INTEGRATING ARTIFICIAL INTELLIGENCE IN DISEASE DIAGNOSIS, TREATMENT, AND FORMULATION DEVELOPMENT: A REVIEW
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i11.48193Keywords:
Artificial Intelligence, Disease diagnosis, Health-care digitization, Machine learningAbstract
Artificial intelligence (AI) is rapidly advancing and significantly impacting clinical care and treatment. Machine learning and deep learning, as core digital AI technologies, are being extensively applied to support diagnosis and treatment. With the progress of digital health-care technologies such as AI, bioprinting, robotics, and nanotechnology, the health-care landscape is transforming. Digitization in health-care offers various opportunities, including reducing human error rates, improving clinical outcomes, and monitoring longitudinal data. AI techniques, ranging from learning algorithms to deep learning, play a critical role in several health-care domains, such as the development of new health-care systems, improvement of patient information and records, and treatment of various ailments. AI has emerged as a powerful scientific tool, capable of processing and analyzing vast amounts of data to support decision-making. Numerous studies have demonstrated that AI can perform on par with or outperform humans in crucial medical tasks, including disease detection. However, despite its potential to revolutionize health care, ethical considerations must be carefully addressed before implementing AI systems and making informed decisions about their usage. Researchers have utilized various AI-based approaches, including deep and machine learning models, to identify diseases that require early diagnosis, such as skin, liver, heart, and Alzheimer’s diseases. Consequently, related work presents different methods for disease diagnosis along with their respective levels of accuracy, including the Boltzmann machine, K nearest neighbor, support vector machine, decision tree, logistic regression, fuzzy logic, and artificial neural network. While AI holds immense promise, it is likely to take decades before it completely replaces humans in various medical operations.
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Woldaregay AZ, Årsand E, Walderhaug S, Albers D, Mamykina L, Botsis T, et al. Data-driven modeling and prediction of blood glucose dynamics: Machine learning applications in Type 1 diabetes. Artif Intell Med 2019;98:109-34. doi: 10.1016/j.artmed.2019.07.007
Musleh MM, Alajrami E, Khalil AJ, Abu-Nasser BS, Barhoom AM, Naser SA. Predicting liver patients using artificial neural network. Int J Acad Inf Syst Res 2019;3:1-11.
Dabowsa NI, Amaitik NM, Maatuk AM, Aljawarneh SA. A Hybrid Intelligent System for Skin Disease Diagnosis. In: IEEE International Conference on Engineering and Technology; 2017. p. 1-6.
Bhatt VK, Pal VK. An Intelligent System for Diagnosing Thyroid Disease in Pregnant Ladies through Artificial Neural Network. In: International Conference on Advances in Engineering Science Management and Technology (ICAESMT); 2019.
Uddin M, Wang Y, Woodbury-Smith M. Artificial intelligence for precision medicine in neurodevelopmental disorders. NPJ Digit Med 2019;2:112. doi:10.1038/s41746-019-0191-0
Yıldırım O, Pławiak P, Tan RS, Acharya UR. Arrhythmia detection using deep convolutional neural network with long duration ECG signals. Comput Biol Med 2018;102:411-20. doi: 10.1016/j. compbiomed.2018.09.009
Skaane P, Bandos AI, Gullien R, Eben EB, Ekseth U, Haakenaasen U, et al. Comparison of digital mammography alone and digital mammography plus tomosynthesis in a population-based screening program. Radiology 2013;267:47-56. doi: 10.1148/radiol.12121373
Alazzam MB, Alassery F, Almulihi A. A novel smart healthcare monitoring system using machine learning and the Internet of Things. Wirel Commun Mobile Comput 2021;2021:5078799. doi: 10.1155/2021/5078799
Al-Kahtani MS, Khan F, Taekeun W. Application of internet of things and sensors in healthcare. Sensors 2022;22:5738. doi: 10.3390/ s22155738
Ijaz MF, Alfian G, Syafrudin M, Rhee J. Hybrid prediction model for Type 2 diabetes and hypertension using DBSCAN-based outlier detection, synthetic minority over sampling technique (SMOTE), and random forest. Appl Sci 2018;8:1325. doi: 10.3390/app8081325
Shabut AM, Tania MH, Lwin KT, Evans BA, Yusof NA, Abu- Hassan KJ, et al. An intelligent mobile-enabled expert system for tuberculosis disease diagnosis in real time. Expert Syst Appl 2018;114:65-77. doi: 10.1016/j.eswa.2018.07.014
Gupta R, Srivastava D, Sahu M, Tiwari S, Ambasta RK, Kumar P. Artificial intelligence to deep learning: Machine intelligence approach for drug discovery. Mol Divers 2021;25:1315-60. doi: 10.1007/s11030- 021-10217-3
Loucks J, Davenport T, Schatsky D. State of AI in the Enterprise. London: Deloitte Insights Report; 2018.
