GREEN METHOD FOR ACETAMINOPHEN AND IBUPROFEN SIMULTANEOUS ASSAY IN THE COMBINATION TABLET USING FTIR
DOI:
https://doi.org/10.22159/ijap.2018v10i3.23034Keywords:
FTIR, Green method, Acetaminophen, Ibuprofen, AssayAbstract
Objective: The purpose of this study was to develop a green method for assay the tablet consists of a combination of acetaminophen (ACT)-ibuprofen (IBU). FTIR (Fourier Transform Infrared Spectroscopy), which is commonly used for qualitative analysis, was developed to measure the tablet contents, directly and quantitatively.
Methods: Standard for ACT and IBU was respectively mixed with KBr crystal in varied and measured using FTIR. The transmission spectrum yielded later was converted into its absorbance-derivatized forms which then a calibration curve was composed using the data. Once validated, the analytical method was conducted on samples of the branded ACT-IBU combination tablet.
Results: ACT had a specific wavenumber of a group N-H stretch, meanwhile IBU was represented by the C = O spectrum. These peaks then used for quantitative calculation basis levels respectively. The limits of detection and quantitation of ACT consecutively were % w/w and  w/w and IBU were % w/w and  w/w. Next; the method was carried out successfully to evaluate the content of sample tablet from the market.
Conclusion: The analytical method of ACT-IBU was proven applicable and suitable for the quantitative purpose. The method shows meet with the expectation such as simple and easy to perform and reduce the use of solvents.
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References
Hardman JG, Limbird LE, Gilman AG. Goodman and Gilman’s the pharmacological basis of therapeutics. 10th ed. New York, USA: McGraw-Hill; 2001.
Hay AD, Redmond NM, Montgomery AA, Fletcher M, Hollinghurst S, Peters TJ. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. Br Med J 2008;337:729.
Brune K, Hinz B. Paracetamol, ibuprofen, or a combination of both drugs against knee pain: an excellent new randomised clinical trial answers old questions and suggests new therapeutic recommendations. Ann Rheum Dis 2011;70:1521–2.
IBU and Paracetamol 200 mg/500 mg tablets–summary of product characteristics. Reckitt Benckiser Healthcare (UK) Ltd. Available from: http://www.medicines.org.uk/emc/medicine/ 23871/SPC0000. [Last accessed on 10 Oct 2017].
Ministry of Health of the Republic of Indonesia: Pharmacopoeia Indonesia. 5th ed. Jakarta: Ministry of Health of the Republic of Indonesia; 2014.
British Pharmacopeia (BP). Vol. II. London: Her Majesty’s Stationary Office; 2001.
Battu PR, Reddy MS. RP-HPLC method for simultaneous estimation of paracetamol and Ibuprofen in tablets. Asian J Res Chem 2009;2:70-2.
Jahan S, Islam MJ, Begum R, Kayesh R, Rahman A. A study of method development, validation, and forced degradation for simultaneous quantification of paracetamol and ibuprofen in pharmaceutical dosage form by the RP-HPLC method. Anal Chem Insights 2014;9:75–81.
Lakka NS, Goswami N, Balakrishna P. Development and validation of an RP-HPLC for simultaneous determination of ibuprofen and paracetamol in solid dosage forms: application to dissolution studies. Int J Res Pharm Sci 2011;2:331–7.
Gnana RM, Geetha G, Sangaranarayanan A. Simultaneous, stability indicating method development and validation for related compounds of Ibuprofen and paracetamol tablets by RP-HPLC method. J Chromatogr Sep Tech 2012;3:3–8.
Tsvetkova BG, Pencheva IP, Zlatkov AB, Peikov PT. Development and validation of RP-HPLC method for simultaneous determination of paracetamol and ibuprofen in fixed dose combinations. Int J Pharm Sci Rev Res 2012;16:13–6.
Maslarska V, Tencheva J. Simultaneous determination and validation of paracetamol and codeine phosphate in pharmaceutical preparation by RP-HPLC. Int J Pharm Pharm Sci 2012;5:417-9.
Namies Ìnik J. Green analytical chemistry. J Separation Sci 2001;24:151-3.
Gunzler H, Gremlich HU. Infrared spectroscopy: an introduction. Berlin: Wiley-VCH; 2002.
Sahoo S, Chakraborti CK, Mishra SC, Nanda UN, Naik S. FTIR and XRD investigations of some fluoroquinolones. Int J Pharm Pharm Sci 2011;3:165-¬70.
Bhongade B, Talath S, Dhaneswar SA. a Validated method for the quantitation of ciprofloxacin hydrochloride using diffuse reflectance infrared fourier transform spectroscopy. Int J Spec 2014:1-4. http://dx.doi.org/10.1155/2014/294612
Rakesh P, Charmi P, Rajesh P. Quantitative analytical applications of FTIR spectroscopy in pharmaceutical applied areas. J Adv Pharm Ed Res 2014;4:145-57.
Hoang VD, Ly DTH, Tho NH, Nguyen HMT. UV Spectro-photometric simultaneous determination of paracetamol and ibuprofen in combined tablets by derivative and wavelet transforms. Sci World J 2014. http://dx.doi.org/ 10.1155/ 2014/313609.
Lotfy HM. Absorbance subtraction and amplitude modulation as novel spectrophotometric methods for the analysis of binary mixtures. Int J Pharm Pharm Sci 2013;6:735-41.
Khveshchuk PF, Rudakova AV. Use of derivative spectrofluorometry in the analysis of ajmaline in drug dosage forms. Pharm Chem J 1995;29:796–8.
Nugrahani I, Musaddah M. Development and validation analysis of acyclovir tablet content determination method using FTIR. Int J Appl Pharm 2016;8:43-7.
Nugrahani I, Kartini C. Determination of thiamine HCl (vitamin b1) and pyridoxine HCl (vitamin b6) content in tablet by FTIR. Int J Pharm Pharm Sci 2016;8:257-64.
International Conference of Harmonization (ICH). Q2 Validation of Analytical Procedures: Text and methodology international conference on harmonization of technical requirements for registration of pharmaceutical for human use, Canada: ICH Harmonized Tripartite Guideline; 2005.
Ahuja S, Dong M. Handbook of pharmaceutical analysis by HPLC. North Carolina: Elsevier Academic Press; 2005. p. 191-200.
United States Pharmacopeia (USP) 34 (NF 29), Chapter<621>. Edition; 2011.
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