberts MF, Phillipson JD. Eupafolin rhamnosides from Kalanchoe gracilis. J Nat Prod 1989;52:970-4.
Misra S, Dixit S. Antifungal activity of leaf extract of some higher plants. Acta Bot Indica 1979;7:147-50.
Ram PR, Mehrotra BN. Compendium of Indian Medicinal Plants. New Delhi: Drug Research Institute; 2004.
Quazi M, Sayyed N, Sheikh S, Gomase P, Choudhari A. Phytochemical analysis of chloroform extract of roots of Kalanchoe pinnata by HPLC and GCMS. Int J Pharm Sci Res 2011;2:1693-9.
von Mandac U, Plangger N, Rist L, Zimmermann R. Intravenous tocolysis with Bryophyllum pinnatum is better tolerated than betaagonis application. Eur J Obstet Gynecol Reprod Biol 2006;124:168.
Recknagael R. Carbontetrachloride hepatotoxicity. Pharm Rev 1967;19:145-96.
Almedia AP, Costa SS. Octane3-O-α-larabinopyranosyl-(16)- glucopyranoside, aminor constituent from leaves of Kalanchoe pinnata. Brazil J Pharm 2006;16:485-9.
Afzal M, Gupta G, Kazmi I, Rahman M, Afzal O, Alam J, et al. Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum. Fitoterapia 2012;83:853-8.
Amnlou M, Ariae S, Farsam H. ???. J Med Aromat Plant Sci 2005;27:469-75.
Okwu DE, Nnamdi FU. Two novel flavonoids from Bryophyllum pinnatum and their antimicrobial activity. Pharm Chem J 2011;3:1-10.
Wagner WL, Herbst DR, Sohmer SH. Manual of the Flowering Plants of Hawaii. Honolulu: Universiy Hawaii Press; 1999. p. 568.
Yamagishi T, Haruna M, Yan XZ, Chang JJ, Lee KH. Antitumor agents 110, bryophyllin B, a novel potent cytotoxic bufadienolide from Bryophyllum pinnatum. J Nat Prod 1989;52:1071-9.
Morales AL, Sanchez CV, Jerkic M, Santiago JM, Gonzalez PD, Barriocanal FP. Effect of quercetin on metallothionein, nitric acid synthases and cycloooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Toxicol Appl Pharm 2006;210:128-35.
Alabi DA, Onibudo MZ, Amusa NA. Chemicals and nutritional composition of four botanicals with fungitoxic properties. World J Agric Sci 2005;1:54-88.
Okwu DE, Josiah C. Evaluation of the chemical composition of two Nigerian medicinal plants. Afr J Biotechnol 2006;5:357-61.
Seema VP. Kalanchoe pinnata: Phytochemical and pharmacological profile. Int J Pharm Sci Res 2012;3:993-1000.
Patil PA, Shobha JC. Influence of Bryophyllum pinnatum (Lam.) leaf extract on wound healing in albino rats. J Nat Remedies 2004;4:41-6.
Pal S, Chaudhari AK. Studies on the anti-ulcer activity of a Bryophyllum pinnatum leaf extract in experimental animals. J Ethnopharmacol 1991;33:97-102.
Adesanwo JK, Raji Y, Olaleye SB, Onasanwo SA, Fadare OO, Ige OO, et al. Antiulcer activity of methanolic extract of Bryophyllum pinnatum in rats. J Biol Sci 2017;7:409-412.
Gwehenberger B, Rist L, Huch R, von Mandach u. Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility. Eur J Obstet Gynecol Reprod Bio1 2004;113:164-71.
Plangger N, Rist L, Zimmermann R, Mandach UV. Intravenous tocolysis with Bryophyllum pinnatum is better tolerated than beta-agonist application. Eur J Obstet Gynecol Reprod Biol 2006;124:168-72.
Yadav NP, Dixit VK. Hepatoprotective activity of leaves of Kalanchoe pinnata Pers. J Ethnopharm 2003;86:197-202.
Haslalka GV, Patil CR, Patil MR. Protective effect of Kalanchoe pinnata pers. (Crassulaceae) on gentamicin-induced nephrotoxicity in rats. Indian J Pharmacol 2007;39:201-5.
Pal S, Sen T, Nag AK. Neuropsychopharmacological profile of the methanolic fraction of Bryophyllum pinnatum leaf extract. J Pharm Pharm 1999;51:313-8.