Graham S, Depp C, Lee EE, Nebeker C, Tu X, Kim HC, et al. Artificial intelligence for mental health and mental illnesses: An overview. Curr Psychiatry Rep 2019;21:116. doi: 10.1007/s11920-019-1094-0
Rezaee K, Khosravi MR, Jabari M, Hesari S, Anari MS, Aghaei F. Graph convolutional network‐based deep feature learning for cardiovascular disease recognition from heart sound signals. Int J Intel Syst 2022;37:11250-74.
Lee SI, Celik S, Logsdon BA, Lundberg SM, Martins TJ, Oehler VG, et al. A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia. Nat Commun 2018;9:42. doi: 10.1038/s41467-017-02465-5
Wani SU, Khan NA, Thakur G, Gautam SP, Ali M, Alam P, et al. Utilization of artificial intelligence in disease prevention: Diagnosis, treatment, and implications for the healthcare workforce. Healthcare (Basel) 2022;10:608. doi: 10.3390/healthcare10040608
Fakoor R, Ladhak F, Nazi A, Huber M. Using Deep Learning to Enhance Cancer Diagnosis and Classification. In: Proceedings of the International Conference on Machine Learning; 2013. p. 3937-49.
Vial A, Stirling D, Field M, Ros M, Ritz C, Carolan M, et al. The role of deep learning and radiomic feature extraction in cancer-specific predictive modelling: A review. Transl Cancer Res 2018;7:803-16. doi: 10.21037/tcr.2018.05.02
Pourhomayoun M, Shakibi M. Predicting mortality risk in patients with COVID-19 using machine learning to help medical decision-making. Smart Health 2021;20:100178. doi: 10.1016/j.smhl.2020.100178
Ho TS, Weng TC, Wang JD, Han HC, Cheng HC, Yang CC, et al. Comparing machine learning with case-control models to identify confirmed dengue cases. PLoS Negl Trop Dis 2020;14:e0008843. doi: 10.1371/journal.pntd.0008843
Weng SF, Reps J, Kai J, Garibaldi JM, Qureshi N. Can machine-learning improve cardiovascular risk prediction using routine clinical data? PLoS One 2017;12:e0174944. doi: 10.1371/journal.pone.0174944
Chiu HY, Hwang CK, Chen SY, Shih FY, Han HC, King CC, et al. Machine learning for emerging infectious disease field responses. Sci Rep 2022;12:328. doi: 10.1038/s41598-021-03687-w
Alfred R, Obit JH. The roles of machine learning methods in limiting the spread of deadly diseases: A systematic review. Heliyon 2021;7:e07371. doi: 10.1016/j.heliyon.2021.e07371
He CG, Li JW, Zu B, Liu WJ, Qiu HN, Bai XJ. Sericite 40Ar/39Ar and zircon U-Pb dating of the Liziyuan gold deposit, West Qinling orogen, central China: Implications for ore genesis and tectonic setting. Ore Geol Rev 2021;139:104531.
