REVIEW OF SARS-CORONAVIRUS-2 REPERCUSSIONS ON THYROID GLAND IN THE CONTEXT OF HYPERTHYROIDISM
DOI:
https://doi.org/10.22159/ijap.2023v15i5.47937Keywords:
Hyperthyroidism, SARS-corona virus-2, Thyroid gland, Graves disease, Covid-19Abstract
The thyroid gland may generate, store, and release hormones (such as Triiodothyronine and Thyroxin also called T3 and T4 hormones respectively) into the bloodstream and let them go to the body's cells. Every enzymatic process in the production and secretion of thyroid hormones is controlled by Thyroid stimulating hormone (TSH). All people worldwide are susceptible to thyroid disease, which is often accompanied by hyperthyroidism and hypothyroidism. The thyroid's structural proximity to the upper airways, a main route for coronavirus entry, holds up the idea that the thyroid gland might be a target for Covid-19 or SARS-CoronaVirus-2. When the thyroid gland makes and secretes too much thyroid hormone, it is referred to as hyperthyroidism and if the patients do not take any precautions, hyperthyroidism may lead to cardiac hypertrophy. The Covid-19 epidemic had a substantial influence on our daily lives and has unexpectedly changed the way of medical research. This review aimed to discuss the effects of SARS-CoronaVirus-2 on the Thyroid Gland in the Context of Hyperthyroidism and related causing diseases, highlighting the common causing diseases of hyperthyroidism along with their treatments. We also highlight the impact of SARS-CoronaVirus-2 and its mRNA immunization. So that future studies should focus on the number of important advances and improved drug management in the treatment of Thyroid relating diseases, which may or may not be triggered by the coronavirus and its immunization.
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Yussuf YA, Bhogireddy N, Vulli V, Verma A, Bhaskaran AA. Thyroid stimulating hormones and free thyroxine as an indication of thyroid dysfunction at pathology laboratory of Mnazi Mmoja Hospital, Zanzibar. Asian J Pharm Clin Res. 2014 Jan 1:67-71.
Stathatos N. Anatomy and physiology of the thyroid gland. The thyroid and its diseases: a comprehensive guide for the clinician; 2019. p. 3-12.
Klein I, Danzi S. Thyroid disease and the heart. Curr Probl Cardiol. 2016 Feb 1;41(2):65-92. doi: 10.1016/j.cpcardiol.2015.04.002. PMID 26792255.
Podder G, Adhikari A, De A, Banerjee J, De M. Antioxidant enzymes status and thyroid stimulating hormone level of down syndrome patient in West Bengal, India: a case-control study. Asian J Pharm Clin Res. 2013 Nov 1:1-4.
Giovanella L, Avram AM, Ovcaricek PP, Clerc J. Thyroid functional and molecular imaging. Presse Med. 2022 Jun 1;51(2):104116. doi: 10.1016/j.lpm.2022.104116. PMID 35124101.
Wiersinga WM. Graves’ disease: can it be cured? Endocrinol Metab (Seoul). 2019 Mar 1;34(1):29-38. doi: 10.3803/EnM.2019.34.1.29, PMID 30912336.
Sharma A, Stan MN. Thyrotoxicosis: diagnosis and management. Mayo Clin Proc. 2019 Jun 1;94(6):1048-64. doi: 10.1016/j.mayocp.2018.10.011, PMID 30922695.
Smithson M, Asban A, Miller J, Chen H. Considerations for thyroidectomy as treatment for graves disease. Clin Med Insights Endocrinol Diabetes. 2019 Apr;12:1179551419844523. doi: 10.1177/1179551419844523, PMID 31040734.
Vija Racaru LV, Grunenwald S, Hindie E, Taieb D, Clerc J, Zerdoud S. Management of adenomas and toxic multinodular goiters with iodine 131. Medecine Nucleaire. 2020 Oct 1;44(4):272-6. doi: 10.1016/j.mednuc.2020.09.001.
