FORMULATION AND EVALUATION OF PHYTOSOME LOTION FROM NOTHOPANAX SCUTELLARIUM LEAF EXTRACT FOR HAIR GROWTH

IKA AULIA RAHMI; ABDUL MUN’IM; MAHDI JUFRI

doi:10.22159/ijap.2021v13i6.42169

Authors

IKA AULIA RAHMI Graduate of Herbal Aesthetics, Faculty of Pharmacy, Universitas Indonesia
ABDUL MUN’IM Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Indonesia
MAHDI JUFRI Department of Pharmaceutical Technology and Drug Development, Faculty of Pharmacy, Universitas Indonesia

DOI:

https://doi.org/10.22159/ijap.2021v13i6.42169

Keywords:

Flavonoid, Mangkokan leaf, Nothopanax scutellarium, Phytosome, Hair growth activity

Abstract

Objective: The purpose of this study was to formulate a phytosome lotion from Mangkokan leaf using green solvent extraction.

Methods: Ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate, combined with microwave-assisted extraction, was used to obtain flavonoid compounds. Mangkokan leaf extract was formulated into a phytosome with three different ratios of phospholipon (1:0.5), (1:1), and (1:2). Three phytosome formulas were analyzed to identify the best formula. The analysis included morphology, particle size, and zeta potential, entrapment efficiency, and spectrum analysis using an FTIR spectrophotometer. The formula which chosen was formulated into three lotion formulas with different concentration (20%; 25%; 30%) then, evaluated for physical stability, and hair growth activity test included hair length, weight, and diameter. Minoxidil and non-phytosome lotion were used as comparison. Data were analyzed using two-way ANOVA.

Results: The FTIR of phytosome was confirmed a complex formation of extract and phospholipon. The phytosome morphology was displayed irregular spherical vesicles. Phytosome with the ratio of phospholipon (1:0.5) was formulated into lotion because has a smaller particle size (289 nm), and higher entrapment efficiency (99.76%±0.24) than others. Phytosome lotions displayed higher activity than 2% minoxidil (p = 0.0001). Phytosome lotion (30%) thus showed the highest efficacy for hair length, weight and diameter.

Conclusion: Mangkokan leaf that extracted using 1-butyl-3-methylimidazolium tetrafluoroborate solvent combined with microwave-assisted extraction then formulated into phytosome lotion has higher activity than 2% minoxidil. Lotion that contains 30% mangkokan leaf phytosome was showed the highest efficacy.

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