Saba T, Abunadi I, Shahzad MN, Khan AR. Machine learning techniques to detect and forecast the daily total COVID‐19 infected and deaths cases under different lockdown types. Microsc Res Tech 2021;84:1462-74. doi: 10.1002/jemt.23702
Aldahiri A, Alrashed B, Hussain W. Trends in using IoT with machine learning in health prediction system. Forecasting 2021;3:181-207. doi:10.3390/forecast3010012
Agbehadji IE, Awuzie BO, Ngowi AB, Millham RC. Review of big data analytics, artificial intelligence and nature-inspired computing models towards accurate detection of COVID-19 pandemic cases and contact tracing. Int J Environ Res Public Health 2020;17:5330. doi: 10.3390/ ijerph17155330
Kumar Y, Koul A, Singla R, Ijaz MF. Artificial intelligence in disease diagnosis: A systematic literature review, synthesizing framework and future research agenda. J Ambient Intell Humaniz Comput 2022; 14:1- 28. doi: 10.1007/s12652-021-03612-z
Lotsch J, Kringel D, Ultsch A. Explainable artificial intelligence (XAI) in biomedicine: Making AI decisions trustworthy for physicians and patients. BioMedInformatics 2022;2:1-7. doi: 10.3390/ biomedinformatics2010001
Linardatos P, Papastefanopoulos V, Kotsiantis S. Explainable AI: A review of machine learning interpretability methods. Entropy (Basel) 2020;23:18. doi: 10.3390/e23010018
Lipton ZC. The mythos of model interpretability: In machine learning, the concept of interpretability is both important and slippery. Queue 2018;16:31-57. doi: 10.1145/3236386.3241340
Doshi-Velez F, Kim B. Towards a rigorous science of interpretable machine learning. arXiv preprint arXiv:1702.08608; 2017.
Tocchetti A, Brambilla M. The role of human knowledge in explainable AI. Data 2022;7:93. doi: 10.3390/data7070093
Ashiagbor G, Asare-Ansah AO, Amoah EB, Asante WA, Mensah YA. Assessment of machine learning classifiers in mapping the cocoa forest mosaic landscape of Ghana. Sci Afr 2023;20:e01718.
Datta A, Matlock MK, Le Dang N, Moulin T, Woeltje KF, Yanik EL, et al. “Black box” to “conversational” machine learning: Ondansetron reduces risk of hospital-acquired venous thromboembolism. IEEE J Biomed Health Inform 2020;25:2204-14.
Datta A, Flynn NR, Barnette DA, Woeltje KF, Miller GP, Swamidass SJ. Machine learning liver-injuring drug interactions with non-steroidal anti-inflammatory drugs (NSAIDs) from a retrospective electronic health record (EHR) cohort. PLoS Comput Biol 2021;17:e1009053. doi: 10.1371/journal.pcbi.1009053
Shamshirband S, Fathi M, Dehzangi A, Chronopoulos AT, Alinejad- Rokny H. A review on deep learning approaches in healthcare systems: Taxonomies, challenges, and open issues. J Biomed Inform 2021;113:103627. doi: 10.1016/j.jbi.2020.103627
Naser MZ. An engineer’s guide to eXplainable artificial intelligence and interpretable machine learning: Navigating causality, forced goodness, and the false perception of inference. Autom Constr 2021;129:103821. doi: 10.1016/j.autcon.2021.103821
Dikshit A, Pradhan B. Interpretable and explainable AI (XAI) model for spatial drought prediction. Sci Total Environ 2021;801:149797. doi: 10.1016/j.scitotenv.2021.149797
Minaee S, Kafieh R, Sonka M, Yazdani S, Soufi GJ. Deep-COVID: Predicting COVID-19 from chest X-ray images using deep transfer learning. Med Image Anal 2020;65:101794. doi: 10.1016/j. media.2020.101794
Kumar Y, Singla R. Federated learning systems for healthcare: Perspective and recent progress. In: Federated Learning Systems: Towards Next-Generation AI. Berlin: Springer; 2021. p. 141-56. doi:10.1007/978-3-030-70604-3_6
Tengnah MA, Sooklall R, Nagowah SD. A predictive model for hypertension diagnosis using machine learning techniques. In: Telemedicine Technologies. United States: Academic Press; 2019. p. 139-52.
