Insilico interaction analysis of herbal bioactive molecules with Penicillin binding protein in staphylococcus aureus

Authors

  • Florida Tilton Biozone research Technologies Pvt. Ltd.
  • RANJITH KUMAR M Asan Memorial College of Arts & Science, Chennai
  • JEYANTHI V Asan Memorial College of Arts & Science, Chennai
  • LAKSHMI PRIYA K Biozone research Technologies Pvt. Ltd.

Abstract

Staphylococcus aureus is an opportunistic bacterial pathogen associated with asymptomatic colonization of the skin and mucosal surfaces of normal humans. Staphylococcus aureus isolates are often multidrug resistant. Antibiotics resistant Staphylococcus aureus is an emerging concern in the medical field. Due to their increasing resistance to numerous antibiotics, screening for alternate compound is required. Penicillin binding protein (PBP) was considered as an essential drug target for inhibiting bacterial growth. Molecular docking studies were performed to identify the lead molecule against Penicillin binding protein. Interaction of PBP with the plant derived compounds indicates the effective interaction of rosmarinic acid with highest fitness score and maximum number of hydrogen bonds (h-bonds). The study concludes that rosmarinic acid may be effective as an inhibitor for PBP and hence, can be regarded as a potential drug candidate for treating β-lactam resistant Staphylococcus aureus

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Author Biographies

Florida Tilton, Biozone research Technologies Pvt. Ltd.

Managing Director

Biozone research Technologies Pvt. Ltd.

RANJITH KUMAR M, Asan Memorial College of Arts & Science, Chennai

Department of Microbiology

 

JEYANTHI V, Asan Memorial College of Arts & Science, Chennai

Department of Microbiology

LAKSHMI PRIYA K, Biozone research Technologies Pvt. Ltd.

Bioinformatics

Head Scientific operations

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Published

01-03-2016

How to Cite

Tilton, F., R. K. . M, J. . V, and L. P. . K. “Insilico Interaction Analysis of Herbal Bioactive Molecules With Penicillin Binding Protein in Staphylococcus Aureus”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 2, Mar. 2016, pp. 44-47, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/3165.

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Original Article(s)