NOVEL APPROACHES IN OCULAR DRUG DELIVERY-A REVOLUTION

AYUSHI KAUSHIK; RUPA MAZUMDER; SWARUPANJALI PADHI; AVIJIT MAZUMDER; RAJAT BUDHORI; MANORMA; SWARNALI DAS PAUL

doi:10.22159/ijap.2022v14i3.44045

Authors

AYUSHI KAUSHIK Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park-2, Institutional Area, Greater Noida, Uttar Pradesh 201306, India
RUPA MAZUMDER Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park-2, Institutional Area, Greater Noida, Uttar Pradesh 201306, India https://orcid.org/0000-0002-1888-548X
SWARUPANJALI PADHI Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park-2, Institutional Area, Greater Noida, Uttar Pradesh 201306, India https://orcid.org/0000-0003-2200-5542
AVIJIT MAZUMDER Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park-2, Institutional Area, Greater Noida, Uttar Pradesh 201306, India https://orcid.org/0000-0002-3053-8106
RAJAT BUDHORI Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park-2, Institutional Area, Greater Noida, Uttar Pradesh 201306, India
MANORMA Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park-2, Institutional Area, Greater Noida, Uttar Pradesh 201306, India https://orcid.org/0009-0005-4165-6035
SWARNALI DAS PAUL SSTC-SSGI-FPS, Bhilai, Chhattisgarh, 490020, India

DOI:

https://doi.org/10.22159/ijap.2022v14i3.44045

Keywords:

Ocular barriers, Novel delivery, Nanowafers, Cubosomes, Microneedles, Cell therapy, Implants

Abstract

Conveying the therapeutic agent to the human eye has been a struggling task for formulators and scientists because of the complicated arrangement of the eye. The therapeutic agents needed to deliver the drugs to specific sites of the eye require the crossing of various ocular barriers, which act as hitches for drug delivery. Conventional preparations present in the market do not achieve the desired therapeutic results due to their lower bioavailability, less retention time, or difficulty in reaching the site of action. In a need to overcome the challenges with these preparations, various modern technologies are being applied to address the same with outstanding results. The purpose of the present review is to focus on several innovative approaches, viz., the development of novel ocular drug delivery systems including liposomes, niosomes, nano-wafers, cubosomes, microneedles, dendrimers, and many others, adopted to combat various ocular diseases. In the present review, various novel formulations and drug delivery approaches have been taken into consideration, as developed, and reported by various scientists and researchers working in the field of ocular drug delivery systems.

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NOVEL APPROACHES IN OCULAR DRUG DELIVERY-A REVOLUTION

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