Jo T, Nho K, Saykin AJ. Deep learning in Alzheimer’s disease: Diagnostic classification and prognostic prediction using neuroimaging data. Front Aging Neurosci 2019;11:220. doi: 10.3389/fnagi.2019.00220
Chen J, Remulla D, Nguyen JH, Dua A, Liu Y, Dasgupta P, et al. Current status of artificial intelligence applications in urology and their potential to influence clinical practice. BJU Int 2019;124:567-77. doi: 10.1111/bju.14852
Nasser IM, Abu-Naser SS. Predicting tumor category using artificial neural networks. Int J Acad Health Med Res 2019;3:1-7.
Sarao V, Veritti D, Lanzetta P. Automated diabetic retinopathy detection with two different retinal imaging devices using artificial intelligence: A comparison study. Graefes Arch Clin Exp Ophthalmol 2020;258:2647-54. doi: 10.1007/s00417-020-04853-y
Keenan TD, Clemons TE, Domalpally A, Elman MJ, Havilio M, Agrón E, et al. Retinal specialist versus artificial intelligence detection of retinal fluid from OCT: Age-related eye disease study 2: 10-year follow-on study. Ophthalmology 2021;128:100-9. doi: 10.1016/j. ophtha.2020.06.038
Rajalakshmi R, Subashini R, Anjana RM, Mohan V. Automated diabetic retinopathy detection in smartphone-based fundus photography using artificial intelligence. Eye 2018;32:1138-44. doi: 10.1038/s41433-018- 0064-9
Bibault JE, Xing L. Screening for chronic obstructive pulmonary disease with artificial intelligence. Lancet Digit Health 2020;2:e216-7. doi: 10.1016/S2589-7500(20)30076-5
Chen Y, Sha M, Zhao X, Ma J, Ni H, Gao W, et al. Automated detection of pathologic white matter alterations in Alzheimer’s disease using combined diffusivity and kurtosis method. Psychiatry Res Neuroimaging 2017;264:35-45. doi: 10.1016/j.pscychresns.2017.04.004
Govindan B, Sabri MA, Hai A, Banat F, Haija MA. A review of advanced multifunctional magnetic nanostructures for cancer diagnosis and therapy integrated into an artificial intelligence approach. Pharmaceutics 2023;15:868. doi: 10.3390/pharmaceutics15030868
Mirbabaie M, Stieglitz S, Frick NR. Artificial intelligence in disease diagnostics: A critical review and classification on the current state of research guiding future direction. Health Technol 2021;11:693-731. doi: 10.1007/s12553-021-00555-5
Fukuda M, Inamoto K, Shibata N, Ariji Y, Yanashita Y, Kutsuna S, et al. Evaluation of an artificial intelligence system for detecting vertical root fracture on panoramic radiography. Oral Radiol 2020;36:337-43. doi: 10.1007/s11282-019-00409-x
Lei Y, Guo Y, Zhang Y, Cheung W. Information technology and service diversification: A cross-level study in different innovation environments. Inform Manag 2021;58:103432.
Yang L, Lu H, Wang S, Li M. Mobile internet use and multidimensional poverty: Evidence from a household survey in rural China. Soc Indic Res 2021;158:1065-86. doi: 10.1007/s11205-021-02736-1
Subrahmanya SV, Shetty DK, Patil V, Hameed BZ, Paul R, Smriti K, et al. The role of data science in healthcare advancements: Applications, benefits, and future prospects. Ir J Med Sci 2022;191:1473-83. doi: 10.1007/s11845-021-02730-z
Schoormann T, Strobel G, Möller F, Petrik D. Achieving Sustainability with Artificial Intelligence-a Survey of Information Systems Research. In: Proceedings of the 42nd International Conference on Information Systems (ICIS 2021); 2021.