Scappaticcio L, Pitoia F, Esposito K, Piccardo A, Trimboli P. Impact of COVID-19 on the thyroid gland: an update. Rev Endocr Metab Disord. 2021;22(4):803-15. doi: 10.1007/s11154-020-09615-z. PMID 33241508.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395:497-506. doi: 10.1016/S0140-6736(20)30183-5, PMID 31986264.
Rotondi M, Coperchini F, Ricci G, Denegri M, Croce L, Ngnitejeu ST. Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis. J Endocrinol Invest. 2021 May;44(5):1085-90. doi: 10.1007/s40618-020-01436-w, PMID 33025553.
Taylor PN, Albrecht D, Scholz A, Gutierrez Buey G, Lazarus JH, Dayan CM. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018 May;14(5):301-16. doi: 10.1038/nrendo.2018.18, PMID 29569622.
De Leo S, Braverman LE. Iodine-induced thyroid dysfunction. The thyroid and its diseases: a comprehensive guide for the clinician; 2019. p. 435-52.
Wemeau JL, Klein M, Sadoul JL, Briet C, Velayoudom Cephise FL. Graves’ disease: Introduction, epidemiology, endogenous and environmental pathogenic factors. Ann Endocrinol (Paris). 2018;79(6):599-607. doi: 10.1016/j.ando.2018.09.002. PMID 30342794.
Davies TF, Andersen S, Latif R, Nagayama Y, Barbesino G, Brito M. Graves’ disease. Nat Rev Dis Primers. 2020 Jul 2;6(1):52. doi: 10.1038/s41572-020-0184-y, PMID 32616746.
Weetman AP. Graves’ disease. N Engl J Med. 2000 Oct 26;343(17):1236-48. doi: 10.1056/NEJM200010263431707, PMID 11071676.
Antonelli A, Ferrari SM, Ragusa F, Elia G, Paparo SR, Ruffilli I. Graves’ disease: epidemiology, genetic and environmental risk factors and viruses. Best Pract Res Clin Endocrinol Metab. 2020 Jan 1;34(1):101387. doi: 10.1016/j.beem.2020.101387. PMID 32107168.
Kim BW. Does radioactive iodine therapy for hyperthyroidism cause cancer? J Clin Endocrinol Metab. 2022 Feb;107(2):e448-57. doi: 10.1210/clinem/dgab700, PMID 34555150.
Cirocchi R, Trastulli S, Randolph J, Guarino S, Di Rocco G, Arezzo A. Total or near-total thyroidectomy versus subtotal thyroidectomy for multinodular non-toxic goitre in adults. Cochrane Database Syst Rev. 2015;2015(8):CD010370. doi: 10.1002/14651858.CD010370.pub2. PMID 26252202.
Abdi H, Amouzegar A, Azizi F. Antithyroid drugs. Iranian Journal of Pharmaceutical Research. 2019;18Suppl 1:1.
Staniforth JUL, Erdirimanne S, Eslick GD. Thyroid carcinoma in Graves’ disease: a meta-analysis. Int J Surg. 2016 Mar 1;27:118-25. doi: 10.1016/j.ijsu.2015.11.027. PMID 26626367.
Walsh JP. Managing thyroid disease in general practice. Med J Aust. 2016 Aug;205(4):179-84. doi: 10.5694/mja16.00545, PMID 27510349.
Stasiak M, Lewiński A. New aspects in the pathogenesis and management of subacute thyroiditis. Rev Endocr Metab Disord. 2021 Dec;22(4):1027-39. doi: 10.1007/s11154-021-09648-y, PMID 33950404.
Richardson PG, Barlogie B, Berenson J, Singhal S, Jagannath S, Irwin D. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med. 2003 Jun 26;348(26):2609-17. doi: 10.1056/NEJMoa030288, PMID 12826635.
Cukier P, Santini FC, Scaranti M, Hoff AO. Endocrine side effects of cancer immunotherapy. Endocr Relat Cancer. 2017 Dec 1;24(12):T331-47. doi: 10.1530/ERC-17-0358, PMID 29025857.
