ROLE OF PROPHYLACTIC GATIFLOXACIN IN LAPAROSCOPIC CHOLECYSTECTOMY – A COMPARATIVE STUDY WITH CEFTRIAXONE

Authors

  • Anjna Department of Surgery, Government Medical College, Patiala, Punjab, India.
  • Tanveer Singh Kundra Department of Anaesthesiology, Government Medical College, Patiala, Punjab, India, https://orcid.org/0000-0003-0701-1637
  • Jaspreet Kaur Department of Anaesthesiology, Government Medical College, Patiala, Punjab, India,
  • Lalit Kumar Garg Department of Anaesthesiology, Shrimann Hospital, Jalandhar, Punjab, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i7.44481

Keywords:

prophylactic antibiotic, gatifloxacin, ceftriaxone

Abstract

Objectives: The objective of this study was to evaluate and compare the effectiveness of gatifloxacin and ceftriaxone as prophylactic antibiotic in elective clean surgical procedures.

Methods: Sixty patients, undergoing laparoscopic cholecystectomy, were recruited consecutively and divided into two groups, that is, Group A and Group B of 30 patients each. In Group A, a pre-operative dose of injection ceftriaxone 1 g was administered intravenously half an hour before induction of anesthesia and second dose was given 12 h postoperatively. In Group B, pre-operative dose of tablet Gatifloxacin 400 mg was administered night before operation and another tablet postoperatively when the patient started orally in the evening. If not accepting orally then single intravenous infusion of Gatifloxacin was given in the evening.

Results: In Group A, one patient (3.33%) had grade 1 and two patients (6.66%) had grade 2 infection. Similarly in Group B, one patient (3.33%) had grade 1 and two patients (6.66%) had grade 2 infection. None of the patients in both the groups had severe post-operative wound infection (grade 3 and grade 4).

Conclusion: Prophylactic gatifloxacin is non-inferior to the “current gold standard ceftriaxone” as far as effectiveness of the drug is concerned. In addition, it had a similar side effect profile and was equally safe as a prophylactic antibiotic in preventing wound infection following routine elective laparoscopic cholecystectomy.

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Author Biographies

Anjna, Department of Surgery, Government Medical College, Patiala, Punjab, India.

Assistant Professor

Department of Surgery

Tanveer Singh Kundra, Department of Anaesthesiology, Government Medical College, Patiala, Punjab, India,

Assistant Professor

Department of Anaesthesia

Jaspreet Kaur, Department of Anaesthesiology, Government Medical College, Patiala, Punjab, India,

Assistant Professor

Department of Anaesthesia

References

Nicholas RL. Prophylaxis for abdominal surgery. Rev Infect Dis 1981;1:76-82.

Feliciano DV, Gerntry LO, Carmel CG, Burch JM, Mattox KL, Cruse PA, et al. Single agent cephalosporin prophylaxis for penetrating abdominal trauma. Am J Surg 1986;6:674-81.

Gilbert DN, Bull NY. Current status of antibiotic prophylaxis in surgical patients. Bull N Y Acad Med 1984;60:340-57. PMID 6426566

Kaufman Z, Dinbar A. Single dose prophylaxis in elective cholecystectomy. A prospective, double-blind randomized study. Am J Surg 1986;152:513-6. doi: 10.1016/0002-9610(86)90218-7, PMID 3777330

Chandrashekhar C, Seenu V, Misra MC, Rattan A, Kapur BM, Singh R. Risk factors for wound infection following elective cholecystectomy. Trop Gastroenterol 1996;17:230-2. PMID 9094866.

Lippert H, Gastinger J. Antimicrobial prophylaxis in laparoscopic and conventional cholecystectomy-conclusions of a large prospective multicenter quality assurance study in Germany. Chemotherapy 1998;44:355-63. doi: 10.1159/000007135, PMID 9732152

Chodak GW, Plaut ME. Use of systemic antibiotic prophylaxis in surgery-a clinical review. Arch Surg 1977;112:326.

Stone HH, Hester TR. Incisional and peritoneal infection after emergency colectomy. Ann Surg 1973;177:669-78. doi: 10.1097/00000658- 197306000-00005, PMID 4350745

Stone HH, Hooper CA, Kolb LD, Geheber CE, Dawkins EJ. Antibiotic prophylaxis in gastric, biliary and colonic surgery. Ann Surg 1976;184:443-52. doi: 10.1097/00000658-197610000-00007, PMID 827989

Pollock AV. Surgical wound sepsis. Lancet 1979;1:1283-6. doi: 10.1016/s0140-6736(79)92239-6, PMID 87737

Haley RW, Culver DH, White JW, Morgan WM, Emori TG. The nationwide nosocomial infection rate: A new need for vital ststistics. Am J Epidemiol 1985;121:159-67. doi: 10.1093/oxfordjournals.aje. a113988, PMID 4014113

Brown RB, Bradley S, Opitz E, Cipriani D, Pieczarka R, Sands M. Surgical wound infection documented after hospital discharge. Am J Infect Control 1987;15:54-8. doi: 10.1016/0196-6553(87)90002-2, PMID 3646857

Brogden RN, Ward A. Ceftriaxone-a reappraisal of its antibacterial activity and pharmacokinetics properties, and an update on its therapeutic use with particular reference to once-daily admistration. Drugs 1988;35:604-45. doi: 10.2165/00003495-198835060-00002, PMID 3048974

Colizza S, Rossi S, Picardi B, Carnuccio P, Pollicita S, Rodio F, et al. Surgical infections after laparoscopic cholecystectomy: Ceftriaxone vsceftazidimeantibiotic prophylaxis. A prospective study. Chir Ital 2004;56:397-402. PMID 15287637

Kellum JM Jr., Gargano S, Gorbach SL, Talcof C, Curtis LE, Weiner B, et al. Antibiotic prophylaxis in high-risk biliary operations: Multicenter trial of single preoperative ceftriaxone versus multidose cefazolin. Am J Surg 1984;148:15-8. PMID 6091474

Park-Wyllie LY, Juurlink DN, Kopp A, Shah BR, Stukel TA, Stumpo C, et al. Outpatient gatifloxacin therapy and dysglycemia in older adults. N Engl J Med 2006;354:1352-61. doi: 10.1056/NEJMoa055191, PMID 16510739

Published

07-07-2022

How to Cite

Anjna, T. S. Kundra, J. Kaur, and L. K. Garg. “ROLE OF PROPHYLACTIC GATIFLOXACIN IN LAPAROSCOPIC CHOLECYSTECTOMY – A COMPARATIVE STUDY WITH CEFTRIAXONE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 7, July 2022, pp. 97-99, doi:10.22159/ajpcr.2022.v15i7.44481.

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