Agamah FE, Mazandu GK, Hassan R, Bope CD, Thomford NE, Ghansah A, et al. Computational/in silico methods in drug target and lead prediction. Brief Bioinform 2020;21:1663-75. doi: 10.1093/bib/ bbz103
Nussinov R, Zhang M, Liu Y, Jang H. AlphaFold. Artificial intelligence (AI), and allostery. J Phys Chem B 2022;126:6372-83. doi: 10.1021/ acs.jpcb.2c04346
Zhang Y, Vass M, Shi D, Abualrous E, Chambers JM, Chopra N, et al. Benchmarking refined and unrefined AlphaFold2 structures for hit discovery. J Chem Inf Model 2023;63:1656-67. doi: 10.1021/acs. jcim.2c01219
Torrisi M, Pollastri G, Le Q. Deep learning methods in protein structure prediction. Comput Struct Biotechnol J 2020;18:1301-10. doi: 10.1016/j.csbj.2019.12.011
Kumar P, Bankapur S, Patil N. An enhanced protein secondary structure prediction using deep learning framework on hybrid profile-based features. Appl Soft Comput 2020;86:105926. doi: 10.1016/j. asoc.2019.105926
Bai Q, Tan S, Xu T, Liu H, Huang J, Yao X. MolAICal: A soft tool for 3D drug design of protein targets by artificial intelligence and classical algorithm. Brief Bioinform 2021;22:bbaa161. doi: 10.1093/ bib/bbaa161
Popova M, Isayev O, Tropsha A. Deep reinforcement learning for de novo drug design. Sci Adv 2018;4:eaap7885. doi: 10.1126/sciadv. aap7885
Segler MH, Preuss M, Waller MP. Planning chemical syntheses with deep neural networks and symbolic AI. Nature 2018;555:604-10. doi: 10.1038/nature25978
De S, Dey S, Bhatia S, Bhattacharyya S. An introduction to data mining in social networks. In: Advanced Data Mining Tools and Methods for Social Computing. United States: Academic Press; 2022. p. 1-25.
Albalawi R, Yeap TH, Benyoucef M. Using topic modeling methods for short-text data: A comparative analysis. Front Artif Intell 2020;3:42. doi: 10.3389/frai.2020.00042
Ikram R, Psutka R, Carter A, Priest P. An outbreak of multi-drug resistant Escherichia coli urinary tract infection in an elderly population: A case-control study of risk factors. BMC Infect Dis 2015;15:224. doi: 10.1186/s12879-015-0974-0
Djenouri Y, Belhadi A, Yazidi A, Srivastava G, Lin JC. Artificial intelligence of medical things for disease detection using ensemble deep learning and attention mechanism. Expert Syst 2022; ???:e13093. doi: 10.1111/exsy.13093
Amann J, Blasimme A, Vayena E, Frey D, Madai VI, Precise4Q Consortium. Explainability for artificial intelligence in healthcare: A multidisciplinary perspective. BMC Med Inform Decis Mak 2020;20:310. doi: 10.1186/s12911-020-01332-6
Davenport T, Kalakota R. The potential for artificial intelligence in healthcare. Future Healthc J 2019;6:94-98. doi: 10.7861/ futurehosp.6-2-94
Farhang-Sardroodi S, Ghaemi MS, Craig M, Ooi HK, Heffernan JM. A machine learning approach to differentiate between COVID-19 and influenza infection using synthetic infection and immune response data. Math Biosci Eng 2022;19:5813-31. doi: 10.3934/mbe.2022272
Hosny A, Parmar C, Quackenbush J, Schwartz LH, Aerts HJ. Artificial intelligence in radiology. Nat Rev Cancer 2018;18:500-10. doi: 10.1038/s41568-018-0016-5
Gudigar A, Raghavendra U, Nayak S, Ooi CP, Chan WY, Gangavarapu MR, et al. Role of artificial intelligence in COVID-19 detection. Sensors (Basel) 2021;21:8045. doi: 10.3390/s21238045
Naikoo GA, Arshad F, Hassan IU, Awan T, Salim H, Pedram MZ, et al. Nanomaterials‐based sensors for the detection of COVID‐19: A review. Bioeng Transl Med 2022;7:e10305. doi: 10.1002/btm2.10305
Jia LL, Zhao JX, Pan NN, Shi LY, Zhao LP, Tian JH, et al. Artificial intelligence model on chest imaging to diagnose COVID-19 and other pneumonias: A systematic review and meta-analysis. Eur J Radiol Open 2022;9:100438. doi: 10.1016/j.ejro.2022.100438
Belle A, Thiagarajan R, Soroushmehr SM, Navidi F, Beard DA, Najarian K. Big data analytics in healthcare. Biomed Res Int 2015;2015:370194. doi: 10.1155/2015/370194
Shaikh FJ, Rao DS. Prediction of cancer disease using machine learning approach. Mater Today Proc 2022;50:40-7.