Barroso Sousa R, Barry WT, Garrido Castro AC, Hodi FS, Min L, Krop IE. Incidence of endocrine dysfunction following the use of different immune checkpoint inhibitor regimens: a systematic review and meta-analysis. JAMA Oncol. 2018 Feb 1;4(2):173-82. doi: 10.1001/jamaoncol.2017.3064, PMID 28973656.
Joshi M, Bisht S, Singh MF. A review: mechanistic insights into the effect of thyroid disorders on estrogen level and bone mineral density. Int J Pharm Pharm Sci. 2019;11(10):9-17. doi: 10.22159/ijpps.2019v11i10.34447.
Biondi B, Cooper DS. Subclinical hyperthyroidism. N Engl J Med. 2018 Jun 21;378(25):2411-9. doi: 10.1056/NEJMcp1709318, PMID 29924956.
Donangelo I, Suh SY. Subclinical hyperthyroidism: when to consider treatment. Am Fam Physician. 2017 Jun 1;95(11):710-6. PMID 28671443.
Bervini S, Trelle S, Kopp P, Stettler C, Trepp R. Prevalence of iodine-induced hyperthyroidism after administration of iodinated contrast during radiographic procedures: a systematic review and meta-analysis of the literature. Thyroid. 2021 Jul 1;31(7):1020-9. doi: 10.1089/thy.2020.0459, PMID 33327840.
Lee SY, Rhee CM, Leung AM, Braverman LE, Brent GA, Pearce EN. A review: radiographic iodinated contrast media-induced thyroid dysfunction. J Clin Endocrinol Metab. 2015 Feb 1;100(2):376-83. doi: 10.1210/jc.2014-3292, PMID 25375985.
Korevaar TIM, Medici M, Visser TJ, Peeters RP. Thyroid disease in pregnancy: new insights in diagnosis and clinical management. Nat Rev Endocrinol. 2017 Oct;13(10):610-22. doi: 10.1038/nrendo.2017.93, PMID 28776582.
Moleti M, Di Mauro M, Sturniolo G, Russo M, Vermiglio F. Hyperthyroidism in the pregnant woman: maternal and fetal aspects. J Clin Transl Endocrinol. 2019 Jun 1;16:100190. doi: 10.1016/j.jcte.2019.100190. PMID 31049292.
Illouz F, Luton D, Polak M, Besançon A, Bournaud C. Graves’ disease and pregnancy. Ann Endocrinol (Paris). 2018;79(6):636-46. doi: 10.1016/j.ando.2018.08.004. PMID 30224035.
Kobaly K, Mandel SJ. Hyperthyroidism and pregnancy. Endocrinol Metab Clin North Am. 2019 Sep;48(3):533-45. doi: 10.1016/j.ecl.2019.05.002. PMID 31345521.
Akamizu T. Thyroid storm: a Japanese perspective. Thyroid. 2018 Jan 1;28(1):32-40. doi: 10.1089/thy.2017.0243, PMID 28899229.
Chiha M, Samarasinghe S, Kabaker AS. Thyroid storm: an updated review. J Intensive Care Med. 2015 Mar;30(3):131-40. doi: 10.1177/0885066613498053, PMID 23920160.
Burch HB. Drug effects on the thyroid. N Engl J Med. 2019 Aug 22;381(8):749-61. doi: 10.1056/NEJMra1901214, PMID 31433922.
Koren G, Ornoy A, Berkovitch M. Hyperemesis gravidarum-Is it a cause of abnormal fetal brain development? Reprod Toxicol. 2018 Aug 1;79:84-8. doi: 10.1016/j.reprotox.2018.06.008. PMID 29913206.
Amino N, Arata N. Thyroid dysfunction following pregnancy and implications for breastfeeding. Best Pract Res Clin Endocrinol Metab. 2020 Jul 1;34(4):101438. doi: 10.1016/j.beem.2020.101438. PMID 32651061.
Caron P. Thyroiditis and SARS-CoV-2 pandemic: a review. Endocrine. 2021 May;72(2):326-31. doi: 10.1007/s12020-021-02689-y, PMID 33774779.
