SECOND DEGREE BURN WOUND HEALING ACTIVITY TEST OF ETHANOL EXTRACT MAHOGANY BARK (SWIETENIA MAHAGONI (L.) JACQ.)

VITRI AGUSTIARINI; FITRYA; ANNISA AMRIANI; ROHMA SYAKTIFIANI ZERLI

doi:10.22159/ijap.2022.v14s3.07

Authors

VITRI AGUSTIARINI Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Sriwijaya University South Sumatera, 30862, Indonesia
FITRYA Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Sriwijaya University South Sumatera, 30862, Indonesia
ANNISA AMRIANI Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Sriwijaya University South Sumatera, 30862, Indonesia
ROHMA SYAKTIFIANI ZERLI Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Sriwijaya University South Sumatera, 30862, Indonesia

DOI:

https://doi.org/10.22159/ijap.2022.v14s3.07

Keywords:

Ethanol extract, Flavonoid, Mahogany bark, Second-degree burns

Abstract

Objective: This research aims to determine the characteristics and activity of an ethanolic extract of mahogany bark on the healing rate of second-degree burns.

Methods: The animal test consisted of 25 white male rats of the Sprague Dawley strain divided into five groups. The positive group was treated by Lanakeloid-E^®cream, negative group, and treatment groups with varying dosages (100, 200, and 400 mg/Kg Bodyweight). The parameters observed included the time formed, the scab’s shedding time, and the percentage of wound healing. Burn area data were analyzed using the one-way ANOVA test to see if there were differences in the percentage of burns healing between groups.

Results: The results showed that ethanol extract of mahogany bark (Swietenia mahagoni (L.) Jacq.) at a dose of 400 mg/Kg Bodyweightwas the best dose for accelerating burn healing with a recovery rate of 85,706% during 14 d. Statistical test results on the percentage of burn injury between negative and positive controls and the test groups had significantly different results (p<0,05).

Conclusion: This study concludes that presenting the ethanol extract of mahogany bark (Swietenia mahagoni (L.) Jacq) at a dose of 400 mg/Kg Bodyweight shows the best second-degree burns healing.

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