Botlagunta M, Botlagunta MD, Myneni MB, Lakshmi D, Nayyar A, Gullapalli JS, et al. Classification and diagnostic prediction of breast cancer metastasis on clinical data using machine learning algorithms. Sci Rep 2023;13:485. doi: 10.1038/s41598-023-27548-w
Ahmed AA, Abouzid M, Kaczmarek E. Deep learning approaches in histopathology. Cancers (Basel) 2022;14:5264. doi: 10.3390/ cancers14215264
Thakare A, Bhende M, Tesema M, Dighriri M, Bhavani R, Mahmoud A. An intelligent classification system for cancer detection based on DNA methylation using ML and semantic knowledge in healthcare. Comput Intell Neurosci 2022;2022:4334852. doi:10.1155/2022/4334852
Koul A, Bawa RK, Kumar Y. Artificial intelligence techniques to predict the airway disorders illness: A systematic review. Arch Comput Methods Eng 2023;30:831-64. doi: 10.1007/s11831-022-09818-4
Aggarwal K, Mijwil MM, Al-Mistarehi AH, Alomari S, Gök M, Alaabdin AM, et al. Has the future started? The current growth of artificial intelligence, machine learning, and deep learning. Arch Comput Methods Eng 2023;30:831-64.
Sharma M, Savage C, Nair M, Larsson I, Svedberg P, Nygren JM. Artificial intelligence applications in health care practice: Scoping review. J Med Internet Res 2022;24:e40238. doi: 10.2196/40238
Bohr A, Memarzadeh K. The rise of artificial intelligence in healthcare applications. In: Artificial Intelligence Healthcare. United States: Academic Press; 2020. p. 25-60. doi: 10.1016/B978-0-12-818438- 7.00002-2
He J, Baxter SL, Xu J, Xu J, Zhou X, Zhang K. The practical implementation of artificial intelligence technologies in medicine. Nat Med 2019;25:30-6. doi: 10.1038/s41591-018-0307-0
Ghaffar Nia N, Kaplanoglu E, Nasab A. Evaluation of artificial intelligence techniques in disease diagnosis and prediction. Discov Artif Intell 2023;3:5. doi: 10.1007/s44163-023-00049-5
Olatunji SO, Alsheikh N, Alnajrani L, Alanazy A, Almusairii M, Alshammasi S, et al. Comprehensible machine-learning-based models for the pre-emptive diagnosis of multiple sclerosis using clinical data: A retrospective study in the eastern province of Saudi Arabia. Int J Environ Res Public Health 2023;20:4261. doi: 10.3390/ijerph20054261
Javaid M, Haleem A, Singh RP, Suman R, Rab S. Significance of machine learning in healthcare: Features, pillars, and applications. Int J Intel Syst 2022;3:58-73. doi: 10.1016/j.ijin.2022.05.002
Anderson J, Rainie L, Luchsinger A. Artificial Intelligence and the Future of Humans. Vol. 10. United States: Pew Research Center; 2018.
Mollmann NR, Mirbabaie M, Stieglitz S. Is it alright to use artificial intelligence in digital health? A systematic literature review on ethical considerations. Health Informatics J 2021;27:1460. doi: 10.1177/14604582211052391
Basu K, Sinha R, Ong A, Basu T. Artificial intelligence: How is it changing medical sciences and its future? Indian J Dermatol 2020;65:365-70. doi: 10.4103/ijd.IJD_421_20
Toorajipour R, Sohrabpour V, Nazarpour A, Oghazi P, Fischl M. Artificial intelligence in supply chain management: A systematic literature review. J Bus Res 2021;122:502-17. doi: 10.1016/j. jbusres.2020.09.009
Arrieta AB, Díaz-Rodríguez N, Del Ser J, Bennetot A, Tabik S, Barbado A, et al. Explainable artificial intelligence (XAI): Concepts, taxonomies, opportunities and challenges toward responsible AI. Inf Fusion 2020;58:115. doi: 10.1016/J.INFFUS.2019.12.012
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