Yap PS, Ali O, Truran P, Aspinall S. Thyrotoxicosis and thyroiditis. Surgery (Oxford). 2020 Dec 1;38(12):794-800. doi: 10.1016/j.mpsur.2020.10.002.
Cao J, Zhang M, Zhang L, Lou J, Zhou F, Fang M. Non-coding RNA in thyroid cancer–functions and mechanisms. Cancer Lett. 2021 Jan 1;496:117-26. doi: 10.1016/j.canlet.2020.08.021. PMID 32949678.
Siegel MR, Wolsky RJ, Alvarez EA, Mengesha BM. Struma ovarii with atypical features and synchronous primary thyroid cancer: a case report and review of the literature. Arch Gynecol Obstet. 2019 Dec;300(6):1693-707. doi: 10.1007/s00404-019-05329-z, PMID 31679038.
Rejlekova K, Cursano MC, De Giorgi U, Mego M. Severe complications in testicular germ cell tumors: the choriocarcinoma syndrome. Front Endocrinol. 2019 Apr 12;10:218. doi: 10.3389/fendo.2019.00218, PMID 31031704.
Beck Peccoz P, Giavoli C, Lania A. A 2019 update on TSH-secreting pituitary adenomas. J Endocrinol Invest. 2019 Dec;42(12):1401-6. doi: 10.1007/s40618-019-01066-x, PMID 31175617.
Boelaert K, Visser WE, Taylor PN, Moran C, Leger J, Persani L. Endocrinology in the time of Covid-19: management of hyperthyroidism and hypothyroidism. Eur J Endocrinol. 2020 Jul;183(1):G33-9. doi: 10.1530/EJE-20-0445, PMID 32438340.
Hossain MF, Hasana S, Mamun AA, Uddin MS, Wahed MII, Sarker S. Covid-19 Outbreak: pathogenesis, current therapies, and potentials for future management. Front Pharmacol. 2020 Oct 16;11:563478. doi: 10.3389/fphar.2020.563478, PMID 33178016.
Murugan AK, Alzahrani AS. SARS-CoV-2 plays a pivotal role in inducing hyperthyroidism of Graves’ disease. Endocrine. 2021 Aug;73(2):243-54. doi: 10.1007/s12020-021-02770-6, PMID 34106438.
Marazuela M, Giustina A, Puig Domingo M. Endocrine and metabolic aspects of the COVID-19 pandemic. Rev Endocr Metab Disord. 2020 Dec;21(4):495-507. doi: 10.1007/s11154-020-09569-2, PMID 32643004.
Urhan E, Karaca Z, Kara CS, Yuce ZT, Unluhizarci K. The potential impact of COVID-19 on thyroid gland volumes among Covid-19 survivors. Endocrine. 2022 Jun;76(3):635-41. doi: 10.1007/s12020-022-03019-6, PMID 35239124.
Duntas LH, Jonklaas J. Covid-19 and thyroid diseases: a bidirectional impact. J Endocr Soc. 2021 Aug;5(8):bvab076. doi: 10.1210/jendso/bvab076, PMID 34189381.
Trimboli P, Camponovo C, Scappaticcio L, Bellastella G, Piccardo A, Rotondi M. Thyroid sequelae of Covid-19: a systematic review of reviews. Rev Endocr Metab Disord. 2021 Jun;22(2):485-91. doi: 10.1007/s11154-021-09653-1, PMID 33843008.
Yamakawa H, Kato TS, Noh JY, Yuasa S, Kawamura A, Fukuda K. Thyroid hormone plays an important role in cardiac function: from bench to bedside. Front Physiol. 2021 Oct 18;12:606931. doi: 10.3389/fphys.2021.606931, PMID 34733168.
Barreto Chaves ML, Senger N, Fevereiro MR, Parletta AC, Takano AP. Impact of hyperthyroidism on cardiac hypertrophy. Endocr Connect. 2020 Mar;9(3):R59-69. doi: 10.1530/EC-19-0543, PMID 32101527.