Muzitano MF, Luzineide WT, Catherine G, Kaiser CR, Bergmann BR, Costa CC. The antileishmanial activity assessment of unusual flavonoids from Kalanchoe pinnata. Phytochemistry 2006;67:2071-7.
Rossi BR, Torres-Santos EC, Santos AP, Almeida AP, Costa SS, Da Silva SA. Treatment of cutaneous leishmaniasis with Kalachoe pinnata: Experimental and clinical data. Phytomedicine 2000;7:115.
Fujimori H. Potentiation of barbital hypnosis as an evaluation method for CNS depressant. Psychopharmacology 1995;7:374-7.
Salahdeen HM, Yemitan OK. Neuropharmacological effects of aqueous leaf extract of Bryophyllum pinnatum in mice. Afr J Biomed Res 2006;9:101-7.
Almeida AP, Da Silva SA, Souza ML, Lima LM, Rossi-Bergmann B, de Moraes VL, et al. Isolation and chemicals analisis of a fatty acid fraction of Kalanchoe pinnata with a potent lymphocyte suppressive activity. Planta Medica 2000;66:134-7.
Rossi-Bergmann B, Costa SS, Borges MB, da Silva SA, Noleto GR, Souza ML, et al. Immunosuppressive effect of the aqueous extract of Kalanchoe pinnata in mice. Phytothera Res 1994;8:399-402.
Okwu DE. Nigerian medicinal plant 11. Med Aromatic Plant Sci Biotechnol 2007;1:97-102.
Okwu DE. Evaluation of the chemical composition of indigenous spices of Southeastern Nigeria. Glob J Pure Appl Sci 2001;7:455-9.
Ofokansi KC, Esimone CO, Anele CK. Evaluation of the in vitro combined antibacterial effect of the leaf extracts of Bryophyllum pinnatum (Fam: Crassulaceae) and Ocimum gratissimum (Fam: Labiatae). Plant Prod Res J 2005;9:23-7.
Pal , Nag AK, Chaudhari N. Anti-inflammatory action of Bryophyllum pinnatum leaf extract. Fitoterapia 1990;61:527-33.
Ojewole JA. Antinociceptive, anti-inflammatory and antidiabetic effects of Bryophyllum pinnatum (Crassulaceae) leaf aqueous extract. J Ethno Pharm 2005;99:13-9.
Okwu DE, Okwu ME. Chemical composition of Spondia mombin (Linn) plant parts. J Sustain Agric Environ 2004;6:140-7.
Hunt , Groff IL, Holbrook J. Principles and Chemical Practice. New York: John Wiley and Sons; 1980. p. 459-62.
Okwu DE. Nigerian medicinal plant 11. Med Aromatic Plant Sci Biotechnol 2007;1:97-102.
Pal , Nag AK, Chaudhari N. Anti-inflammatory action of Bryophyllum pinnatum leaf extract. Fitoterapia 1990;61:527-33.
Sharma A, Bhot M, Chandra N. Protein profiling of Bryophyllum pinnatum (lam.) Kurz. leaf. Int J Pharm Pharm Sci 2014;6:496-7.
Akpantah AO, Obeten K, Edung ES, Eluwa AM. The effect of ethanolic extract of Bryophyllum pinnatum on the micro anatomy of the testes of adult males wister rats. Eur J Biol Med Sci Res 2014:2:37-44.
G. rappas Bryopyllum pinnatum Poisoning of Cattel. Aust Vet J 1995;72:425-7. Available from: http://www.findmeacure.com/2009/03/25/kalanchoe-pinnata.
Reppas GP. Bryophyllum pinnatum poisoning of cattle. Aust Vet J 1995;72:425-7.
Alabi DA, Jimoh OA, Amusa NA. Fungitoxic and phytotoxic effect of Vernonia amygdalina (L), Bryophyllum pinnatum Kurz Ocimum gratissimum (Closium) L. and Eucalyptna globules (Caliptos) Labill water extracts on cowpea and cowpea seedling pathogens in Ago Iwoye, South Western Nigeria. World J Agric Sci 2005;1:70-5.
Available from: http://www.homeremediess.comMedicinal plants and their uses
Majaz QA, Tatiya AU, Khurshid M, Nazim S. The miracle plant (Kalanchoe pinnata): A photochemical and pharmacological review. Int J Res Ayurveda Pharm 2011;2:1478-82.
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