Siolos A, Gartzonika K, Tigas S. Thyroiditis following vaccination against COVID-19: report of two cases and review of the literature. Metabol Open. 2021 Dec 1;12:100136. doi: 10.1016/j.metop.2021.100136. PMID 34693241.
Lee KA, Kim YJ, Jin HY. Thyrotoxicosis after covid-19 vaccination: seven case reports and a literature review. Endocrine. 2021 Dec;74(3):470-2. doi: 10.1007/s12020-021-02898-5, PMID 34637073.
Caron P. Thyroid disorders and SARS-CoV-2 infection: from pathophysiological mechanism to patient management. Ann Endocrinol (Paris). 2020;81(5):507-10. doi: 10.1016/j.ando.2020.09.001. PMID 32950466.
Bostan H, Ucan B, Kizilgul M, Calapkulu M, Hepsen S, Gul U. Relapsed and newly diagnosed Graves’ disease due to immunization against Covid-19: A case series and review of the literature. J Autoimmun. 2022 Apr 1;128:102809. doi: 10.1016/j.jaut.2022.102809. PMID 35220164.
Murugan AK, Alzahrani AS. SARS-CoV-2: emerging role in the pathogenesis of various thyroid diseases. J Inflamm Res. 2021;14:6191-221. doi: 10.2147/JIR.S332705. PMID 34853527.
Vojdani A, Vojdani E, Kharrazian D. Reaction of human monoclonal antibodies to SARS-CoV-2 proteins with tissue antigens: implications for autoimmune diseases. Front Immunol. 2020;11:617089. doi: 10.3389/fimmu.2020.617089, PMID 33584709.
Kanduc D, Shoenfeld Y. Molecular mimicry between SARS-CoV-2 spike glycoprotein and mammalian proteomes: implications for the vaccine. Immunol Res. 2020 Oct;68(5):310-3. doi: 10.1007/s12026-020-09152-6, PMID 32946016.
Patrizio A, Ferrari SM, Elia G, Ragusa F, Paparo SR, Mazzi V. Graves’ disease following SARS-CoV-2 vaccination: a systematic review. Vaccines. 2022 Sep 1;10(9):1445. doi: 10.3390/vaccines10091445, PMID 36146523.
Lui DTW, Lee KK, Lee CH, Lee ACH, Hung IFN, Tan KCB. Development of Graves’ disease after SARS-CoV-2 mRNA vaccination: a case report and literature review. Front Public Health. 2021 Nov 23;9:778964. doi: 10.3389/fpubh.2021.778964, PMID 34888290.
Mejia Gonzalez MA, Carbone J. How suitable is intravenous tocilizumab for the treatment of graves’ ophthalmopathy? Expert Rev Clin Immunol. 2021 Nov 2;17(11):1151-3. doi: 10.1080/1744666X.2021.1997591, PMID 34704876.
Abeillon-du Payrat J, Grunenwald S, Gall E, Ladsous M, Raingeard I, Caron P. Graves’ orbitopathy post-SARS-CoV-2 vaccines: report on six patients. J Endocrinol Invest. 2023 Mar;46(3):617-27. doi: 10.1007/s40618-022-01955-8, PMID 36378488.
Aemaz Ur Rehman M, Farooq H, Ali MM, Ebaad Ur Rehman M, Dar QA, Hussain A. The association of subacute thyroiditis with Covid-19: a systematic review. SN Compr Clin Med. 2021 Jul;3(7):1515-27. doi: 10.1007/s42399-021-00912-5, PMID 33942028.
Mattar SAM, Koh SJQ, Rama Chandran SR, Cherng BPZ. Subacute thyroiditis associated with Covid-19. BMJ Case Rep. 2020 Aug 1;13(8):e237336. doi: 10.1136/bcr-2020-237336, PMID 32843467.
Khatri A, Charlap E, Kim A. Subacute thyroiditis from Covid-19 infection: a case report and review of literature. Eur Thyroid J. 2021 Feb 1;9(6):324-8. doi: 10.1159/000511872, PMID 33708634.
Campos Barrera E, Alvarez Cisneros T, Davalos Fuentes M. Subacute thyroiditis associated with Covid-19. Case Rep Endocrinol. 2020;2020:8891539. doi: 10.1155/2020/8891539, PMID 33005461.
Dworakowska D, Morley S, Mulholland N, Grossman AB. Covid‐19‐related thyroiditis: a novel disease entity? Clin Endocrinol (Oxf). 2021 Sep;95(3):369-77. doi: 10.1111/cen.14453, PMID 33650180.
Christensen J, O’Callaghan K, Sinclair H, Hawke K, Love A, Hajkowicz K. Risk factors, treatment and outcomes of subacute thyroiditis secondary to Covid‐19: a systematic review. Intern Med J. 2022 Apr;52(4):522-9. doi: 10.1111/imj.15432, PMID 34139048.
MacDonald N, Mohsni E, Al-Mazrou Y, Kim Andrus J, Arora N, Elden S. Global vaccine action plan lessons learned I: recommendations for the next decade. Vaccine. 2020 Jul 14;38(33):5364-71. doi: 10.1016/j.vaccine.2020.05.003, PMID 32563607.
Olivieri B, Betterle C, Zanoni G. Vaccinations and autoimmune diseases. Vaccines (Basel). 2021 Jul 22;9(8):34451940. doi: 10.3390/vaccines9080815, PMID 34451940, PMCID PMC8402446.
Vojdani A, Kharrazian D. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Clin Immunol. 2020 Aug;217:108480. doi: 10.1016/j.clim.2020.108480. PMID 32461193.
Jafarzadeh A, Nemati M, Jafarzadeh S, Nozari P, Mortazavi SMJ. Thyroid dysfunction following vaccination with Covid-19 vaccines: a basic review of the preliminary evidence. J Endocrinol Invest. 2022 Oct;45(10):1835-63. doi: 10.1007/s40618-022-01786-7, PMID 35347651.
Jiang H, Tian Y, Yan W, Kong Y, Wang H, Wang A. The prevalence of thyroid nodules and an analysis of related lifestyle factors in Beijing communities. Int J Environ Res Public Health. 2016 Apr;13(4):442. doi: 10.3390/ijerph13040442, PMID 27110805.
Uppal A, White MG, Nagar S, Aschebrook Kilfoy B, Chang PJ, Angelos P. Benign and malignant thyroid incidentalomas are rare in routine clinical practice: a review of 97,908 imaging studies. Cancer Epidemiol Biomarkers Prev. 2015;24(9):1327-31. doi: 10.1158/1055-9965.EPI-15-0292. PMID 26160694.
Giannoula E, Iakovou I, Giovanella L, Vrachimis A. Updated clinical management guidance during the Covid-19 pandemic: thyroid nodules and cancer. Eur J Endocrinol. 2022 Apr;186(4):G1-7. doi: 10.1530/EJE-21-0716, PMID 35073277.
Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z. Patients with cancer appear more vulnerable to SARS-CoV-2: A multicenter study during the Covid-19 outbreak patients. Cancer Discov. 2020 Jun 1;10(6):783-91. doi: 10.1158/2159-8290.CD-20-0422. PMID 32345594.
Raghavan D, Tan AR, Story ES, Burgess EF, Musselwhite L, Kim ES. Management changes for patients with endocrine-related cancers in the Covid-19 pandemic. Endocr Relat Cancer. 2020 Sep 1;27(9):R357-74. doi: 10.1530/ERC-20-0229, PMID 32744242.
Tsang VHM, Gild M, Glover A, Clifton Bligh R, Robinson BG. Thyroid cancer in the age of Covid-19. Endocr Relat Cancer. 2020 Nov 1;27(11):R407-16. doi: 10.1530/ERC-20-0279, PMID 32810844.
Prete A, Falcone M, Bottici V, Giani C, Tiseo G, Agate L. Thyroid cancer and Covid-19: experience at one single thyroid disease referral center. Endocrine. 2021 May;72(2):332-9. doi: 10.1007/s12020-021-02650-z, PMID 33638758.
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